Guesthouse vacation rentals in Frederick County

Find and book unique guesthouse rentals on Airbnb

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Popular amenities for Frederick County guesthouse rentals

Family-friendly guest house rentals

Guest favorite
Guesthouse in Frederick
4.88 out of 5 average rating, 33 reviews

The Wander Inn

BrandonRating, 5 stars3 weeks ago
We stayed here for 5 months and it was awesome! Rani is such a wonderful host, always willing to help us out. The location was great and close to a lot of attractions. Thank you again for hosting us.
Top guest favorite
Guesthouse in Smithsburg
4.97 out of 5 average rating, 734 reviews

Jewel Vinsota Artist's Guesthouse

YiRating, 5 stars6 days ago
My partner, pup, and I had a lovely and cozy stay!! Lots of thoughtful touches, cool artwork, and supplies. We enjoyed using the fire pit right by the creek, our dog was obsessed with the sun room, and we loved exploring the sculpture garden!
Guest favorite
Guesthouse in Frederick
4.98 out of 5 average rating, 178 reviews

Romantic Getaway - Heated Spa Open Year Round

KifleRating, 5 stars1 day ago
An absolute gem of a peaceful and scenic retreat. The guest house was impeccably clean, wonderfully decorated/kept, and the kitchen was well stocked. The pool and jacuzzi were great additions that we used daily. Deborah was a kind, thoughtful, and immensely communicative host. The property itself is within a 15 minute drive to downtown and restaurants. This was a memorable, relaxing stay for us both and we will definitely be returning.
Guest favorite
Guesthouse in Frederick
4.97 out of 5 average rating, 335 reviews

The Shady Bear Cabin

SteveRating, 5 stars1 month ago
Gerry’s place is just what I needed to disconnect. Close to some good hiking and outdoor activities. The place itself has everything you need for a short peaceful stay. Gerry himself was very welcoming and hospitable. I loved this place. I will definitely favorite to go back sometime.
Guest favorite
Guesthouse in Middletown
4.95 out of 5 average rating, 283 reviews

Indulge, Fresh Flowers, Frederick County Haven

SamuelRating, 5 stars1 day ago
This excellent little guest house was great for me and my friends. When we were making a trip up to Connecticut as a halfway stop. Everything was clean and simple and the host was excellent and getting us checked in easy because we had been on a long road trip. Couldn't have asked for an easier place to stay.

Guest house rentals with a washer and dryer

Top guest favorite
Guesthouse in Keymar
4.98 out of 5 average rating, 62 reviews

Historic country guesthouse, newly renovated.

NicholasRating, 5 stars2 months ago
I had a amazing stay at this Airbnb. The host was incredibly friendly and went above and beyond to make my visit special. Upon arrival, I was greeted with freshly baked cookies and a bottle of wine. The space was spotless and extremely comfortable, with everything I needed for a relaxing stay. The location was also perfect, with plenty of activities and attractions nearby to explore. I highly recommend this Airbnb to anyone looking for a welcoming, clean, and cozy place to stay. I’ll definitely be returning on my next visit to the area!
Guest favorite
Guesthouse in Mount Airy
4.97 out of 5 average rating, 118 reviews

Treasured Hideaway on the Hill

JessicaRating, 5 stars6 days ago
I had a lovely stay. I had anything I could need and the place was very cozy. Sooooo much storage in the master bedroom. Would be great for a longer stay.
Guest favorite
Guesthouse in Lovettsville
4.94 out of 5 average rating, 18 reviews

The Tuberose Suite

NateRating, 5 stars3 months ago
Honestly, this was exactly what my wife and I needed. A nice quiet getaway without the kids. Everything was amazing and our host went above and beyond. He even was kind enough to bring us breakfast when I commented how amazing his breakfast smelled through the wall. Unfortunately didn’t make it out to one of Anwar’s two restaurants as we hoped. Highly recommend!
Top guest favorite
Guesthouse in Keymar
5 out of 5 average rating, 8 reviews

The Quilted Cozy Guesthouse

MarkRating, 5 stars6 days ago
Great location. We came here for a weddings and also dis day trips to Gettysburg, Harrisburg, Frederick, 2 State Parks and Hershey for the botanical gardens and chocolate world. Perfect to home base from. Thank you for allowing our pup. There is a full kitchen but we always ate out- sooooo many choices. Will def return.
Guest favorite
Guesthouse in Frederick
4.88 out of 5 average rating, 33 reviews

The Wander Inn

BrandonRating, 5 stars3 weeks ago
We stayed here for 5 months and it was awesome! Rani is such a wonderful host, always willing to help us out. The location was great and close to a lot of attractions. Thank you again for hosting us.
Top guest favorite
Guesthouse in Lovettsville
4.95 out of 5 average rating, 221 reviews

Cottage Escape in Virginia Wine Country

HelenRating, 5 stars2 months ago
This Airbnb was very welcoming and had beautiful surroundings. My dog loved running around! Everything was super clean and they had binders full of activities and recommendations for things to do in the area. I would stay here again 😊
Top guest favorite
Guesthouse in Smithsburg
4.97 out of 5 average rating, 734 reviews

Jewel Vinsota Artist's Guesthouse

YiRating, 5 stars6 days ago
My partner, pup, and I had a lovely and cozy stay!! Lots of thoughtful touches, cool artwork, and supplies. We enjoyed using the fire pit right by the creek, our dog was obsessed with the sun room, and we loved exploring the sculpture garden!
Guest favorite
Guesthouse in Frederick
4.98 out of 5 average rating, 178 reviews

Romantic Getaway - Heated Spa Open Year Round

KifleRating, 5 stars1 day ago
An absolute gem of a peaceful and scenic retreat. The guest house was impeccably clean, wonderfully decorated/kept, and the kitchen was well stocked. The pool and jacuzzi were great additions that we used daily. Deborah was a kind, thoughtful, and immensely communicative host. The property itself is within a 15 minute drive to downtown and restaurants. This was a memorable, relaxing stay for us both and we will definitely be returning.

Destinations to explore