
Guesthouse vacation rentals in Frederick County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Frederick County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
0 of 0 items showing
1 of 3 pages
0 of 0 items showing
1 of 12 pages
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Frederick County guesthouse rentals
Family-friendly guest house rentals
Guest favorite

Guesthouse in Frederick
4.88 out of 5 average rating, 33 reviewsThe Wander Inn
BrandonRating, 5 stars3 weeks ago
We stayed here for 5 months and it was awesome! Rani is such a wonderful host, always willing to help us out. The location was great and close to a lot of attractions. Thank you again for hosting us.
Top guest favorite

Guesthouse in Smithsburg
4.97 out of 5 average rating, 734 reviewsJewel Vinsota Artist's Guesthouse
YiRating, 5 stars6 days ago
My partner, pup, and I had a lovely and cozy stay!! Lots of thoughtful touches, cool artwork, and supplies. We enjoyed using the fire pit right by the creek, our dog was obsessed with the sun room, and we loved exploring the sculpture garden!
Guest favorite

Guesthouse in Frederick
4.98 out of 5 average rating, 178 reviewsRomantic Getaway - Heated Spa Open Year Round
KifleRating, 5 stars1 day ago
An absolute gem of a peaceful and scenic retreat. The guest house was impeccably clean, wonderfully decorated/kept, and the kitchen was well stocked. The pool and jacuzzi were great additions that we used daily. Deborah was a kind, thoughtful, and immensely communicative host. The property itself is within a 15 minute drive to downtown and restaurants. This was a memorable, relaxing stay for us both and we will definitely be returning.
Guest favorite

Guesthouse in Frederick
4.97 out of 5 average rating, 335 reviewsThe Shady Bear Cabin
SteveRating, 5 stars1 month ago
Gerry’s place is just what I needed to disconnect. Close to some good hiking and outdoor activities. The place itself has everything you need for a short peaceful stay. Gerry himself was very welcoming and hospitable. I loved this place. I will definitely favorite to go back sometime.
Guest favorite

Guesthouse in Middletown
4.95 out of 5 average rating, 283 reviewsIndulge, Fresh Flowers, Frederick County Haven
SamuelRating, 5 stars1 day ago
This excellent little guest house was great for me and my friends. When we were making a trip up to Connecticut as a halfway stop. Everything was clean and simple and the host was excellent and getting us checked in easy because we had been on a long road trip. Couldn't have asked for an easier place to stay.
Guest house rentals with a patio
Guest favorite

Guesthouse in Mount Airy
4.97 out of 5 average rating, 118 reviewsTreasured Hideaway on the Hill
JessicaRating, 5 stars6 days ago
I had a lovely stay. I had anything I could need and the place was very cozy. Sooooo much storage in the master bedroom. Would be great for a longer stay.
Top guest favorite

Guesthouse in Keymar
5 out of 5 average rating, 8 reviewsThe Quilted Cozy Guesthouse
MarkRating, 5 stars6 days ago
Great location. We came here for a weddings and also dis day trips to Gettysburg, Harrisburg, Frederick, 2 State Parks and Hershey for the botanical gardens and chocolate world. Perfect to home base from. Thank you for allowing our pup. There is a full kitchen but we always ate out- sooooo many choices. Will def return.
Guest favorite

Guesthouse in Lovettsville
4.92 out of 5 average rating, 181 reviewsThe Patent House
SarahRating, 5 stars3 weeks ago
Amazing little place - so peaceful - bed was comfy and kitchen was well stocked with what I needed for simple meals. Beautiful backyard with covered porch was perfect to watch a thunderstorm that rolled in. Ask about fresh eggs - they were such a treat! Would absolutely stay again! Hard to leave - great hosts!
Guest house rentals with a washer and dryer
Top guest favorite

Guesthouse in Keymar
4.98 out of 5 average rating, 62 reviewsHistoric country guesthouse, newly renovated.
NicholasRating, 5 stars2 months ago
I had a amazing stay at this Airbnb. The host was incredibly friendly and went above and beyond to make my visit special. Upon arrival, I was greeted with freshly baked cookies and a bottle of wine. The space was spotless and extremely comfortable, with everything I needed for a relaxing stay. The location was also perfect, with plenty of activities and attractions nearby to explore. I highly recommend this Airbnb to anyone looking for a welcoming, clean, and cozy place to stay. I’ll definitely be returning on my next visit to the area!
Guest favorite

Guesthouse in Mount Airy
4.97 out of 5 average rating, 118 reviewsTreasured Hideaway on the Hill
JessicaRating, 5 stars6 days ago
I had a lovely stay. I had anything I could need and the place was very cozy. Sooooo much storage in the master bedroom. Would be great for a longer stay.
Guest favorite

Guesthouse in Lovettsville
4.94 out of 5 average rating, 18 reviewsThe Tuberose Suite
NateRating, 5 stars3 months ago
Honestly, this was exactly what my wife and I needed. A nice quiet getaway without the kids. Everything was amazing and our host went above and beyond. He even was kind enough to bring us breakfast when I commented how amazing his breakfast smelled through the wall. Unfortunately didn’t make it out to one of Anwar’s two restaurants as we hoped. Highly recommend!
Top guest favorite

Guesthouse in Keymar
5 out of 5 average rating, 8 reviewsThe Quilted Cozy Guesthouse
MarkRating, 5 stars6 days ago
Great location. We came here for a weddings and also dis day trips to Gettysburg, Harrisburg, Frederick, 2 State Parks and Hershey for the botanical gardens and chocolate world. Perfect to home base from. Thank you for allowing our pup. There is a full kitchen but we always ate out- sooooo many choices. Will def return.
Guest favorite

Guesthouse in Frederick
4.88 out of 5 average rating, 33 reviewsThe Wander Inn
BrandonRating, 5 stars3 weeks ago
We stayed here for 5 months and it was awesome! Rani is such a wonderful host, always willing to help us out. The location was great and close to a lot of attractions. Thank you again for hosting us.
Top guest favorite

Guesthouse in Lovettsville
4.95 out of 5 average rating, 221 reviewsCottage Escape in Virginia Wine Country
HelenRating, 5 stars2 months ago
This Airbnb was very welcoming and had beautiful surroundings. My dog loved running around! Everything was super clean and they had binders full of activities and recommendations for things to do in the area. I would stay here again 😊
Top guest favorite

Guesthouse in Smithsburg
4.97 out of 5 average rating, 734 reviewsJewel Vinsota Artist's Guesthouse
YiRating, 5 stars6 days ago
My partner, pup, and I had a lovely and cozy stay!! Lots of thoughtful touches, cool artwork, and supplies. We enjoyed using the fire pit right by the creek, our dog was obsessed with the sun room, and we loved exploring the sculpture garden!
Guest favorite

Guesthouse in Frederick
4.98 out of 5 average rating, 178 reviewsRomantic Getaway - Heated Spa Open Year Round
KifleRating, 5 stars1 day ago
An absolute gem of a peaceful and scenic retreat. The guest house was impeccably clean, wonderfully decorated/kept, and the kitchen was well stocked. The pool and jacuzzi were great additions that we used daily. Deborah was a kind, thoughtful, and immensely communicative host. The property itself is within a 15 minute drive to downtown and restaurants. This was a memorable, relaxing stay for us both and we will definitely be returning.
Destinations to explore
- Rentals with a washer and dryer Frederick County
- Rentals with a hot tub Frederick County
- Farmstay rentals Frederick County
- Rentals with lake access Frederick County
- Apartment rentals Frederick County
- House rentals Frederick County
- Rentals with a patio Frederick County
- Rentals with outdoor seating Frederick County
- Pet-friendly rentals Frederick County
- Rentals with breakfast Frederick County
- Condo rentals Frederick County
- Kid-friendly rentals Frederick County
- Rentals with pools Frederick County
- Rentals with a fire pit Frederick County
- Rentals with a fireplace Frederick County
- Guesthouse rentals Maryland
- Guesthouse rentals United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Nationals Park
- The White House
- Lincoln Park
- Whitetail Resort
- National Mall
- Liberty Mountain Resort
- Hampden
- National Museum of African American History and Culture
- Georgetown University
- Smithsonian American Art Museum
- Caledonia State Park
- Smithsonian National Museum of Natural History
- Arlington National Cemetery
- Cacapon Resort State Park
- Gambrill State Park
- Georgetown Waterfront Park
- Patterson Park
- National Air and Space Museum
- Washington Monument
- Stone Tower Winery
- National Harbor
- Great Falls Park
- Oriole Park at Camden Yards
- District Wharf