Guesthouse vacation rentals in Anderson County

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Popular amenities for Anderson County guesthouse rentals

Family-friendly guest house rentals

Top guest favorite
The exterior of the property is shown, featuring yellow siding complemented by dark shutters on the windows. A single door with glass panels is visible, providing a welcoming entrance. A grassy area is located at the base of the wall, enhancing the outdoor setting.
Guesthouse in Liberty
4.93 out of 5 average rating, 195 reviews

Holly Hideaway! 10 Highway miles to Clemson U!

MartiRating, 5 stars2 days ago
Our stay at Jen's place was under special circumstances and to say that Jen was simply accommodating, would be a gross understatement!! Her sweet, quiet, and private guest home proved to be a true God send. Jen went above and beyond to make us feel at home and we are forever grateful.
Guest favorite
A spacious living area is presented with high ceilings. A neutral-toned sofa and an armchair are complemented by a coffee table at the center. Colorful artwork, including a world map, adorns the walls, contributing to a vibrant yet relaxing atmosphere.
Guesthouse in Pendleton
4.89 out of 5 average rating, 257 reviews

La Bella Farm

AdrienneRating, 5 stars2 weeks ago
We love staying here when we visit our son who is a student at Clemson. Very clean and excellent communication.
Top guest favorite
A spacious private suite features a king bed with soft linens and decorative pillows. The dark accent wall adds depth, while a small kitchenette is visible in the background. Nightstands flank the bed, accompanied by soothing lighting. A plush area rug and bright decor contribute to a welcoming ambiance.
Private room in Pelzer
4.98 out of 5 average rating, 125 reviews

South Oaks Guesthouse

BethRating, 5 stars2 months ago
Diane's place was just what we needed for an overnight stay to watch an early bike race the next morning that took place right near by. The room was clean and the coffee cake was delicious, as described in many other reviews. The room was a bit smaller than expected for the price, but it was beautifully decorated and extremely comfortable. We would definitely stay again!
Top guest favorite
A comfortable living area is presented with a mix of seating options, including a couch and two armchairs. Natural light enters through the windows, which are dressed in soft curtains. A coffee table sits in the center, complemented by tasteful decor on the walls.
Guesthouse in Donalds
4.99 out of 5 average rating, 370 reviews

Home on the farm

TaraRating, 5 stars3 weeks ago
We didn’t get to fully enjoy it, due to other obligations. Our kids loved it and want to come back to stay for week. :) Mrs. Ruth and Mr. Robert were so kind, friendly and helpful. Such a peaceful place to stay. Highly recommend!
Guest favorite
A rustic cabin features a wooden exterior with a star decoration, surrounded by landscaped rocks and plants. A covered porch provides seating and is complemented by an umbrella. The structure is nestled among tall trees, creating a serene environment.
Guesthouse in Townville
4.86 out of 5 average rating, 254 reviews

Lisa’s Lodge

MonicaRating, 5 stars6 days ago
This little cabin was a perfectly sweet place for my husband and I to stay while visiting our son. The location was very convenient to every place we needed or wanted to visit. Although we didn't get the chance to actually visit with the hosts, we were greeted by Lisa and told she was available for anything we may need. I highly recommend this little cabin, and would definately stay there again!!

Guest house rentals with a patio

Top guest favorite
A serene lake scene at sunset is depicted, showcasing vibrant hues of orange and pink reflecting on the calm water's surface. The silhouette of trees can be seen along the shore, enhancing the tranquil atmosphere.
Guesthouse in Seneca
5 out of 5 average rating, 34 reviews

One Particular Cove ... on Lake Hartwell

BrianRating, 5 stars2 weeks ago
Love it here. Second time we’ve stayed with them, and they’re so friendly and accommodating!
Top guest favorite
Guesthouse in Pelzer
4.97 out of 5 average rating, 36 reviews

Birdsong Bungalow-Family and Pet Friendly

RelissaRating, 5 stars1 week ago
Amy’s place was so welcoming and with a home like feel! She made sure every need was met for our family. We will be making this our yearly spot from now on!
Top guest favorite
The exterior of the apartment building is visible, featuring a rustic design with wooden elements and a metal roof. A spacious driveway leads to the double garage doors, surrounded by landscaped greenery and blooming flowers. Trees in the background provide a peaceful environment.
Guesthouse in Hartwell
4.98 out of 5 average rating, 92 reviews

1 bedroom lake front apartment with gorgeous views

JoeyRating, 5 starstoday
David and Romona had a beautiful place, they were very nice, and very friendly. The lake as beautiful and they had a beautiful home. Would come back.
Top guest favorite
A living area features a large red couch accompanied by a matching armchair. A coffee table sits in the center, adorned with decorative items. Natural light enters through a nearby window, and a ceiling fan hangs overhead, adding to the comfort of the space.
Guesthouse in Clemson
5 out of 5 average rating, 42 reviews

Downtown Clemson Guest Suite!

CassieRating, 5 stars1 week ago
We had the perfect weekend stay! Easy walk to campus and plenty of shops and dining options! Space was perfect for the two of us and had everything you could need!
Top guest favorite
A living area features a pair of comfortable leather sofas and a coffee table, with a decorative area rug beneath. In the background, a queen bed with a floral-patterned coverlet is positioned beside a wall adorned with artwork depicting guitars.
Guesthouse in Clemson
5 out of 5 average rating, 21 reviews

Adorable Cottage 2 mi. from Death Valley

OrlaRating, 5 stars5 months ago
We had a wonderful stay at Harold and Bonnie’s place. It was a home away from home while we attended a Clemson football game and visited our niece. Everything was spotless, comfortable and welcoming. It was so nice to meet and chat with Harold and Bonnie and we really appreciated the welcome muffins and available snacks that helped us survive our flight home! Would definitely recommend their place to anyone visiting Clemson and have already told our family to book it next time they visit.
Top guest favorite
Guesthouse in Central
5 out of 5 average rating, 14 reviews

Vacation Home Clemson and Lakes

LoriRating, 5 stars8 months ago
This home was just as described, and a comfortable place while we helped our daughter move into her apartment. Super close to Clemson, but quiet and private at the same time. Enjoyed our stay- will stay again! Thanks for having us!
Top guest favorite
Guesthouse in Seneca
5 out of 5 average rating, 16 reviews

Quin's Lake House, Keowee. Private bottom Floor.

EmmaRating, 5 stars3 weeks ago
This is a beautiful place to stay on the water. Owner is continuing to make updates to make the stay easier particularly in the kitchen area.
Guest favorite
An open kitchen and living area features stainless steel appliances, including a large refrigerator and oven. A spacious granite countertop complements the dark cabinetry, while a mounted television and desk area are visible in the background. Bright natural light enters through multiple windows.
Guesthouse in Greenville
5 out of 5 average rating, 13 reviews

Casita Guest House- Country Feel- Great Location

RichardRating, 5 stars6 months ago
Dans place was very clean and modern. Super spacious in a very quiet location with relaxing woods behind the property. Easy access to Greenville, restaurants and the interstate. Dan was very responsive and accommodating. Great stay!

Guest house rentals with a washer and dryer

Top guest favorite
A wooden front porch features a swing with patterned cushions and a decorative wreath on the door. Soft lighting fixtures are mounted above, and a natural area of grass and trees is visible beyond the porch, providing a peaceful outdoor setting.
Guesthouse in Pelzer
4.95 out of 5 average rating, 66 reviews

Quaint guest cottage in Upstate

ConnieRating, 5 stars3 weeks ago
We had a nice stay here. Everything was as described, the place was clean and well-appointed, and we wished we'd had more time to enjoy the porch swing and the setting. There is a bit of traffic noise from the nearby road, but unless you're a very light sleeper, it shouldn't bother you much. We slept well, and the bed was very comfy! We would definately stay here again.
Superhost
A bright bedroom features a spacious bed covered with a white quilt. Natural light filters through the sliding glass door, providing a view of the outdoors. A ceiling fan adds a cool breeze, while soft textures, including an orange throw, enhance the serene environment.
Guesthouse in Seneca
5 out of 5 average rating, 4 reviews

The Cottage at Keowee Hollow

JoshRating, 5 stars2 weeks ago
Alan and Wanda's cozy, clean, and peaceful cottage and was nothing short of spectacular. The surrounding area was magnificent, and the level of hospitality they showed us was above and beyond. I definitely felt like I got my money's worth at this spot. I would highly recommend booking with them.
A wooden adirondack chair is positioned on the edge of a dock, facing calm lake waters. The surrounding landscape features bare trees reflecting muted colors beneath a blue sky with scattered clouds.
Guesthouse in Townville
5 out of 5 average rating, 9 reviews

Paradise Point on Lake Hartwell

ZachRating, 5 stars9 months ago
Paradise point was wonderful! Easy check-in, kids loved the game room, and the dock made it easy for kayaking & docking our boat. We will be back for sure!
Guest favorite
A modern kitchen is presented, featuring white cabinetry and a wood countertop. A black stove and microwave stand against the wall, with a sink positioned nearby. Natural light filters through the window, highlighting decorative elements on the shelves.
Guesthouse in Clemson
4.94 out of 5 average rating, 17 reviews

Clemson Carriage House - NEW!

KathrynRating, 5 stars1 month ago
We loved this adorable apartment! Everything was so clean and nice and we loved all the Clemson tigers everywhere! Would definitely come back for another stay!
Top guest favorite
An inviting entrance features a wooden porch with decorative flowers and a bench. A staircase leads to the upper-level apartment, while an American flag adds a patriotic touch. Natural light illuminates the space, creating a welcoming ambiance.
Guesthouse in Seneca
5 out of 5 average rating, 15 reviews

Hartwell Hideway

DonnaRating, 5 stars2 days ago
So enjoyed my stay. Angie and her husband are both very accommodating. Their property is easy to access, quiet and peaceful. The space is extremely clean and comfortable. I was only there for one night but the space is set up for a comfortable longer stay. I greatly appreciated real cream for my coffee and light snacks as I didn’t have time to make or grab breakfast when I checked out. The place is definitely set up for making easy meals if you are there for a longer stay. I’d highly recommend this place.
The elevated rear of the house showcases multiple levels with spacious decks. Bright blue Adirondack chairs are arranged on a stone patio, complementing the natural landscape. Surrounding greenery and a gently sloped path lead to the home, enhancing the inviting outdoor space.
Guesthouse in Townville
4.67 out of 5 average rating, 6 reviews

Beautiful Luxury home on Lake Hartwell by Clemson

BradyRating, 5 stars32 months ago
Great place & location for peace and sound. Would highly recommend to stay there again.
Top guest favorite
A newly constructed over-garage apartment is showcased with a stylish white exterior. Large garage doors in a muted grey are positioned symmetrically beneath a peaked roof. A prominent window allows natural light to enter, enhancing the home's overall aesthetic.
Guesthouse in Clemson
5 out of 5 average rating, 19 reviews

Riggs Drive Gameday Getaway

RyanRating, 5 stars1 week ago
Great place with perfect walking access to downtown. Hosts were responsive and had the place clean and ready for us.
Superhost
A newly built home features a modern design with white siding and stone accents. The exterior is complemented by a spacious driveway and landscaped edges. Large windows provide natural light, while the mixed roofing adds visual interest.
Guesthouse in Anderson
4.86 out of 5 average rating, 7 reviews

Cozy 2BR lakeside apt w dock near marina & Clemson

JenniferRating, 5 stars17 months ago
We thoroughly enjoyed our stay in the studio apartment at Hartwell Hideaway. We visited for the last Clemson home game of the season. Hartwell Hideout provided the perfect landing pad for us after a busy and fun day of taligating. The home is an easy 20 minute drive from the heart of campus. We thoroughly enjoyed this peaceful and comfortable space that is well appointed with all the comforts of home in a gorgeous lake setting. Rebecca was very responsive and made sure we had everything we needed for a stress-free weekend away! We will definately be back!

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