
Guesthouse vacation rentals in Alachua County
Find and book unique guesthouse rentals on Airbnb
Top-rated guesthouse rentals in Alachua County
Guests agree: these guesthouse rentals are highly rated for location, cleanliness, and more.
Vacation rentals for every style
Get the amount of space that is right for you
Popular amenities for Alachua County guesthouse rentals
Family-friendly guest house rentals

King room at Pareners Branch Creek Guesthouse
This place was a perfect getaway for us. The pool area is amazing and so relaxing. My family enjoyed the pickleball and basketball. The beds were so comfortable and the room was very clean. Jane greeted us and was very friendly and accommodating. We would love to visit again.

Sunflower Acres Cottage
This is our second time staying here, and we couldn’t be happier! This place has quickly become one of our favorites, and it tops our list whenever we're in the area. It has such a peaceful vibe and is always so clean. Plus, the interior is just lovely! We really enjoy our time here.

Gator Getaway
A great, cozy place to stay. Its the closest place you will find right next to the Easton Archery Center.

Renovated Private Studio - Walking Distance to UF
Came down for my son to attend Florida days. This place is absolutely perfect. The bathroom is amazing. This place has everything you need. Perfect little studio. Exactly as described and even better in person. This will be my go-to place when I visit my son!

Beautiful Cottage 10 Minute Walk from UF & Stadium
This was a fantastic rental. Quiet, private, very clean. Rich was helpful but not intrusive at all. I'm a light sleeper, but the thermostat and window treatments kept the place perfectly cool and dark, and the suite is super quiet. Thr selection of local beers in the fridge and coffee pods were a fantstic touch. Certainly the best airbnb experience I've ever had.

Private bed and bath above detached garage.
Wonderful, cute, very clean, very peaceful. As others have said, it's just a bit hard to locate, but it's well worth it. Be prepared for a bit of an adventure and you'll find a treasure worth seeking. :)
Guest house rentals with a patio

Millhopper Modern near UF&Shands
Kaloni’s place was adorable! There was attention to detail for anything you might need during your stay. The entire place looked like it was professionally decorated and I’m in love with the wallpaper in the bathroom! The location was convenient, the place sparkling clean and quiet! I highly recommend staying there.

Private Detached Pool House With Kitchenette
We enjoyed our stay at Glenn's place. The room was private, clean and comfortable. It was located in a quiet neighborhood. We would recommend Glenn's if your looking for a nice place to stay that covers the basics.

The house of smiles.
Great stay! Angela is very responsive and fixed and issue with the tv/internet. Thanks Angela!

Horning’s Guest House -room for 14
Stayed here for a day trip and this place was so nice!! The owners were so communicative and hospitable, even bringing us eggs, milk, and other condiments, The snow cone machine was so good, and we loved the variety of syrups for coffee! Everyone had a great time and there were more than enough spaces for people to sleep on. Will definitely have to book again😆

Walk to UF! Historic King Bed Loft w/ Private Deck
We were comfortable in the space. Very convenient location to our points of interest. Would definitely book again.

Our Nest Cute House!
Luis is by far the best host I’ve encountered on Airbnb—kind, helpful, and incredibly responsive. The place was clean, cozy, and quiet, all at a great price. What more could you ask for? Highly recommended!!

Private entrance guest suite
Had a wonderful stay!! The space is cozy and very convenient. Really quiet and perfect for me and my pup. Would definitely book another stay in the future.

"Nest" in the Guest House up in the Trees near UF
We loved our stay in this beautifully appointed home. The kitchen was stocked with everything we needed to prepare a meal, and there were even snacks and drinks upon our arrival. Deborah goes above and beyond to make sure her guests feel welcome and well accommodated. We are so glad we found this very special place and will definitely return when visiting Gainesville again.
Guest house rentals with a washer and dryer

Cozy guest room w/double at Pareners Branch Creek
Super sweet host, and room was incredibly cozy and I was able to feel right at home ear the beautiful Alachua scenery

Downtown Studio - 1/2 Mile from UF Campus
Nice small guest house to stay in, right next to UF. Perfect for our needs.

Mother in Law suite/Apartment @ Staycation
Another fantastic quick stay at this Airbnb in downtown High Springs! The location is unbeatable—just a short walk to great restaurants, shops, and coffee spots, and only a quick drive to the beautiful natural springs. The home was clean, comfortable, and had everything I needed for a relaxing stay. Whether you're here for outdoor adventures or just to enjoy the charming town, this is the perfect place to stay. I’ll definitely be back!

Cedar Guesthouse
It was a perfect location for visiting my children at the University of Florida. I had a great stay, I felt at home. The only thing was that there was no soap or shampoo, but fortunately I had brought my own. I would definitely stay there again.

Palm N' Pillow • Guesthouse by UF, HCA-FL & Shands
We had a great short stay at the Palm-n Pillow! Gabriela was a great host! Hope to be back soon

Garden Cottage Sanctuary
By far, the best place I have stayed in Gainesville. The home was lovely and very safe for someone traveling by themselves. Laura was a fantastic host by offering local suggestions and even had a welcome bottle of wine and snacks waiting on me. I will plan my work trips around availability as this is now the only place I want to stay.

Sweetwater Studio, on 5 beautiful acres
Nice clean space for our quick weekend getaway. Bhishma provided clear instructions to help us arrive. We kept in touch letting him know we would be late arriving. He made sure the lights were on and the outside was nicely lit to provide Easy access to get in. Tidy and lovely space to relax, comfy beds made for a great night sleep. We drove through the small towns, enjoyed our time roaming through the quaint antique shops then to Gainesville for a little shopping and supper. Thanks Bhishma for a wonderful place to stay.

2.1 miles to campus 1B/1BA Work desk 50”tv+streams
Mayra was the PERFECT host ! If I could give more than ⭐️⭐️⭐️⭐️⭐️ review I would! This place was the perfect fit if you are needing a peaceful, quiet, relaxing and most importantly private place THIS IS THE ONE ! Everything was exactly as stated and pictured and if I'm being honest the pictures does no justice. I book this place last minute and as soon as I booked Mayra was at my services exquisite customer service
Destinations to explore
- Rentals with a fire pit Alachua County
- Rentals with a kayak Alachua County
- Rentals with lake access Alachua County
- Rentals with breakfast Alachua County
- Fitness-friendly rentals Alachua County
- Tiny house rentals Alachua County
- Kid-friendly rentals Alachua County
- Rentals with a fireplace Alachua County
- Pet-friendly rentals Alachua County
- Rentals with outdoor seating Alachua County
- Farmstay rentals Alachua County
- Apartment rentals Alachua County
- Rentals with a hot tub Alachua County
- Private suite rentals Alachua County
- Waterfront rentals Alachua County
- Rentals with a patio Alachua County
- Condo rentals Alachua County
- House rentals Alachua County
- Townhouse rentals Alachua County
- Rentals with a washer and dryer Alachua County
- Rentals with pools Alachua County
- Rentals with an EV charger Alachua County
- Guesthouse rentals Florida
- Guesthouse rentals United States
- Yurt Rentals United States
- Yurt Rentals United Kingdom
- Castle Rentals United States
- Houseboats United States
- Holiday Caravans United Kingdom
- Private Island Rentals United States
- Farm Houses United States
- Farm Cottages United Kingdom
- Cabin Rentals Australia
- Luxury Cabins United Kingdom
- Luxury Cabins United States
- Holiday Chalets United Kingdom
- Cottage Rentals United States
- Holiday Cottages United Kingdom
- Mansion Rentals United States
- Villa Rentals United Kingdom
- Holiday Bungalows United Kingdom
- Bungalow Rentals United States
- Condo Rentals United States
- Holiday Apartments Australia
- Holiday Houses United States
- Holiday Houses United Kingdom
- Private Holiday Rentals United Kingdom
- Big House Rentals United States
- Big Cottages Australia
- Large Villas United Kingdom
- House Rentals with a Pool United States
- Cabin Rentals with a Pool United States
- Villas with a Pool United Kingdom
- Apartments with a Hot Tub United States
- Holiday Cottages with a Hot Tub United Kingdom
- Beach Cabins United States
- Beach Condos United States
- Beachfront Rentals United States
- Beach Houses United Kingdom
- Beach Villas United Kingdom
- Coastal Cottages United Kingdom
- Pet-Friendly Vacation Rentals United States
- Pet-Friendly Beach Rentals United States
- Pet-Friendly Cabin Rentals United States
- Dog-Friendly Cottages United Kingdom
- Luxury Dog-Friendly Cottages United Kingdom
- Ginnie Springs
- Rainbow Springs State Park
- Manatee Springs State Park
- Gilchrist Blue Springs State Park
- Paynes Prairie Preserve State Park
- Ichetucknee Springs State Park
- Eagle Landing Golf Club
- Florida Museum of Natural History
- Bent Creek Golf Course
- Ravine Gardens State Park
- Depot Park
- Ocala Golf Club
- Ocala National Golf Club
- Citrus Springs Golf & Country Club
- The Preserve Golf Club
- Ironwood Golf Course
- Fanning Springs State Park