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Vacation rentals in Semmes

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Semmes

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Home in Mobile
5 out of 5 average rating, 25 reviews

Walk to Univ. South Alabama/Southern Retreat

Welcome to a Gulf Coast getaway in Mobile, Alabama, perfectly located within walking distance of University of South Alabama. Whether visiting for game day, campus tours, graduation or a day trip to our beautiful beaches, this welcoming home offers comfort, convenience and a taste of Southern hospitality. Enjoy cozy living areas, designated work/study areas, a fully equipped kitchen and comfy, cozy bedrooms for a restful stay. We'd love to host you and make your stay comfortable and memorable.

Top guest favorite
A charming front porch features two black rocking chairs positioned beside a small potted plant. The porch is detailed with white brick columns and a wooden ceiling. Lush green trees surround the area, enhancing the inviting entrance to the home.
Home in Mobile
4.97 out of 5 average rating, 134 reviews

1930s Bungalow | 3 BR, Midtown

Enjoy a stay in our stylishly updated 1930s home. This centrally located vintage oasis will take you back in time if you explore our 95 year old hardwood floors. Centrally-located to all of Midtown & Downtown Mobile, you’re a 15-20 min walk or 5-10 minute drive away to all the hotspots. Enjoy a morning stroll under a canopy of live oak trees to soul caffeine, brunch at The Cheese Cottage, happy hour on the roof at Greers, & dine at Hummingbird Way Oyster Bar, all within 3 miles of our house.

Guest favorite
A spacious outdoor pavilion is illuminated by warm string lights along the wooden beams. Several benches are arranged around the perimeter, creating an inviting gathering space. The entrance features a white door framed by a brick wall, offering easy access to the area.
Home in Mobile County
5 out of 5 average rating, 27 reviews

Guest Favorite/Private Cabana-15min to Downtown

Relax and unwind at DubTwins Cottage, a peaceful 3BR, 2BA retreat near Downtown Mobile. Enjoy a private, screened, and comfortable outdoor cabana with a nice grill area, perfect for relaxing or dining outside. Inside features a full kitchen, dining room, family room, and full laundry. Guests love the quiet neighborhood, spotless clean home, and cozy comfort. Ideal for families, business travelers, and anyone in town for sporting events, Mardi Gras, or a Gulf Coast getaway with nearby beaches.

Top guest favorite
The entrance to a unique stone castle is framed by lush greenery and colorful flower beds. A tall, round tower features a window, and the distinctive roof is crafted from slate. Sunlight filters through the surrounding trees, enhancing the natural setting.
Castle in Fairhope
4.99 out of 5 average rating, 645 reviews

Storybook Castle BnB

Sheldon Castle is a registered Baldwin County Historic home. It is a unique, artistic structure right in Fairhope but secluded on a side street. The Eastern Shore Art Center is down the drive and across the street. From there you are in wonderful downtown Fairhope. The studio suite is a completely private part of Sheldon Castle with the Sheldon descendants in the rest of the home. Mosher Castle with a moat and dragon is next door. Our guests are invited to walk the grounds of both castles.

Top guest favorite
Guesthouse in Semmes
4.96 out of 5 average rating, 24 reviews

Retro Tranquility

Take it easy at this unique and tranquil getaway. This MCM-inspired apartment is the perfect stay for those not wanting to stay in a hotel or your everyday short-term rental. Enjoy a retro-inspired aesthetic in the peace and quiet of a country setting. Enjoy your morning coffee on the second story balcony as the sun rises, overlooking a creek fed pond that is home to ducks, geese and other wildlife. Retro is the theme, but modern conveniences will help make your stay complete.

Guest favorite
A spacious living area is highlighted by a large L-shaped couch positioned around a stone fireplace. Natural light filters through sheer curtains, illuminating decorative plants that add a touch of greenery. A mounted television offers entertainment options in this inviting space.
Home in Semmes
4.89 out of 5 average rating, 79 reviews

Oak Hill: 2 Acres w/ 4 Bedrooms

Enjoy the "Country" on 2 acres and inside you'll find a freshly remodeled home. The four bedrooms make this a great place for families or friends traveling together. Relax by the pool or smokeless firepit, explore the land, play basketball or board games. Within 5 Minutes: Walmart Supercenter, grocery stores and restaurants. Within 10-15 minutes: Big Creek Lake w/ boat launch & fishing, golf, disc golf, bowling, laser tag, splash pad (seasonal), several parks and shopping.

Guest favorite
A spacious living area features brown leather sofas set on warm wooden flooring. A dining space is visible in the background, with a dark wood table and chairs. Neutral walls are adorned with artwork, and a fireplace serves as a focal point, complemented by a flat-screen TV.
Home in Mobile
4.95 out of 5 average rating, 114 reviews

Convenience Cottage/Close to ALL

Your family will be close to everything when you stay at this centrally-located place. Minutes from South Alabama (USA), Springhill College, Mobile Tennis Center, parks, golf, Mobile Art Museum, Fair Grounds, and much more. The home sits on a large corner lot easy to find. Large privacy fenced back yard for you and your four legged family members to enjoy. Also has a large covered back deck to enjoy along with a gas grill. Walking distance to the park and Japanese’s garden.

Guest favorite
A spacious living area features light-colored leather seating arranged around a glass coffee table. A ceiling fan and decorative lighting enhance the space. Large windows allow natural light, and a fireplace adds a cozy element, while a mounted television provides entertainment options.
Home in Semmes
4.94 out of 5 average rating, 89 reviews

Spacious 4 bedroom/2 bath in Sweet Home Alabama

Cozy up to the fireplace in this beautiful 4 bedroom/2 bath house in Sweet Alabama. Completely renovated and furnished to sleep up to 8 guests. Oversized master bedroom and bathroom with a big tub to relax in. Complimentary towels, dishes, glasses and coffeemaker with coffee. Centrally located near Historical homes, museums, parks and botanical garden. 10 min. from Mobile airport. 15 min. from Cruise Terminal. *You get 10% off your entire stay if you book for 7 Nights!

Top guest favorite
Tiny home in Semmes
4.93 out of 5 average rating, 87 reviews

Peaceful Backyard Suite

Enjoy the sounds of nature when you stay in this unique place. Shade trees can be seen through the fixed windows near the cathedral ceiling. Feels as though you are in a treehouse! Bedroom has one queen bed & can be closed off from kitchen & living room. House is new and within a fenced yard. It’s to the rear of owner’s home and backs up to a flower nursery. Very quiet. Great place to study, work online, or just relax. Swing on Front Porch. Pets for short term. No cats.

Superhost
A bright bedroom features a spacious bed with an arrangement of decorative pillows. Soft sunlight filters through sheer curtains at two windows, while bedside tables hold lamps. A dresser with decorative accents is positioned against one wall, adding to the room's relaxed ambiance.
Cottage in Mobile
4.91 out of 5 average rating, 267 reviews

The Cottage on Clearmont

Welcome to The Cottage on Clearmont where convenience meets comfort. Enjoy the privacy and comfort of this fully-furnished, two bedroom, one bath, completely renovated cottage in the heart of Midtown! The cottage is perfectly situated and dog friendly, making it easy to experience the best dining and shopping Mobile has to offer! We live close by and will be happy to help with any questions you may have regarding the cottage or Mobile and surrounding areas.

Superhost
A charming blue house features a welcoming front porch with white railings and steps. Colorful flags, including a Mardi Gras flag, hang from the porch. Lush green grass and plants are visible in the well-maintained yard, enhancing the overall appeal of the entrance.
Home in Mobile
4.84 out of 5 average rating, 328 reviews

House of Blues Mobile AL Mardi Gras Creole Cottage

Enjoy a couple nights in the Festive Midtown/Downtown of Mobile Alabama OR stay for an extended period of time if you come for Mardi Gras or for work at one of the 4 hospitals. SO close to the fun... just minutes from Dauphin Street restaurants, bars and all of the cultural events and locations that makes Mobile so unique. Historic charm with all of the conveniences of home. Our goal is to make new friends each time the House of Blues has a guest!

Guest favorite
An A-frame cabin is depicted alongside a spacious dock with a covered area. Soft lights are strung around the dock, illuminating the serene water surrounded by trees at sunset. The peaceful landscape reflects a calming atmosphere.
Cabin in Satsuma
4.9 out of 5 average rating, 211 reviews

Secluded cabin on the water jetski, kayak & hottub

Mobile’s number 1 STAYCATION!!! Private waterfront A-frame cabin—your perfect tranquil getaway. Enjoy a huge dock, hot tub, and stunning views in a peaceful, secluded setting. Calm clean waters with jet ski, kayak, boat & hydro bike rentals (seasonal). Cozy 1-bedroom loft, pet-friendly, and great fishing. Just 20 mins from Mobile and 1 hour from beaches & casinos—privacy with convenience! Experience a one of a kind experience

Popular amenities for Semmes vacation rentals