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Vacation rentals in Santa Maria

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Top-rated vacation rentals in Santa Maria

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A modern kitchen features a spacious island with three high-backed bar stools. The countertops are light-colored, complemented by dark cabinetry and a decorative backsplash. Stainless steel appliances are visible, and a small tray with flowers is placed on the island.
Condo in Mercedes
4.94 out of 5 average rating, 143 reviews

Quiet huge 4 bed condo 2 miles by the Outlets!

Centrally located in the Rio Grande Valley. This quiet 3 bedroom condominium is a shoppers paradise only two miles away from the Mercedes Outlets! Travel into the most tourist friendly border city in Mexico, the city of Progreso, only 10 miles away! Head to the beach at South Padre Island, about 50 miles away. Be mesmerized by Elon's Space X at Boca Chica Beach 67 miles away! Level 2 charging outlet (nema 14-50R) reserved for you, bring your own EV charger. Unlimited free parking on premises.

Top guest favorite
Home in Harlingen
5 out of 5 average rating, 22 reviews

Charming 3 Bed in Harlingen’s Newest Subdivision

Charming 3-Bedroom Retreat in Harlingen, TX 3418 Penelope Drive! Welcome to your home away from home in the heart of Harlingen! This spacious 3-bed, 2.5-bath getaway is perfect for families, friends, or business travelers seeking comfort and convenience. Whether you’re exploring local attractions, planning a beach day, or simply relaxing on the deck, this Harlingen retreat offers a perfect balance of comfort, convenience, and Texas charm. I’d love to host your stay and help you create memories!

Top guest favorite
An open living area features a spacious brown sectional sofa, accompanied by a coffee table, over a textured area rug. Large glass doors provide seamless access to the outdoor space, while modern pendant lights hang above a sleek kitchen island in the background.
Home in Edinburg
4.99 out of 5 average rating, 101 reviews

The Serene Home

Welcome to our Serene Home, where tranquility meets luxury for the ultimate escape. Nestled in the heart of Edinburg, this vacation home is a haven for those seeking a peaceful and rejuvenating gateway. The design blends Japanese with elements of zen-inspired architecture, creating a harmonious space that fosters relaxation. Natural light floods through large windows, illuminating the open living spaces. Embrace the serenity, and create lasting memories in this peaceful vacation home.

Guest favorite
A single-story brick home is set on a grassy lawn, surrounded by palm trees. A white mailbox stands at the forefront, displaying the house number. Sidewalks lead to the entrance, which features a round window and a covered porch.
Home in Weslaco
4.93 out of 5 average rating, 102 reviews

Weslaco Home - Calm & quaint cozy retreat

Home has Wifi and Firestick. Home is located close to the RGV Premium Outlet Mall, Nuevo Progreso Mx., RGV Rodeo Livestock Grounds, Wesmer Drive-in and just a short drive to South Padre Island, Gladys Porter Zoo, Laguna Atascosa National Wildlife Refuge, Basilica Of Our Lady of San Juan del Valle-National Shrine, McAllen Simon Mall & Convention Center, Quinta Mazatlan birding sanctuary, Santa Ana Refuge, Bentsen State Park, Falcon State Park. Bert Ogden & Payne Hidalgo Arenas.

Top guest favorite
Guest suite in Harlingen
4.95 out of 5 average rating, 282 reviews

Entire Private and Relaxing Apartment

Enjoy this relaxing and PRIVATE apartment in a beautiful country club. You'll have peace of mind as you stay in a quiet neighborhood close enough to the city to get to where you need yet far away enough to enjoy serenity. This unique one bedroom apartment has an attached living room which has been converted to a recreation room with a couch, tv, sink, and other kitchenette essentials. Enjoy free coffee and Wi-Fi! An outdoor patio also awaits for you to listen to nature.

Guest favorite
A single-story home featuring a brick façade and a manicured front yard. Two palm trees stand nearby, while a concrete driveway accommodates multiple vehicles. Windows are framed by greenery, creating a welcoming exterior view under a partly cloudy sky.
Home in Weslaco
4.94 out of 5 average rating, 152 reviews

My House

Mi Casa Tu Casa Weslaco Tx, a small city that has everything. Enjoy every moment in this home that is made especially for you!.. 16 Minutes to Progreso bridge (Progreso México) 16 Minutes to Donna bridge (México Rio bravo) 31 Minutes to Valley International Airport (Harlingen tx) 23 Minutes to Mcallen International Airport and Plaza Mall 13 Minutes to Rio grande Valley Premium Outlet 6 Min from 83 Hwy 1:12 Min to south Padre island via 1-2

Guest favorite
A charming guesthouse exterior is framed by a neat garden bed featuring potted plants and decorative stones. The well-maintained pathway leads to a welcoming door, complemented by two windows that allow natural light to fill the interior spaces.
Guesthouse in Harlingen
4.84 out of 5 average rating, 209 reviews

Harlingen Guesthouse with a Pool

This place is a guesthouse located at the outskirts of Harlingen Texas. Very peaceful being it is out of city limits but still very close to restaurants, shopping etc. Just a 4 minute drive. You will have access to the pool and outdoor furniture as well as a charcoal grill. It is also a 45 minute drive to South Padre Island and 35 minute drive to the big city of Mcallen, Tx. and 15 minutes away from the outlets in Mercedes Tx.

Top guest favorite
A welcoming living room features a blue sofa with decorative pillows, flanked by two wooden side tables holding lamps. A neutral-colored area rug lies beneath a wooden coffee table, surrounded by a plush armchair and two textured poufs, while soft light fills the spacious area.
Guesthouse in Harlingen
4.99 out of 5 average rating, 102 reviews

Peaceful Country Getaway

This private, cozy guest house is next to our home and includes a bedroom, bathroom, full kitchen, and living room. It has a beautiful view of our 2.4 acre property. Amenities include a queen size bed, WiFi, refrigerator, oven, microwave, coffee maker and much more. Valley Baptist Medical Center–12 minutes Valley International Airport-15 minutes Brownsville–30 minutes McAllen–35 minutes South Padre Island–50 minutes

Guest favorite
Home in Mercedes
4.9 out of 5 average rating, 165 reviews

Shop, swim, & relax private pool 3 min to outlets

Private pool Newly remodeled and furnished ready to make your stay as comfortable and convenient as possible! right off the expressway across from the outlet mall (3 minute drive) , 20 minutes away from McAllen, and 40 minutes away from South Padre Island! 5 minutes away from stock show grounds. Home sits on 1/2 acre in a quiet and peaceful neighborhood! 2 queen beds 2 twin beds Fold out sofa

Guest favorite
A spacious living area features a dark leather sectional sofa, paired with a sleek black recliner. Natural light fills the room through three windows, while a central coffee table stands between the seating. Decorative plants and modern light fixtures add a contemporary touch.
Apartment in Weslaco
4.92 out of 5 average rating, 136 reviews

Modern comfortable retreat in gated community!

Minutes away from the outlet mall, the Progreso International bridge & much more. Perfectly located in the mid valley so you can decide if you want a beach day or a shopping day!! We welcome long term guests, medical visits, corporate visits etc. We want you to feel as comfortable as possible while you stay with us! Enjoy the best AirBNB experience available!

Guest favorite
Home in Mercedes
4.91 out of 5 average rating, 56 reviews

Sleeps 10 | Game Room + Pool Table | Truck Parking

Restful and apacious 3BR/2BA home in Mercedes, TX — sleeps 10 for less than two hotel rooms. Built for families, work crews, nurses, and road-trippers exploring the Rio Grande Valley. Base rate covers up to 4 guests. Additional guests just $12/night — still a fraction of booking multiple hotel rooms.

Guest favorite
Apartment in Weslaco
5 out of 5 average rating, 10 reviews

Executive Suite

Enjoy your private suite designed for comfort and productivity. Enjoy two full bathrooms, a private office for remote work, and a stylish open living space ideal for short or extended stays. Perfect for professionals seeking peace, privacy, and convenience. It's a four-minute drive to the expressway.

Popular amenities for Santa Maria vacation rentals

  1. Airbnb
  2. United States
  3. Texas
  4. Cameron County
  5. Santa Maria