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House vacation rentals in Santa Fe de Antioquia

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Top-rated house rentals in Santa Fe de Antioquia

Guests agree: these houses are highly rated for location, cleanliness, and more.

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Top guest favorite
The image displays a modern house with a two-level design, surrounded by serene outdoor spaces. A sparkling pool with a jacuzzi is seen adjacent to a dining area furnished with a table and chairs. Soft lighting enhances the inviting ambiance during twilight.
Home in Santa Fe de Antioquia
4.91 out of 5 average rating, 280 reviews

¡Exclusive villa with private pool and jacuzzi!

Exclusive house with a private pool and jacuzzi (Rates from 6 to 10 people), spacious, modern, with luxurious finishes, and fully equipped for a very comfortable stay. An ideal place to relax, unwind, and share unforgettable moments with family, friends, or couples. Located two blocks from the main park of Santa Fe de Antioquia, a magical place of great historical and cultural richness, its colonial architecture and cobblestone streets, which are still preserved, are national heritage sites.

LocationValueWifi

Superhost
Home in Santa Fe de Antioquia
4.82 out of 5 average rating, 68 reviews

Cabin in Santa Fe de Antioquia

Escape to this beautiful estate just 7 minutes from the historic center of Santa Fe de Antioquia, near the iconic Puente de Occidente. Relax while you’re on the terrace, in the pool, or in the hot tub, with a spectacular view of the mountains and an environment surrounded by nature. Capacity for 12 people. It has air conditioning, Wi-Fi, a fully equipped kitchen, a BBQ area, furnished spaces, and private parking. Ideal for rest and spending time with family, friends, or your partner.

LocationValueAmenities

Guest favorite
Two white lounge chairs are positioned near a round, tiled jacuzzi surrounded by vibrant flowering plants. A shaded patio set and umbrella are visible in the background, adding to the inviting outdoor space. Bright blue skies create a cheerful atmosphere.
Home in Santa Fe de Antioquia
4.89 out of 5 average rating, 215 reviews

Beautiful Colonial House in Santa Fe, Antioquia, A/C

Beautiful and cool colonial house in Santa Fe de Antioquia, 4 spacious rooms with A/C, common areas, and a jacuzzi. Great location. Just two blocks from the main park. Two cool and spacious patios for enjoyment. 950 m2 of built-up area. It is a space for families looking for a private, central location where you won't be affected by noise, where everything will be close by, and where you can enjoy all the amenities of this beautiful colonial city.

ValueLocationQuiet

Guest favorite
Home in Santa Fe de Antioquia
4.88 out of 5 average rating, 52 reviews

Entire accommodation with private Jacuzzi in Santa Fe

Discover this cozy two-bedroom apartment, ideal for families or friends. One of the bedrooms has air conditioning for your comfort. Enjoy movie nights with the projector in the room and fully stocked kitchen to prepare your favorite dishes. You will also have access to a laundry area. Located just two blocks from the main park, you will be close to restaurants and local attractions. Come and enjoy the magic of Santa Fe de Antioquia!

FamilyLocationHospitality

Guest favorite
Home in Santa Fe de Antioquia
4.88 out of 5 average rating, 178 reviews

Your resting place in Santafé de Antioquia

Our rest house offers comfort and style with 2 bedrooms, 2 bathrooms and an atmosphere designed to share with those you love the most. Residential area, safe and a few minutes from the historic center, easy access to everything you need 🌿🏠☀️ publication cost valid for 2 people, capacity for a maximum of 5 people. THANK YOU FOR CHOOSING US 🏠🌿 Important: We are not a hotel 🤗

ValueLocationNearby

Guest favorite
An outdoor area features a jacuzzi set against soft pink walls. Seating is arranged around a large table, complemented by several green chairs. Ceiling fans are visible, and plants are suspended above. A doorway leads to an interior space that is softly illuminated.
Home in Santa Fe de Antioquia
4.89 out of 5 average rating, 53 reviews

Casa La Batuta. Beautifully restored.

Two blocks from La Chinca Park. A place close to the heritage heart of the village. The house, high ceiling and tapia walls, has a capacity for 10 people, accommodated in 3 spacious bedrooms with bathroom. And a romantic and cozy social area with an outdoor hot tub. THE BASE RATE APPLIES FOR UP TO 2 PEOPLE; THERE IS A CHARGE PER NIGHT FOR EACH ADDITIONAL PERSON.

FamilyValueIndoor spaces

Guest favorite
The two-story house features a modern design, with large glass panels and a balcony. A spacious outdoor area includes a private pool and a covered dining space, creating an inviting environment. Palm trees are visible in the background, enhancing the overall ambiance.
Home in Santa Fe de Antioquia
4.93 out of 5 average rating, 143 reviews

Linda Villa in Santa Fe de Antioquia

Relax with the whole family in this quiet place. It is a beautiful house with a private pool two blocks from the main park of Santa Fe de Antioquia. This house is ideal for 10 people with large spaces. • The rates described here, are for 6 people. Each additional person, is priced at $82,000 per person per night. Sleeps up to 10 guests. There is no hot water.

ValueLocationTV

Guest favorite
A private pool area is highlighted by a sleek blue swimming pool and an adjacent jacuzzi, both illuminated by soft lighting. Comfortable outdoor seating is provided, surrounded by lush greenery against a modern stone wall.
Home in Santa Fe de Antioquia
4.95 out of 5 average rating, 102 reviews

Luxury house with private pool and Jacuzzi!

Exclusive wet area (swimming pool and jacuzzi heated with hot water), green area, gas grill and barrel (maximum 12 people). You can enjoy a quiet, comfortable, spacious, safe atmosphere, with luxury finishes and fully equipped during your stay in which you can relax and spend unforgettable moments with your family and friends.

FamilyLocationHospitality

Superhost
Home in Santa Fe de Antioquia
4.89 out of 5 average rating, 161 reviews

Farm in Santa Fe with panoramic view

QUEEN is a modern estate in Santa Fe de Antioquia with panoramic views, perfect for resting or celebrating. It has 5 rooms with private bathroom, luxury pool, BBQ area, and a spectacular set of lights. Just 10 minutes from the historic center. Great for families, groups of friends, or special events (check before).

LocationValueSleep quality

Superhost
A private pool is seen surrounded by lounge chairs and tropical plants. The sleek modern design of the home's facade is complemented by an outdoor dining area under an expansive canopy. Lush greenery provides a serene backdrop to this inviting outdoor space.
Home in Santa Fe de Antioquia
4.86 out of 5 average rating, 259 reviews

Beautiful house in Santafe de Antioquia

Renovated in July 2026, this beautiful house has modern spaces and is ideally equipped for resting and spending unique moments. Just two blocks from the park, with a swimming pool and large gardens, a house with all the necessary equipment to have the best experience. Our customers' favorite house in 2026.

LocationFamilyAccuracy

Guest favorite
A serene outdoor space is highlighted by a rectangular jacuzzi surrounded by lush greenery and flowering plants. The soft blue water contrasts with the warm tones of the surrounding walls, while a bright sky with clouds enhances the tranquil atmosphere.
Home in Santa Fe de Antioquia
4.96 out of 5 average rating, 79 reviews

Casa Polonia, luxury lodging

CASA POLONIA is a luxury retreat in the most exclusive area of Santa Fe de Antioquia’s historic center. Its 200-year-old colonial architecture features high ceilings, adobe walls, stone courtyards, and unique details. A private oasis where history, charm, and comfort come together for an unforgettable stay.

FamilyLocationPool

Guest favorite
Home in Santa Fe de Antioquia
4.77 out of 5 average rating, 101 reviews

Casa Colonial Arce y Toral - Santa Fe de Antioquia

It is a space inherited from our ancestors, of joy and remembrance; with a colonial decoration, ideal to enjoy the culture and have a good rest. The house has a maximum capacity of 6 people, and it has a fully-equipped kitchen, board games, Wi-Fi, and Netflix for your entertainment.

LocationValueWalkability

Popular amenities for Santa Fe de Antioquia house rentals