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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Apartment in Roma Norte
5 out of 5 average rating, 12 reviews

Magical For 6 Rome, balcony, washing machine, desk

Enjoy a unique experience in the heart of North Rome, steps from Álvaro Obregón, the most iconic and lively avenue in the colony, covered by trees and full of terraces, galleries and local life. ✔ 🌳 Balcony with green views ✔ ☕️ Dozens of signature restaurants, specialty cafes, independent bookstores, designer boutiques and parks full of life, all on foot, without the need for uber. ✔ King Size Bed ✔ Washer dryer ✔ 2nd floor in a building without elevator Fell in love with the best of Mexico!

Guest favorite
A sunlit corner features large floor-to-ceiling windows offering views of greenery outside. A dark wooden table is accompanied by two cushioned seats, while a cozy seating area with a collection of books and decorative items is situated nearby, contributing to a serene environment.
Apartment in Condesa
4.88 out of 5 average rating, 130 reviews

Kaya Kalpa-Organic Designer Apartment in Condesa

After a year-long remodeling project, I’m thrilled to present this personal residence Kaya Kalpa. Every inch of the property has been thoughtfully remodeled. Ideal place for artists, wanderers, all walks of life practitioners to come reset, reflect, and create.  The space is located on Amsterdam street in Condesa, one block from Parque Mexico. You’ll find all nice restaurants, cafes, and stores downstairs. Big supermarket, local Mercado, metro station…all within 5 minutes walking distance.

Guest favorite
Loft in Roma Norte
5 out of 5 average rating, 15 reviews

Iconic Designer double-height loft

KAAN KIN en un loft de doble altura en el corazón de Roma Norte. Arquitectura excepcional, interiorismo de autor y cada rincón impecable. Completamente equipado: pantalla de 75", sistema de audio Sonos, Wi-Fi de alta velocidad y Aire acondicionado. A pasos de los mejores restaurantes, cafeterías y parques. Comunicación directa y cada detalle resuelto antes de tu llegada. Una residencia con el cuidado de un hotel boutique pensada para quienes buscan una experiencia de primer nivel.

Guest favorite
A spacious living area is depicted, featuring a round glass dining table surrounded by six woven chairs. A wooden bookshelf filled with books is visible in the background, along with a comfortable seating area containing a dark sofa. A large television is mounted on the wall.
Loft in Xochimilco
4.92 out of 5 average rating, 88 reviews

Beautiful suite with a separate entrance

Relax on this unique and quiet getaway in this beautiful space surrounded by nature. Beautiful garden and architecture. Close to attractions in Xochimilco such as the trajineras and the canals and chinampas of Xochimilco and Cuemanco. Traditional village south of the city. Relax in our beautiful place, surrounded by nature. Beautiful green garden and architecture. Close to main attractions like Trajineras, Xochimilco town, canals and chinampas. Traditional town south of the city

Guest favorite
A spacious rooftop terrace is highlighted with a covered seating area, featuring a low table and cushioned seating. Lush green plants are dotted around, adding a natural touch. Soft lighting is suspended above, creating an inviting environment. A wooden privacy wall is partially visible in the background.
Home in Xochimilco
5 out of 5 average rating, 10 reviews

Roof & SmartHouse in Xochimilco Enjoy•Live•Relax

Stay in a stylish, fully equipped smart home designed for comfort and convenience. Enjoy your own private rooftop garden, perfect for morning coffee, sunset drinks, or relaxing after the match. Your stay includes: ✓ Fully equipped kitchen ✓ Washer ✓ Fast WiFi ✓ Private parking ✓ Smart home amenities ✓ Great access to transportation and main roads Conveniently located near Estadio Azteca, Coyoacán, and Xochimilco, with easy access to public transit, restaurants and cafés.

Guest favorite
A spacious living area features a high ceiling and exposed brick walls, illuminated by soft lighting. A large mirror hangs above a simple coffee table, surrounded by a cozy sofa and two armchairs. Indoor plants add a touch of nature to the inviting space.
Casa particular in Álvaro Obregón
4.94 out of 5 average rating, 32 reviews

My San Angel Refuge

Mi Refugio San Angel, is a spacious and modern space, to feel out of the city, being centrally in it. It has a Temazcal (under reservation), hydromassage tub, terraces, garden with hammocks, lounge chair, outdoor dining area, bonfire area, indoor fireplace. 2 rooms with full bathroom, queen size sofa bed; open, spacious and fully equipped kitchen. Private parking. The main room can be opened to a view towards the double height of its large room.

Superhost
A cozy bedroom features a spacious bed with a soft grey headboard and decorative cushions. A sleek bedside lamp provides gentle illumination, while modern wooden cabinetry adds warmth to the space. A grey armchair is positioned nearby, complemented by delicate white flowers in the foreground.
Loft in Tlalpan
4.88 out of 5 average rating, 920 reviews

Punto Lofts Periférico Sur (South Peripheral Point Lofts)

Punto Lofts Periférico Sur is a modern concept with 18 fully equipped lofts, ideal for short or long stays. Each loft accommodates up to 3 people and has a queen size bed and sofa bed, offering comfort and rest. Enjoy 24/7 reception, digital key access, and high standards of cleanliness and safety. Located on Periférico Sur, opposite the Azteca Stadium, with easy access to hospitals, restaurants and shopping centers.

Top guest favorite
Loft in Ayapango de Gabriel Ramos M.
5 out of 5 average rating, 19 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

Guest favorite
Cabin in Tlalmanalco de Velázquez
5 out of 5 average rating, 12 reviews

A little house near the volcanoes.

Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.

Guest favorite
An outdoor terrace is presented with a wooden pergola, casting dynamic shadows across a spacious wooden dining table surrounded by benches. A kitchen area is visible with a modern design, and various potted plants are arranged along the perimeter, enhancing the natural ambiance.
Loft in Coyoacán
4.94 out of 5 average rating, 642 reviews

ECO-ROOF with terrace in the heart of Coyoacán

Nice and cozy room with a private balcony in the heart of Coyoacán, one of the most picturesque and traditional neighborhoods in Mexico City. Located a 5-minute walk from downtown Coyoacan, traditional restaurants, cafes, craft bazaars, and museums.

Top guest favorite
The exterior of a two-story house is surrounded by lush greenery and vibrant planters. A small terrace features a white umbrella, where a person is seated, enjoying the garden view. A paved pathway leads to the entrance, enhancing the welcoming atmosphere.
Loft in Del Carmen
4.95 out of 5 average rating, 256 reviews

Loft Coyoacan Viveros (Bow)

A super special and very cozy place in the heart of Coyoacán! right next to Coyoacán nurseries, on Melchor Ocampo street Ideal for a couple with or without children who want to enjoy a pleasant stay or a good walk through the wonders of Coyoacán :)

Top guest favorite
A spacious living area features a light grey sofa adorned with decorative pillows. An intricate glass coffee table sits on a tiled floor, reflecting light from large windows framed by brick arches. Warm curtains complement the vibrant wall art and ceramic plates displayed nearby.
Home in Coyoacán
4.96 out of 5 average rating, 159 reviews

Colonial house with garden in the center of Coyoacán

Luxury colonial house, 350 meters from the center of Coyoacan. The house has a garden and terrace. We strive to make your stay perfect. If your stay is long, we have cleaning service included.

Popular amenities for Santa Cruz vacation rentals

  1. Airbnb
  2. Mexico
  3. Santa Cruz