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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Loft in Iztapalapa
5.0 out of 5 average rating, 29 reviews

Private Microsuite Const 1917 Iztapalapa

Beautiful and modern private microsuite in the east of CDMX, ideal for couples, business trips, family visits or relaxation. It has a double bed, full bathroom, Wi-Fi, desk, TV, closet and kitchenette with sink. Near Constitución de 1917, with connections to the Metro, Trolebús Elevado and Cablebús. If you come for work, you can request a coworking space or a professional room at Punto de Negocios, across from the accommodation, subject to availability through Airbnb. Your private base for getting around better.

Guest favorite
A sunlit corner features large floor-to-ceiling windows offering views of greenery outside. A dark wooden table is accompanied by two cushioned seats, while a cozy seating area with a collection of books and decorative items is situated nearby, contributing to a serene environment.
Apartment in Condesa
4.89 out of 5 average rating, 132 reviews

Kaya Kalpa-Organic Designer Apartment in Condesa

After a year-long remodeling project, I’m thrilled to present this personal residence Kaya Kalpa. Every inch of the property has been thoughtfully remodeled. Ideal place for artists, wanderers, all walks of life practitioners to come reset, reflect, and create.  The space is located on Amsterdam street in Condesa, one block from Parque Mexico. You’ll find all nice restaurants, cafes, and stores downstairs. Big supermarket, local Mercado, metro station…all within 5 minutes walking distance.

Guest favorite
A spacious living area is depicted, featuring a round glass dining table surrounded by six woven chairs. A wooden bookshelf filled with books is visible in the background, along with a comfortable seating area containing a dark sofa. A large television is mounted on the wall.
Loft in Xochimilco
4.91 out of 5 average rating, 89 reviews

Beautiful suite with a separate entrance

Relax on this unique and quiet getaway in this beautiful space surrounded by nature. Beautiful garden and architecture. Close to attractions in Xochimilco such as the trajineras and the canals and chinampas of Xochimilco and Cuemanco. Traditional village south of the city. Relax in our beautiful place, surrounded by nature. Beautiful green garden and architecture. Close to main attractions like Trajineras, Xochimilco town, canals and chinampas. Traditional town south of the city

Guest favorite
A well-maintained garden is surrounded by stone structures and lush greenery. Towering cypress trees frame the area, while flower beds add color to the landscape. Clear blue skies and soft clouds enhance the peaceful atmosphere of the outdoor space.
Cottage in Mexico City
5.0 out of 5 average rating, 22 reviews

Stay in a beautiful country estate.

Beautiful Hacienda Campestre in Milpa Alta, Mexico City, ideal for disconnecting from the hustle and bustle and being in contact with nature in a quiet and safe place. The property is located 25 minutes from the Xochimilco sports complex in the mountains. We are only 10 minutes from the magical neighborhood of San Pedro Atocpan. It has parking for several cars, a barbecue area, a beautiful campfire area, mini goals and an inflatable for young children. We are pet friendly.

Guest favorite
A spacious living area features large windows that provide abundant natural light and stunning city views. A comfortable sofa is positioned near a coffee table, with a TV unit against the wall. A staircase leads to the upper level, enhancing the open layout.
Condo in Álvaro Obregón
4.94 out of 5 average rating, 157 reviews

Celebrate Mexican festivities in PH with Amenities

Get ready to appreciate the city from an exclusive PH on the 32nd floor. Whether for pleasure or business, take advantage of the amenities this space has to offer. Exercise in the gym and then work for a while in the business center, have a snack in the restaurant, relax with a massage in the SPA and enjoy an incredible view in the terrace pool, without leaving your space! Near the building, you will find main roads and a shopping plaza for your shopping. Welcome!

Superhost
An open-plan living area features a dining table with black chairs and a contrasting wooden surface. Natural light floods the space through large windows, illuminating a relaxed seating area and green plants. Decorative wall pieces add character to the minimalist design.
Loft in Coyoacán
4.88 out of 5 average rating, 226 reviews

Casa Mavi's loft in Coyoacán

Welcome to Coyoacán! Great 120 m2 loft located just a 5-minute walk from downtown Coyoacán. Experience this quiet and bright open space, ideal for resting or working and decorated with objects full of stories. The loft is located on the third floor of Casa Mavi, an old factory that was remodeled to create a place full of charm that makes it unique. It has shared terraces. With option for a third guest. 200 megabyte Wi-Fi.

Superhost
A cozy bedroom features a spacious bed with a soft grey headboard and decorative cushions. A sleek bedside lamp provides gentle illumination, while modern wooden cabinetry adds warmth to the space. A grey armchair is positioned nearby, complemented by delicate white flowers in the foreground.
Loft in Tlalpan
4.88 out of 5 average rating, 933 reviews

Punto Lofts Periférico Sur (South Peripheral Point Lofts)

Punto Lofts Periférico Sur is a modern concept with 18 fully equipped lofts, ideal for short or long stays. Each loft accommodates up to 3 people and has a queen size bed and sofa bed, offering comfort and rest. Enjoy 24/7 reception, digital key access, and high standards of cleanliness and safety. Located on Periférico Sur, opposite the Azteca Stadium, with easy access to hospitals, restaurants and shopping centers.

Top guest favorite
Loft in Ayapango
5.0 out of 5 average rating, 19 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

Superhost
A tranquil pond surrounded by trees features three ducks leisurely swimming. The water reflects the greenery, creating a calm and natural setting. The landscape includes dry earth and grasses, indicative of the outdoor environment.
Cottage in Tlalpan
4.92 out of 5 average rating, 52 reviews

La Ciruelita - Country house with fireplace

Relax with the whole family in this accommodation where tranquility is breathed. You can cook in the pizza oven, play tennis, go to the tree house, or rest by walking among the cherry trees in the 6000 square meters of completely fenced land. At night you can make a campfire and see the stars from the inside through the skylights. A cozy atmosphere in the woods that will revitalize you.

Guest favorite
Cabin in Tlalmanalco
5.0 out of 5 average rating, 12 reviews

A little house near the volcanoes.

Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.

Guest favorite
A modern living area features a combination of comfortable grey sofas and a dining table. Soft blue and beige tones enhance the space, with decorative wall art complementing the minimalist design. Large windows with horizontal blinds allow natural light to illuminate the room.
Home in Xochimilco
5.0 out of 5 average rating, 12 reviews

SmartHome & Rooftop in Xochimilco-Enjoy Live Relax

Stay in a fully equipped luxury apartment designed for comfort and convenience. Unwind on your private rooftop terrace and enjoy a Smart Home experience. Your stay includes a fully equipped kitchen, washer, high-speed WiFi, and free parking. Ideally located near Xochimilco’s Historic Center, with easy access to public transportation, restaurants, cafés, and the city’s main roads.

Top guest favorite
A charming outdoor patio is surrounded by vibrant greenery and a blue-walled house. A round glass table is complemented by six white metal chairs, creating an inviting space for dining or gathering. Potted plants and flowers add color to the serene environment.
Home in Coyoacán
4.97 out of 5 average rating, 109 reviews

Casa Omac | Colonial house with two patios

Typical colonial house, located in the most picturesque and emblematic street of Coyoacán. The style is reminiscent of Frida Kahlo's Blue House, which is a few minutes' walk away. Organized around a large internal patio, the house has 5 double rooms and can host up to 10 people, making it ideal for groups and families.

Popular amenities for Santa Cruz vacation rentals