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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A private rooftop space is showcased, featuring a wooden ceiling with overhead lighting. Comfortable seating is provided along with a dining area, outlined by tall bar stools. An elephant statue adds a decorative touch, with a view of the city skyline in the background.
Condo in Condesa
4.92 out of 5 average rating, 123 reviews

Apartment Penthouse Great View in Condesa Ciudad de Mexico

A marvelous rooftop with stunning and cozy bedrooms awaits you. You can rest in our beautiful living room or you can go up and have unforgettable moments on a private rooftop, equipped with a professional kitchen and barbecue for that special dinner while lounging in the shade of our custom glass-top enjoy the beautiful city lights. One year young, spacious penthouse for rent in the beautifully coveted neighborhood of La Condesa in México City. It has a wonderful private rooftop garden with an incredible view of the city. The apartment is within walking distance of excellent eateries, shops, bars and a great farmers market on Tuesdays and Saturdays. It is of walking distance to popular tourist attractions. We know you will fall in love with this apartment enough to make it your home here on Mexico City. Details: 6th floor with elevator access 24/7 security cameras 1 parking spot Private entrance Fully furnished with high quality furniture 3 furnished bed rooms with private bathrooms 1 sofa bed in living room Door men 24 hours available 2 parking spaces We do have contact direct number door men available for guests The Penthouse is located at Condesa, one of Mexico City’s fashionable neighborhoods. By walking some blocks you'll find designer boutiques and excellent cafés. Fan of food? You'll find an amazing offer of great restaurants: from contemporary Mexican cuisine, to Argentinian, Italian or French options. Are you the runner type? Condesa has friendly spaces for jogging and beautiful parks to enjoy the afternoon. Bike, and walk distance to the restaurants and bars

Top guest favorite
Loft in Iztapalapa
5.0 out of 5 average rating, 29 reviews

Private Microsuite Const 1917 Iztapalapa

Beautiful and modern private microsuite in the east of CDMX, ideal for couples, business trips, family visits or relaxation. It has a double bed, full bathroom, Wi-Fi, desk, TV, closet and kitchenette with sink. Near Constitución de 1917, with connections to the Metro, Trolebús Elevado and Cablebús. If you come for work, you can request a coworking space or a professional room at Punto de Negocios, across from the accommodation, subject to availability through Airbnb. Your private base for getting around better.

Guest favorite
A sunlit corner features large floor-to-ceiling windows offering views of greenery outside. A dark wooden table is accompanied by two cushioned seats, while a cozy seating area with a collection of books and decorative items is situated nearby, contributing to a serene environment.
Apartment in Condesa
4.89 out of 5 average rating, 131 reviews

Kaya Kalpa-Organic Designer Apartment in Condesa

After a year-long remodeling project, I’m thrilled to present this personal residence Kaya Kalpa. Every inch of the property has been thoughtfully remodeled. Ideal place for artists, wanderers, all walks of life practitioners to come reset, reflect, and create.  The space is located on Amsterdam street in Condesa, one block from Parque Mexico. You’ll find all nice restaurants, cafes, and stores downstairs. Big supermarket, local Mercado, metro station…all within 5 minutes walking distance.

Top guest favorite
A welcoming living area is highlighted by wooden flooring and large windows allowing natural light to fill the space. Two armchairs are positioned in front of a coffee table, where a book about mural painting is visible. A fireplace provides a cozy focal point in the background.
Home in Del Carmen
4.95 out of 5 average rating, 388 reviews

Casa José Clemente Orozco Coyoacán

Located in Coyoacán, typical Mexican neighborhood surrounded by markets, museums and historical buildings, a few blocks from Museu Frida Khalo, this house was the first studio for the painter and muralist José Clemente Orozco, who designed and build it between 1921 and 1923. All the bedrooms have their own bathroom and the main suite has a king-size bed, Smart TV and a terrace. It has a big and beautiful garden and a work space with its own terrace too. The garden is shared by 2 houses.

Guest favorite
A spacious living area is depicted, featuring a round glass dining table surrounded by six woven chairs. A wooden bookshelf filled with books is visible in the background, along with a comfortable seating area containing a dark sofa. A large television is mounted on the wall.
Loft in Xochimilco
4.91 out of 5 average rating, 89 reviews

Beautiful suite with a separate entrance

Relax on this unique and quiet getaway in this beautiful space surrounded by nature. Beautiful garden and architecture. Close to attractions in Xochimilco such as the trajineras and the canals and chinampas of Xochimilco and Cuemanco. Traditional village south of the city. Relax in our beautiful place, surrounded by nature. Beautiful green garden and architecture. Close to main attractions like Trajineras, Xochimilco town, canals and chinampas. Traditional town south of the city

Guest favorite
Casa particular in Álvaro Obregón
4.94 out of 5 average rating, 32 reviews

My San Angel Refuge

Mi Refugio San Angel, is a spacious and modern space, to feel out of the city, being centrally in it. It has a Temazcal (under reservation), hydromassage tub, terraces, garden with hammocks, lounge chair, outdoor dining area, bonfire area, indoor fireplace. 2 rooms with full bathroom, queen size sofa bed; open, spacious and fully equipped kitchen. Private parking. The main room can be opened to a view towards the double height of its large room.

Superhost
Home in Tlalpan
4.93 out of 5 average rating, 14 reviews

Pedregal Garden House

Beautiful home with a private pool and garden in Fuentes del Pedregal, just minutes from Hospital Ángeles and Artz Pedregal. Ideal for families or groups, with 3 bedrooms, 4 beds, and space for up to 8 guests. The house features 2 full bathrooms, a fully equipped kitchen, dining area, laundry, and parking. Enjoy the patio, lush greenery, and pool in a quiet, private setting with an excellent location in the south of Mexico City.

Superhost
A cozy bedroom features a spacious bed with a soft grey headboard and decorative cushions. A sleek bedside lamp provides gentle illumination, while modern wooden cabinetry adds warmth to the space. A grey armchair is positioned nearby, complemented by delicate white flowers in the foreground.
Loft in Tlalpan
4.88 out of 5 average rating, 925 reviews

Punto Lofts Periférico Sur (South Peripheral Point Lofts)

Punto Lofts Periférico Sur is a modern concept with 18 fully equipped lofts, ideal for short or long stays. Each loft accommodates up to 3 people and has a queen size bed and sofa bed, offering comfort and rest. Enjoy 24/7 reception, digital key access, and high standards of cleanliness and safety. Located on Periférico Sur, opposite the Azteca Stadium, with easy access to hospitals, restaurants and shopping centers.

Top guest favorite
Loft in Ayapango
5.0 out of 5 average rating, 19 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

Guest favorite
Cabin in Tlalmanalco
5.0 out of 5 average rating, 12 reviews

A little house near the volcanoes.

Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.

Top guest favorite
A charming outdoor patio is surrounded by vibrant greenery and a blue-walled house. A round glass table is complemented by six white metal chairs, creating an inviting space for dining or gathering. Potted plants and flowers add color to the serene environment.
Home in Coyoacán
4.97 out of 5 average rating, 108 reviews

Casa Omac | Colonial house with two patios

Typical colonial house, located in the most picturesque and emblematic street of Coyoacán. The style is reminiscent of Frida Kahlo's Blue House, which is a few minutes' walk away. Organized around a large internal patio, the house has 5 double rooms and can host up to 10 people, making it ideal for groups and families.

Guest favorite
An outdoor terrace is presented with a wooden pergola, casting dynamic shadows across a spacious wooden dining table surrounded by benches. A kitchen area is visible with a modern design, and various potted plants are arranged along the perimeter, enhancing the natural ambiance.
Loft in Coyoacán
4.94 out of 5 average rating, 644 reviews

ECO-ROOF with terrace in the heart of Coyoacán

Nice and cozy room with a private balcony in the heart of Coyoacán, one of the most picturesque and traditional neighborhoods in Mexico City. Located a 5-minute walk from downtown Coyoacan, traditional restaurants, cafes, craft bazaars, and museums.

Popular amenities for Santa Cruz vacation rentals