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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
Guest suite in Roma Norte
4.86 out of 5 average rating, 7 reviews

JADE (one)

A retreat inspired by the wabi-sabi philosophy, where beauty is found in imperfection and in the passage of time. In this 1940s house, the original materials have been preserved and showcased, revealing their textures, cracks, and natural imperfections that pay homage to its history. The furnishings are made up of unique pieces from a private collection, which lend character, authenticity, and an intimate atmosphere. A cozy space, ideal for resting, contemplating, and enjoying the tranquility.

Top guest favorite
A cozy seating area is present, featuring a distinctive orange chair and a minimalist white table. Large glass doors offer an unobstructed view of lush greenery and palm trees outside, enhancing the bright and airy ambiance of the space.
Apartment in Condesa
4.99 out of 5 average rating, 124 reviews

Great loft in La Condesa. The best location

Incredible Loft in the best area of La Condesa. Opposite Parque España and steps away from Parque México. A strategic location in Mexico City for walking and eating delicious food. The apartment is bright and very cozy. It has two balconies, a comfortable living room and a dining room for 4, a bar with an open kitchen, a bedroom with a king-size bed and a large TV to watch your series and movies. The kitchen is complete and has everything you need. The sunset is beautiful. You'll love this place!

Guest favorite
A sunlit corner features large floor-to-ceiling windows offering views of greenery outside. A dark wooden table is accompanied by two cushioned seats, while a cozy seating area with a collection of books and decorative items is situated nearby, contributing to a serene environment.
Apartment in Condesa
4.89 out of 5 average rating, 131 reviews

Kaya Kalpa-Organic Designer Apartment in Condesa

After a year-long remodeling project, I’m thrilled to present this personal residence Kaya Kalpa. Every inch of the property has been thoughtfully remodeled. Ideal place for artists, wanderers, all walks of life practitioners to come reset, reflect, and create.  The space is located on Amsterdam street in Condesa, one block from Parque Mexico. You’ll find all nice restaurants, cafes, and stores downstairs. Big supermarket, local Mercado, metro station…all within 5 minutes walking distance.

Top guest favorite
The kitchen area features a wooden dining table surrounded by chairs, with natural light streaming through large windows. A cozy seating area with cushions is visible in the background, complemented by indoor plants. The space is designed for socializing and enjoying meals.
Casa particular in Coyoacán
4.99 out of 5 average rating, 77 reviews

Unique house in Coyoacán

Our house is a unique space, its architecture design is conscious and sensitive to its environment, taking care of the entry of natural light into every corner. Due to its design, each corner tells a story and allows you to create intimate and creative moments without losing contact with the other corners of the house and with the other people who accompany you. On three levels you will find everything you need to rest, to create, to work, to do yoga, to cook, to relax, to read and more!

Guest favorite
The image captures a spacious terrace adorned with various potted plants, leading to a bright bedroom area. Large glass doors open to the patio, allowing natural light to fill the space. A serene landscape and a clear blue sky complement the vibrant greenery.
Loft in Santa María La Ribera
4.96 out of 5 average rating, 341 reviews

Sunny loft with a big terrace in a historic area

New and spacious two stories loft on an award winning renovated building from the 1940´s. Security 24/7 , personal digital code to access the apartment, wifi, fully equipped kitchen, Smart TV with Netflix/Mubi, and a shared laundry room in the building. The loft has one patio in the first floor and a huge terrace full of plants on the second floor next to the bedroom. It is usually very quite but there could be a little noise during the day if another apartment is doing renovations.

Top guest favorite
A welcoming living area is highlighted by wooden flooring and large windows allowing natural light to fill the space. Two armchairs are positioned in front of a coffee table, where a book about mural painting is visible. A fireplace provides a cozy focal point in the background.
Home in Del Carmen
4.95 out of 5 average rating, 388 reviews

José Clemente Orozco House Coyoacán

Located in Coyoacán, typical Mexican neighborhood surrounded by markets, museums and historical buildings, a few blocks from Museu Frida Khalo, this house was the first studio for the painter and muralist José Clemente Orozco, who designed and build it between 1921 and 1923. All the bedrooms have their own bathroom and the main suite has a king-size bed, Smart TV and a terrace. It has a big and beautiful garden and a work space with its own terrace too. The garden is shared by 2 houses.

Top guest favorite
A bright living area features large windows allowing natural light to fill the space. Modern furnishings include a comfortable sofa and armchairs, decorated with soft textiles. A dining table and potted plants are visible, adding a touch of greenery to the open atmosphere.
Apartment in Condesa
4.94 out of 5 average rating, 104 reviews

Stunning PentHouse w/Terrace by Renowned Architect

Enjoy a luxury experience in this exclusive and spacious 110 m² (1184 sq ft) penthouse located in the heart of La Condesa, steps from Ámsterdam Avenue and the emblematic Mexico Park. ✔ King Size Bed ✔ 1 private terrace of 13 m² (140 sq ft) ✔ 1 Balcony ✔ 24 hour surveillance ✔ Art Deco building from 1946 renovated in 2024 You will find yourself in the favorite neighborhood of locals and travelers, recognized for its tree-lined views and its vibrant cultural and gastronomic offer.

Guest favorite
A spacious living area features a high ceiling and exposed brick walls, illuminated by soft lighting. A large mirror hangs above a simple coffee table, surrounded by a cozy sofa and two armchairs. Indoor plants add a touch of nature to the inviting space.
Casa particular in Álvaro Obregón
4.94 out of 5 average rating, 32 reviews

My San Angel Refuge

Mi Refugio San Angel, is a spacious and modern space, to feel out of the city, being centrally in it. It has a Temazcal (under reservation), hydromassage tub, terraces, garden with hammocks, lounge chair, outdoor dining area, bonfire area, indoor fireplace. 2 rooms with full bathroom, queen size sofa bed; open, spacious and fully equipped kitchen. Private parking. The main room can be opened to a view towards the double height of its large room.

Top guest favorite
Loft in Ayapango de Gabriel Ramos M.
5 out of 5 average rating, 19 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

Guest favorite
Cabin in Tlalmanalco de Velázquez
5 out of 5 average rating, 12 reviews

A little house near the volcanoes.

Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.

Guest favorite
A spacious rooftop terrace is highlighted with a covered seating area, featuring a low table and cushioned seating. Lush green plants are dotted around, adding a natural touch. Soft lighting is suspended above, creating an inviting environment. A wooden privacy wall is partially visible in the background.
Home in Xochimilco
5 out of 5 average rating, 11 reviews

Rooftop + SmartHome in Xochimilco-Enjoy Live Relax

Stay in a fully equipped luxury apartment designed for comfort and convenience. Unwind on your private rooftop terrace and enjoy a Smart Home experience. Your stay includes a fully equipped kitchen, washer, high-speed WiFi, and free parking. Ideally located near Xochimilco’s Historic Center, with easy access to public transportation, restaurants, cafés, and the city’s main roads.

Top guest favorite
A charming outdoor patio is surrounded by vibrant greenery and a blue-walled house. A round glass table is complemented by six white metal chairs, creating an inviting space for dining or gathering. Potted plants and flowers add color to the serene environment.
Home in Coyoacán
4.97 out of 5 average rating, 107 reviews

Casa Omac | Colonial house with two patios

Typical colonial house, located in the most picturesque and emblematic street of Coyoacán. The style is reminiscent of Frida Kahlo's Blue House, which is a few minutes' walk away. Organized around a large internal patio, the house has 5 double rooms and can host up to 10 people, making it ideal for groups and families.

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