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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Superhost
Guest suite in Roma Norte
5.0 out of 5 average rating, 3 reviews

JADE (one)

A retreat inspired by the wabi-sabi philosophy, where beauty is found in imperfection and in the passage of time. In this 1940s house, the original materials have been preserved and showcased, revealing their textures, cracks, and natural imperfections that pay homage to its history. The furnishings are made up of unique pieces from a private collection, which lend character, authenticity, and an intimate atmosphere. A cozy space, ideal for resting, contemplating, and enjoying the tranquility.

Guest favorite
A sunlit corner features large floor-to-ceiling windows offering views of greenery outside. A dark wooden table is accompanied by two cushioned seats, while a cozy seating area with a collection of books and decorative items is situated nearby, contributing to a serene environment.
Apartment in Condesa
4.88 out of 5 average rating, 130 reviews

Kaya Kalpa-Organic Designer Apartment in Condesa

After a year-long remodeling project, I’m thrilled to present this personal residence Kaya Kalpa. Every inch of the property has been thoughtfully remodeled. Ideal place for artists, wanderers, all walks of life practitioners to come reset, reflect, and create.  The space is located on Amsterdam street in Condesa, one block from Parque Mexico. You’ll find all nice restaurants, cafes, and stores downstairs. Big supermarket, local Mercado, metro station…all within 5 minutes walking distance.

Guest favorite
A comfortably arranged living area is highlighted by a dark sofa adorned with colorful pillows. A geometric coffee table sits in the center, complemented by a textured rug. Large windows invite natural light and showcase greenery outside, enhancing the connection with nature.
Apartment in Condesa
4.96 out of 5 average rating, 134 reviews

Condesa stylish apt. private terrace 2bdr, 2bd

Fully equipped accommodation, with comfortable and modern furniture and decoration, in one of the best areas of Mexico City "La Condesa" in a closed street with controlled access, and within walking distance of all services and restaurants, cafes, supermarkets. It should be noted that there is a construction project underway three properties away from this building, which is carried out from approximately 8 am to 5 pm from Monday to Friday and on Saturdays from 8 am to 1 pm.

Guest favorite
A spacious living area features a high ceiling and exposed brick walls, illuminated by soft lighting. A large mirror hangs above a simple coffee table, surrounded by a cozy sofa and two armchairs. Indoor plants add a touch of nature to the inviting space.
Casa particular in Álvaro Obregón
4.94 out of 5 average rating, 32 reviews

My San Angel Refuge

Mi Refugio San Angel, is a spacious and modern space, to feel out of the city, being centrally in it. It has a Temazcal (under reservation), hydromassage tub, terraces, garden with hammocks, lounge chair, outdoor dining area, bonfire area, indoor fireplace. 2 rooms with full bathroom, queen size sofa bed; open, spacious and fully equipped kitchen. Private parking. The main room can be opened to a view towards the double height of its large room.

Top guest favorite
Loft in Ayapango
5.0 out of 5 average rating, 19 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

Guest favorite
Guest suite in Coyoacán
4.87 out of 5 average rating, 437 reviews

Casita Suite | WiFi, bath, kitchen | in Coyoacan

Welcome to La Casita, a 450 sq (42 m²) suite that is part of the seven suites in the iconic El Guajolote de Coyoacan. 📍 Just steps away from the Frida Kahlo House and Coyoacán Plaza. 🔐 Private spaces: kitchen, private bathroom, and a cozy sitting area. 🛏️ Queen Size bed. ✍️ Ideal for couples, writers, or nomads. 🌿 Enjoy the tranquility and authenticity of the neighborhood.

Superhost
Apartment in Tláhuac
4.83 out of 5 average rating, 54 reviews

Remodeled apartment, kitchen and garden.

10 Blocks from Metro Line 12 Tlahuac Terminal, Independent apartment with kitchen service, full bathroom, small rest room, dining room with refrigerator, microwave and double bed and a parking space. You can use a nice wood and charcoal grill plus gas grill in the large garden, or just spend the afternoon in the courtyard surrounded by vegetation.

Guest favorite
A spacious sleeping area features a large bed with neutral bedding, flanked by two wooden nightstands. A colorful woven rug adds texture to the floor. A full-length mirror is positioned against the wall, reflecting the room's minimalist design, enhanced by natural light.
Home in Roma Norte
4.89 out of 5 average rating, 159 reviews

New Casa Rosa in the heart of Roma neighborhood

A beautiful and newly remodeled pink house in the heart of Roma neighborhood. A home away from home to spend a few days or a long season near historic sites, shops, and local restaurants in a neighborhood with attitude. All the amenities in a house with personality and impeccable architecture and interior design.

Guest favorite
An outdoor terrace is presented with a wooden pergola, casting dynamic shadows across a spacious wooden dining table surrounded by benches. A kitchen area is visible with a modern design, and various potted plants are arranged along the perimeter, enhancing the natural ambiance.
Loft in Coyoacán
4.94 out of 5 average rating, 643 reviews

ECO-ROOF with terrace in the heart of Coyoacán

Nice and cozy room with a private balcony in the heart of Coyoacán, one of the most picturesque and traditional neighborhoods in Mexico City. Located a 5-minute walk from downtown Coyoacan, traditional restaurants, cafes, craft bazaars, and museums.

Top guest favorite
The exterior of a two-story house is surrounded by lush greenery and vibrant planters. A small terrace features a white umbrella, where a person is seated, enjoying the garden view. A paved pathway leads to the entrance, enhancing the welcoming atmosphere.
Loft in Del Carmen
4.95 out of 5 average rating, 256 reviews

Loft Coyoacan Viveros (Bow)

A super special and very cozy place in the heart of Coyoacán! right next to Coyoacán nurseries, on Melchor Ocampo street Ideal for a couple with or without children who want to enjoy a pleasant stay or a good walk through the wonders of Coyoacán :)

Guest favorite
A spacious sleeping area features a large bed with neutral bedding and a blue throw blanket. Wooden nightstands are placed on either side, while an open shelving unit stands in one corner. Soft lighting enhances the calm atmosphere against the gray walls.
Condo in Iztapalapa
4.93 out of 5 average rating, 536 reviews

HB Flat (2 BR) 15min Airport/10min Estadio GNP

Complete apartment 15 min from the airport, 10 min from the Foro Sol, Palacio de los Deportes and Autodromo Hermanos Rodriguez by car. 2 bedrooms with desk, bathroom, kitchen and living room - dining room.

Top guest favorite
A spacious living area features a light grey sofa adorned with decorative pillows. An intricate glass coffee table sits on a tiled floor, reflecting light from large windows framed by brick arches. Warm curtains complement the vibrant wall art and ceramic plates displayed nearby.
Home in Coyoacán
4.96 out of 5 average rating, 159 reviews

Colonial house with garden in the center of Coyoacán

Luxury colonial house, 350 meters from the center of Coyoacan. The house has a garden and terrace. We strive to make your stay perfect. If your stay is long, we have cleaning service included.

Popular amenities for Santa Cruz vacation rentals

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