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Vacation rentals in Santa Cruz

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Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
A modern studio layout is featured, with a spacious bed adorned with crisp white linens. A wooden kitchenette is visible in the background, while a dining area with a round table and orange chairs is also present. Natural light streams in from a nearby window.
Apartment in Condesa
4.85 out of 5 average rating, 642 reviews

Modern Loft with Balcony & View of Parque Mexico

-Modern, brand new building -Rooftop terrace and brand new gym with views of Parque México and Reforma, -Fully-furnished unit designed for long stays and corporate travel -Free laundry facilities -Housekeeping service: Once a week for reservation of +7 nights Nido Parque Mexico is an incredible architectural accomplishment with the absolute best location in the entirety of Mexico City, on the corner overlooking Parque Mexico, in the heart of la Condesa. With a brutalist facade, ultra-modern in

Top guest favorite
Home in Del Carmen
4.95 out of 5 average rating, 391 reviews

Casa José Clemente Orozco Coyoacán

Located in Coyoacán, typical Mexican neighborhood surrounded by markets, museums and historical buildings, a few blocks from Museu Frida Khalo, this house was the first studio for the painter and muralist José Clemente Orozco, who designed and build it between 1921 and 1923. All the bedrooms have their own bathroom and the main suite has a king-size bed, Smart TV and a terrace. It has a big and beautiful garden and a work space with its own terrace too. The garden is shared by 2 houses.

Guest favorite
Loft in Polanco
4.85 out of 5 average rating, 696 reviews

Kukun Homero Polanco

You’re about to discover your next stay! We’re thrilled to welcome you to our apartments. This building is not only in a prime location, but it also tells a story that celebrates contemporary Mexican art and culture. From handcrafted Talavera pieces made in Puebla to iconic quotes by renowned Mexican creatives like Octavio Paz and Alejandro González Iñárritu, every corner is designed to inspire you. Plus, you’ll get to enjoy one of the best views in the city.

Guest favorite
Casa particular in Álvaro Obregón
4.94 out of 5 average rating, 32 reviews

My San Angel Refuge

Mi Refugio San Angel, is a spacious and modern space, to feel out of the city, being centrally in it. It has a Temazcal (under reservation), hydromassage tub, terraces, garden with hammocks, lounge chair, outdoor dining area, bonfire area, indoor fireplace. 2 rooms with full bathroom, queen size sofa bed; open, spacious and fully equipped kitchen. Private parking. The main room can be opened to a view towards the double height of its large room.

Guest favorite
The building presents a modern design with a prominent use of green glass. The façade is enhanced by colorful window coverings, flanked by two parked cars. A clear sky serves as a backdrop, highlighting the structure's height and the surrounding area.
Apartment in Nezahualcoyotl
4.98 out of 5 average rating, 252 reviews

Safety and Comfort in Edo.MEX

An apartment with great comfort, space, and security. It has a closed circuit, automatic main entrance door, alarm against theft, carbon monoxide and fire, excellent internet quality, and Smart TV. It has a lighting system with 3 shades: White, semi-warm and warm light, suitable for study and rest. The central stairs have handrails, non-slip, and sensor lighting. Fully-equipped kitchen and bathroom. Practical location with amenities available.

Superhost
An open-plan living area features a dining table with black chairs and a contrasting wooden surface. Natural light floods the space through large windows, illuminating a relaxed seating area and green plants. Decorative wall pieces add character to the minimalist design.
Loft in Coyoacán
4.87 out of 5 average rating, 228 reviews

Casa Mavi's loft in Coyoacán

Welcome to Coyoacán! Great 120 m2 loft located just a 5-minute walk from downtown Coyoacán. Experience this quiet and bright open space, ideal for resting or working and decorated with objects full of stories. The loft is located on the third floor of Casa Mavi, an old factory that was remodeled to create a place full of charm that makes it unique. It has shared terraces. With option for a third guest. 200 megabyte Wi-Fi.

Top guest favorite
Loft in Ayapango
5.0 out of 5 average rating, 21 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

Top guest favorite
A charming outdoor patio is surrounded by vibrant greenery and a blue-walled house. A round glass table is complemented by six white metal chairs, creating an inviting space for dining or gathering. Potted plants and flowers add color to the serene environment.
Home in Coyoacán
4.97 out of 5 average rating, 109 reviews

Casa Omac | Colonial house with two patios

Typical colonial house, located in the most picturesque and emblematic street of Coyoacán. The style is reminiscent of Frida Kahlo's Blue House, which is a few minutes' walk away. Organized around a large internal patio, the house has 5 double rooms and can host up to 10 people, making it ideal for groups and families.

Guest favorite
Apartment in Condesa
4.92 out of 5 average rating, 614 reviews

Parkside Residence w/Balcony in Condesa

This suite offers an elegant three-bedroom residence in the heart of Condesa. Enjoy expansive living spaces, private balconies overlooking tree-lined streets, a fully equipped kitchen, and boutique hospitality with daily housekeeping, rooftop access, fitness center, and personalized service.

Guest favorite
A welcoming entrance is displayed with a wooden door featuring decorative glass. Large windows with striped curtains allow natural light to brighten the space. Potted plants line the area, contributing to a serene ambiance. A small decorative item is hung next to the door.
Home in Tláhuac
5.0 out of 5 average rating, 47 reviews

Nice house in the eastern area

Ideal accommodation for small groups, with a quiet and family-friendly atmosphere. Designed for comfortable stays with all the amenities. Close to the Nopalera Metro station, the ISSSTE General Hospital, the Tláhuac General Hospital, the Marista University, and Plaza Las Antenas.

Top guest favorite
Guesthouse in Xochimilco
5.0 out of 5 average rating, 50 reviews

Garden and beautiful house for events and stays

Camino Real Event Garden Disconnect from your concerns in this spacious and serene space. Ideal for all kinds of events, children's parties, meetings, weddings, corporate events, workshops, yoga courses or any other outdoor exercise or activity 🍃🌿🌤️

Guest favorite
An outdoor terrace is presented with a wooden pergola, casting dynamic shadows across a spacious wooden dining table surrounded by benches. A kitchen area is visible with a modern design, and various potted plants are arranged along the perimeter, enhancing the natural ambiance.
Loft in Coyoacán
4.94 out of 5 average rating, 648 reviews

ECO-ROOF with terrace in the heart of Coyoacán

Nice and cozy room with a private balcony in the heart of Coyoacán, one of the most picturesque and traditional neighborhoods in Mexico City. Located a 5-minute walk from downtown Coyoacan, traditional restaurants, cafes, craft bazaars, and museums.

Popular amenities for Santa Cruz vacation rentals