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Vacation rentals in Santa Cruz

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Superhost
Guest suite in Roma Norte
5 out of 5 average rating, 4 reviews

JADE (one)

A retreat inspired by the wabi-sabi philosophy, where beauty is found in imperfection and in the passage of time. In this 1940s house, the original materials have been preserved and showcased, revealing their textures, cracks, and natural imperfections that pay homage to its history. The furnishings are made up of unique pieces from a private collection, which lend character, authenticity, and an intimate atmosphere. A cozy space, ideal for resting, contemplating, and enjoying the tranquility.

Guest favorite
A sunlit corner features large floor-to-ceiling windows offering views of greenery outside. A dark wooden table is accompanied by two cushioned seats, while a cozy seating area with a collection of books and decorative items is situated nearby, contributing to a serene environment.
Apartment in Condesa
4.89 out of 5 average rating, 131 reviews

Kaya Kalpa-Organic Designer Apartment in Condesa

After a year-long remodeling project, I’m thrilled to present this personal residence Kaya Kalpa. Every inch of the property has been thoughtfully remodeled. Ideal place for artists, wanderers, all walks of life practitioners to come reset, reflect, and create.  The space is located on Amsterdam street in Condesa, one block from Parque Mexico. You’ll find all nice restaurants, cafes, and stores downstairs. Big supermarket, local Mercado, metro station…all within 5 minutes walking distance.

Guest favorite
A bright living area features large windows allowing natural light to fill the space. Modern furnishings include a comfortable sofa and armchairs, decorated with soft textiles. A dining table and potted plants are visible, adding a touch of greenery to the open atmosphere.
Apartment in Condesa
4.94 out of 5 average rating, 103 reviews

Stunning PentHouse w/Terrace by Renowned Architect

Enjoy a luxury experience in this exclusive and spacious 110 m² (1184 sq ft) penthouse located in the heart of La Condesa, steps from Ámsterdam Avenue and the emblematic Mexico Park. ✔ King Size Bed ✔ 1 private terrace of 13 m² (140 sq ft) ✔ 1 Balcony ✔ 24 hour surveillance ✔ Art Deco building from 1946 renovated in 2024 You will find yourself in the favorite neighborhood of locals and travelers, recognized for its tree-lined views and its vibrant cultural and gastronomic offer.

Top guest favorite
Condo in Roma Norte
5 out of 5 average rating, 21 reviews

Iconic Roma Norte Duplex • Luxury + Design • A/C

Discover Roma Norte from a signature duplex residence. KAAN Luum was conceived and furnished by an architecture and interior design studio with one clear vision: a high-end experience where design, comfort, and attention to detail live in every corner. Nothing here is generic: from the furniture and lighting to air conditioning, Nespresso and De’Longhi, Sonos sound, and Riedel glassware — everything was chosen to make your stay exclusive, elegant, and memorable.

Guest favorite
A spacious living area features a high ceiling and exposed brick walls, illuminated by soft lighting. A large mirror hangs above a simple coffee table, surrounded by a cozy sofa and two armchairs. Indoor plants add a touch of nature to the inviting space.
Casa particular in Álvaro Obregón
4.94 out of 5 average rating, 32 reviews

My San Angel Refuge

Mi Refugio San Angel, is a spacious and modern space, to feel out of the city, being centrally in it. It has a Temazcal (under reservation), hydromassage tub, terraces, garden with hammocks, lounge chair, outdoor dining area, bonfire area, indoor fireplace. 2 rooms with full bathroom, queen size sofa bed; open, spacious and fully equipped kitchen. Private parking. The main room can be opened to a view towards the double height of its large room.

Superhost
Home in Tlalpan
4.93 out of 5 average rating, 14 reviews

Pedregal Garden House

Beautiful home with a private pool and garden in Fuentes del Pedregal, just minutes from Hospital Ángeles and Artz Pedregal. Ideal for families or groups, with 3 bedrooms, 4 beds, and space for up to 8 guests. The house features 2 full bathrooms, a fully equipped kitchen, dining area, laundry, and parking. Enjoy the patio, lush greenery, and pool in a quiet, private setting with an excellent location in the south of Mexico City.

Top guest favorite
Loft in Ayapango de Gabriel Ramos M.
5 out of 5 average rating, 19 reviews

Beautiful apartment with garden and volcano view

Escape to a dreamy retreat on the volcano route. Perfect for romantic getaways or family gatherings. Enjoy Stunning views of the volcanoes from your private garden, barbecue area and stone oven bring out the chef in you. Spacious and cozy space to relax and enjoy. Located in a picturesque village near Iztapopo National Park, this oasis is the ideal place to disconnect and reconnect with nature and your loved ones.

Guest favorite
Cabin in Tlalmanalco de Velázquez
5 out of 5 average rating, 12 reviews

A little house near the volcanoes.

Village house near the volcanoes Enjoy a unique getaway in our cozy little house, ideal for 2 to 4 people. Perfect for families who want to spend a quiet and cozy weekend. Includes: Bed (King Size) + sofa bed (King Size) Kitchenette Mini fridge Microwave oven TV Wi-Fi Kitchen accessories Experience the local experience with comfort and charm, very close to the volcanoes.

Guest favorite
Guest suite in Coyoacán
4.87 out of 5 average rating, 438 reviews

Casita Suite | WiFi, bath, kitchen | in Coyoacan

Welcome to La Casita, a 450 sq (42 m²) suite that is part of the seven suites in the iconic El Guajolote de Coyoacan. 📍 Just steps away from the Frida Kahlo House and Coyoacán Plaza. 🔐 Private spaces: kitchen, private bathroom, and a cozy sitting area. 🛏️ Queen Size bed. ✍️ Ideal for couples, writers, or nomads. 🌿 Enjoy the tranquility and authenticity of the neighborhood.

Top guest favorite
A charming outdoor patio is surrounded by vibrant greenery and a blue-walled house. A round glass table is complemented by six white metal chairs, creating an inviting space for dining or gathering. Potted plants and flowers add color to the serene environment.
Home in Coyoacán
4.97 out of 5 average rating, 107 reviews

Casa Omac | Colonial house with two patios

Typical colonial house, located in the most picturesque and emblematic street of Coyoacán. The style is reminiscent of Frida Kahlo's Blue House, which is a few minutes' walk away. Organized around a large internal patio, the house has 5 double rooms and can host up to 10 people, making it ideal for groups and families.

Guest favorite
An outdoor terrace is presented with a wooden pergola, casting dynamic shadows across a spacious wooden dining table surrounded by benches. A kitchen area is visible with a modern design, and various potted plants are arranged along the perimeter, enhancing the natural ambiance.
Loft in Coyoacán
4.94 out of 5 average rating, 644 reviews

ECO-ROOF with terrace in the heart of Coyoacán

Nice and cozy room with a private balcony in the heart of Coyoacán, one of the most picturesque and traditional neighborhoods in Mexico City. Located a 5-minute walk from downtown Coyoacan, traditional restaurants, cafes, craft bazaars, and museums.

Top guest favorite
The exterior of a two-story house is surrounded by lush greenery and vibrant planters. A small terrace features a white umbrella, where a person is seated, enjoying the garden view. A paved pathway leads to the entrance, enhancing the welcoming atmosphere.
Loft in Del Carmen
4.95 out of 5 average rating, 256 reviews

Loft Coyoacan Viveros (Bow)

A super special and very cozy place in the heart of Coyoacán! right next to Coyoacán nurseries, on Melchor Ocampo street Ideal for a couple with or without children who want to enjoy a pleasant stay or a good walk through the wonders of Coyoacán :)

Popular amenities for Santa Cruz vacation rentals

  1. Airbnb
  2. Mexico
  3. Santa Cruz