Boutique hotel vacation rentals in Mississippi

Find and book unique boutique hotel rentals on Airbnb

Top-rated boutique hotel rentals in Mississippi

Guests agree: these boutique hotel rentals are highly rated for location, cleanliness, and more.

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Hotel room in Oxford

5 out of 5 average rating, 3 reviews

The Harrisburg Suite Haven by Velvet Ditch Villas

The Harrisburg offers a luxurious & private experience for guests looking to unwind & relax. It provides the necessary amenities for a comfortable stay,while the spacious layout allows for plenty of room to stretch out & make yourself at home! But what truly sets apart is its pool. Take a refreshing dip in the crystal clear waters by the poolside w/a good book & soak up some sun. The tranquil atmosphere of this space makes it the perfect spot to escape from the hustle & bustle of everyday life.

Guest favorite

Hotel room in Vicksburg

4.81 out of 5 average rating, 36 reviews

Tennesse Williams -King Bed Heart of Downtown

Big Room, Big King Bed. Spread out in the Tennessee Williams Room at Halpino. This first floor Room offers a smart TV, seating areas and good closet space on the way to the good size bath with large, tall shower. Close to eating and gathering area. Halpino is close to downtown and the courthouse, a block and a half from Duff Green, the most affordable option in the Duff Green family of properties. You can walk down for breakfast and a tour at Duff or walk downtown for dinner or libation.

Guest favorite

Hotel room in Picayune

4.93 out of 5 average rating, 14 reviews

The Depot Suites Suite 203

Downtown Picayune offers a charming stay at one of our three newly remodeled suites. The festive atmosphere of our downtown life and modern boutiques will please any desire to sit back and relax. Enjoy one of our downtown restaurants and full bars with great music and often live bands. Minutes away from New Orleans or the Mississippi Gulf Coast. Sit outside on the balcony and take in a beautiful sunset. Each suite allows guest to have their own space creating an at home Southern feel.

Guest favorite

Hotel room in Natchez

5 out of 5 average rating, 6 reviews

The Big Muddy Inn-Robert Johnson Suite

Just a stone's throw from the Mississippi River, the Big Muddy Inn is a place to lie down in one of our suites or get down in the Blues Room. The Big Muddy features six art-filled and elegantly designed rooms, a welcoming staff that embodies the definition of Southern hospitality, and a lively Blues Room that plays host to talented musicians and seats up to fifty people. With 6,000 square feet of beautifully renovated elegance, the Big Muddy Inn awaits you in downtown Natchez, Mississippi.

Guest favorite

Hotel room in Laurel

4.91 out of 5 average rating, 44 reviews

The Buzzard's Roost Inn-The New York Room

Room Feature: The New York Room The New York Room features a king bed, a queen-sized pull-out sofa, and an en-suite bathroom, all thoughtfully designed to embody the energy and sophistication of New York City. Guests Enjoy Access To Their own private room and bathroom In-room mini fridge, microwave, and Keurig Smart TV for signing into your favorite streaming apps A shared common area with lounge and kitchenette A guaranteed 24-hour host response time for any questions or assistance

Top guest favorite

Hotel room in Ocean Springs

5 out of 5 average rating, 13 reviews

Best location,pet friendly,huge yard at the Porch

Newly renovated, this warm & inviting 1 bedroom cottage allows a perfect retreat romantic enough for a couple ready to enjoy the night life or walks by the beach & comfortable enough to house three guests looking to experience the parades & other family-friendly entertainment. Located within walking distance to the beach, shopping, dining, festivals & galleries, the suite consists of 1 bedroom, 1 bath, separate living room w/ a futon sofa sleeper, wet bar, and walk-in shower.

Top guest favorite

Hotel room in Ocean Springs

4.98 out of 5 average rating, 177 reviews

Mocking Bird Inn- Magnolia Suite

SOUTHERN CHARM ON THE COAST- The Magnolia Suite at The Mockingbird Inn is nestled on a LIVE OAK lined historic street. You will feel yourself relax as soon as you step in. FORT BAYOU is located next to the property so, take a stroll next door to MARBLE SPRINGS PARK for a view of the bayou and learn the history of the NATURAL SPRINGS that gave Ocean Springs its name. Just 2 blocks to DOWNTOWN OS GALLERIES, SHOPPING & RESTAURANTS , 1 mile to the BEACH, 2 miles to CASINOS

Guest favorite

Hotel room in Natchez

4.94 out of 5 average rating, 242 reviews

The River Walk Inn - Room 801

Spacious upstairs room in a charming 1840's building located on top of the bluff with exquisite views of the MS river. This room has beautiful period furniture, a Keurig, mini fridge, access to a shared balcony, ice machine, washer/dryer, and is within walking distance to all events downtown. Please note that the rooms are above a popular restaurant/bar that frequently offers live entertainment on the weekends.

Guest favorite

Hotel room in Carthage

4.88 out of 5 average rating, 33 reviews

Room 1 (sleep1) Chipley's Squareview Inn & Venue

This newly renovated Boutique Inn combines old-world grandeur from the original 1929 design of the Chipley office building with modern appointments and contemporary amenities. No detail is overlooked in the rustic elegance of this charming space, featuring seven uniquely styled rooms with ensuite marble baths, and all new kitchenettes. Beautiful antiques, cozy comforts and sunlit views grace every private space.

Top guest favorite

Hotel room in Bay St. Louis

4.97 out of 5 average rating, 235 reviews

The Happy Place

Our Happy Place is bright, cheery and very comfortable. Enjoy your morning coffee or a glass of wine in the afternoon overlooking the spacious backyard and bird feeders. Don’t be surprised by a visit from our 2 rescued Terrior pups or either one of the cats as well! 2 block walk to Old Town, and 3 to the Harbor and beaches. Perfect for couples or business travelers. Come see us!

Guest favorite

Hotel room in Laurel

4.89 out of 5 average rating, 133 reviews

Hotel Pinehurst- Central Ave Suite 208

Enjoy easy access to popular shops and restaurants from this charming place . Downtown Laurel is such a beautiful city that's the epitome of southern hospitality. This property is not only classy, but each room tells a story and is named after iconic properties and places. Historic pictures are displayed throughout the property.

Guest favorite

Hotel room in Louisville

5 out of 5 average rating, 20 reviews

The Glover Room

The Glover Room with its original tin ceilings reaching 12 feet, exposed brick walls, and large windows are a true reflection of what used to be. This beautiful room features a queen bed with custom designed headboard, luxurious bedding, dreamy mattress and gorgeous bathroom. This room can also adjoin to The Livingston Room.