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Vacation rentals in Mesopotamia

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Mesopotamia

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A spacious wooden bedroom features a king bed adorned with light bedding, complemented by textured walls and a rustic wood ceiling. A colorful hammock hangs across the room, and natural light filters in through a window, enhancing the cozy ambiance.
Treehouse in Retiro
4.88 out of 5 average rating, 103 reviews

A wooden cabin in the El Retiro Antioquia forest

Imagine sleeping in a wooden cabin in a king-size bed with the lull of the river's sound. When you wake up you will feel like you are in a treehouse overlooking the snowflakes full of birds, going down to the garden with bare feet, having breakfast on the deck and seeing the horizon. During the day, walk, go to the river and the waterfall, get to the stone bathroom and the whirlpool, sit in the hammock, read, and at night light the fireplace (salamander), have a glass of wine at the kitchen counter with your partner, family, and friends.

Guest favorite
A spacious living area showcases high wooden ceilings with exposed beams. Comfortable seating includes two plush sofas and two armchairs arranged around a coffee table. A television is mounted on the wall above a light wooden console. Potted plants add greenery to the setting.
Apartment in la union
5 out of 5 average rating, 11 reviews

Cozy Apartment La Union. (Ant)

Create unforgettable memories in this unique and family-friendly accommodation, with an exceptional location and everything you need to have a comfortable stay in this magical town in eastern Antioquia. This space has been created to offer comfort and tranquility, ideal for travelers and families. The accommodation has a master bedroom and a secondary bedroom with a bunk bed and an extra bed, a private bathroom, a fully equipped kitchen and a living room with a sofa bed, an ideal space to share.

Top guest favorite
A modern cabin is positioned on a hillside, surrounded by lush greenery and offering panoramic views of the surrounding landscape, including a prominent rock formation and a serene body of water in the foreground.
Tiny home in Guatape
4.98 out of 5 average rating, 583 reviews

Foresta: Modern cabin with views of the rock

FORESTA is a modern cabin created with love for you to have an unforgettable stay in the middle of nature, with total comfort. Enjoy the privileged views from the deck, chill out in the jacuzzi, watch the dozens of birds that visit us or have a chat by the fireplace in the living room. FORESTA is a great launchpad to explore Guatape, climb the rock and do kayaking, jet-ski, wakeboard, sailing, paraglading, horseback riding, hiking, getting a helicopter ride or having an ATV tour. You choose!

Guest favorite
Tiny home in Cocorná
5 out of 5 average rating, 6 reviews

Cabin with jacuzzi, private river and natural pool

Enjoy incredible privacy in the beautiful nature of Cocorná. Relax in the jacuzzi or enjoy the beautiful river with a private terrace next to a naturally created pool that belongs exclusively to this property. The cabin features a beautiful bathroom, a king size bed, Wi-fi, a TV with Netflix, and a kitchen equipped with all cooking utensils including a barbecue. We also organize various activities including paragliding and rafting. We offer transportation. Breakfast is included! (to prepare)

Guest favorite
The exterior of a tiny house is illuminated at night, showcasing large windows that reveal warm lighting inside. The structure is set on a hillside, with a covered porch extending from one side, blending harmoniously with the surrounding natural landscape.
Tiny home in Rionegro
4.94 out of 5 average rating, 171 reviews

Amatista (Tiny house) Relax and Remote work

Amethyst, was built in an artisanal way. It is a gift to your soul, a warm experience provided by nature. Enjoy it around a campfire with the delicious steaming taste of a cup of coffee. Is also equipped for the remote work. Our Lane is provided whith many safe routes surrounded by beautiful scenery for walking, jogging, cycling, among other activities. Located 15 minutes from the José María Córdova airport. Close to tourist attractions in Eastern Antioquia.

Top guest favorite
Cabin in Rionegro
4.95 out of 5 average rating, 307 reviews

Cabin 8 min from JMC International Airport

Nature & View just 8 min from JMC Airport Ideal for couples or travelers in transit. Our cabin offers a view of the valley, a quiet atmosphere, self check-in, an equipped kitchen, fast wifi, and all the comforts to relax. For your convenience, there are restaurants with home delivery and inside the accommodation you can buy cold drinks and snacks when you need them. 🚘 Trusted Uber driver Relax, order your favorite food and enjoy the view. Book your date!

Top guest favorite
A single-story house surrounded by lush greenery is showcased. The exterior features a welcoming porch with seating and a hammock. The structure boasts large windows for natural light, while landscaped bushes and trees frame the property, enhancing the serene rural setting.
Farm stay in El Carmen de Viboral
4.97 out of 5 average rating, 104 reviews

☼♥Villa Serena ♥☼ 360° Views-Nature-Serenity

* An incredible house with gorgeous 360° views* * 143 m² / 1539 ft² house size * Private Deck. Views of valley/Rionegro/Airport * Views of mountains * Privacy gate. Alarm. Parking for 5+ Cars * Fully stocked and equipped kitchen * 1 km / 0.6-mile dirt road to the house (any car will access) * There are two homes on the property, the main, larger house is Villa Serena where you will stay, the second home has a separate entrance and is not offered in Airbnb.

Top guest favorite
A covered jacuzzi is visible in the foreground, with bubbling water inviting relaxation. In the background, two hammocks are strung between trees, set against a lush green landscape and a wooden structure that complements the serene setting.
Farm stay in Retiro
4.99 out of 5 average rating, 139 reviews

"Authentic Antioquia Estate with All the Comforts"

Finca Sietecueros - Natural Refuge and Comfort in One Place Escape to Finca Sietecueros, a country house surrounded by forests and mountains. Relax in the jacuzzi, enjoy the hammocks under the trees, or share stories in the campfire area under a starry sky. Ideal for couples, families, and friends seeking peace, nature, and comfort in a unique setting. Book your stay and live an unforgettable experience in contact with nature!

Top guest favorite
The cozy cabin is nestled in a lush green landscape, illuminated by warm outdoor lights. A wooden deck features comfortable seating, overlooking the serene surroundings. Large windows provide a glimpse of the interior, showcasing a warm and inviting space harmonized with nature.
Farm stay in Rionegro
4.96 out of 5 average rating, 290 reviews

Casa del Leñador | Secluded nature retreat

🪓 Retiro Cabin – Casa del Leñador is the house of our dreams. A small, cozy tiny home surrounded by nature. The perfect place to spend a few days as a couple, a family weekend, or work remotely in an environment without distractions. Wake up to birdsong at dawn and enjoy a campfire on the deck at dusk. At Retiro Cabin you will have total independence and an unparalleled view of the countryside in eastern Antioquia.

Superhost
An outdoor terrace is revealed, surrounded by lush greenery and distant mountains. String lights cast a warm glow, illuminating a dining area with wooden tables and chairs. The open layout connects to an indoor space featuring a kitchen visible through large glass doors.
Cabin in Santa Elena
4.92 out of 5 average rating, 107 reviews

Cabaña Roble - A forest retreat

We are located in a native oak forest in the village of El Plan, near Medellin. The 50m2 loft-style cabin that blends with nature on a private 2-block lot. Experience this magical place with fresh air, outdoor fire pits, hiking, and reconnection. Near the cabin you will find a delicious bakery, organic vegetable crops, restaurants, and narrow streets for walking and exploring.

Top guest favorite
An outdoor deck is shown, featuring a spacious jacuzzi surrounded by lush greenery. Sunlight filters through trees in the background, highlighting the serene environment. Two comfortable chairs are positioned nearby, inviting relaxation in the natural setting.
Cottage in Retiro
4.93 out of 5 average rating, 109 reviews

Country house with outdoor hot tub

Beautiful house, with wide and cozy spaces, full of natural light, perfect to get away from technology and the noise of the city, relax in a spectacular outdoor Jacuzzi and then enjoy a night at the fireplace. The sound of the small stream invites you to rest and enjoy nature: bird watching, resting on the grass, feeling the rain and the sun, dreaming under a sky.

Top guest favorite
A wooden cabin exterior features a spacious porch with a rocking chair. The entrance showcases open doors leading into the interior, which is partially visible. Lush greenery surrounds the cabin, enhancing the natural setting of the property.
Cabin in El Carmen de Viboral
5 out of 5 average rating, 19 reviews

Country house / El Carmen de Viboral

Ubicada en una hermosa vereda campesina, esta cabaña en madera cuenta con todo lo necesario para vivir cómodo en la naturaleza: cocina moderna completamente equipada, cama doble, ducha con agua caliente y escritorio con WiFi (90 mbps). Fácil acceso desde Medellín, Marinilla o El Carmen. Parqueadero cubierto disponible.

Popular amenities for Mesopotamia vacation rentals

  1. Airbnb
  2. Colombia
  3. Antioquia
  4. Mesopotamia