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Vacation rentals in Mesopotamia

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Mesopotamia

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
A spacious wooden bedroom features a king bed adorned with light bedding, complemented by textured walls and a rustic wood ceiling. A colorful hammock hangs across the room, and natural light filters in through a window, enhancing the cozy ambiance.
Treehouse in Retiro
4.88 out of 5 average rating, 103 reviews

A wooden cabin in the El Retiro Antioquia forest

Imagine sleeping in a wooden cabin in a king-size bed with the lull of the river's sound. When you wake up you will feel like you are in a treehouse overlooking the snowflakes full of birds, going down to the garden with bare feet, having breakfast on the deck and seeing the horizon. During the day, walk, go to the river and the waterfall, get to the stone bathroom and the whirlpool, sit in the hammock, read, and at night light the fireplace (salamander), have a glass of wine at the kitchen counter with your partner, family, and friends.

Guest favorite
The open-air living space features floor-to-ceiling glass doors that provide panoramic views of the surroundings. A vintage green coffee grinder is positioned prominently within the room. Natural light floods the space, illuminating the wooden beams of the ceiling and the elegant outdoor dining area.
Home in Fredonia
4.92 out of 5 average rating, 26 reviews

Hacienda Naya: The Hidden Coffee Paradise

Hacienda Naya: Where nature meets luxury. A 32-hectare retreat with coffee fields, waterfalls, and breathtaking views. Sleeps up to 13 guests. Relax by the private pool, unwind in total tranquility. Relax in the pool, enjoy a coffee tour, hike to Waterfalls or explore on horseback or ATV. Optional maid (COP 75,000/day) and Colombian cook (COP 120,000/day) for a seamless stay. Just 25 minutes from Fredonia, under two hours from Medellín. Escape, explore, indulge—your perfect getaway awaits.

Guest favorite
A panoramic view captures the surrounding mountains and lush landscapes, with a mix of greenery and water bodies visible below. La Piedra de Peñol is prominently featured on the right, overlooking the expansive reservoir and hills stretching into the distance under a bright blue sky.
Treehouse in El Peñón de Guatapé
4.94 out of 5 average rating, 126 reviews

Treehouse in El Peñol - 360° views of stone

Enjoy the sounds & privacy of nature at this unique cabin in the trees ATOP the closest mountain to Piedra de Peñol. *IMPORTANT NOTES!* Though nicely located in nature, IT'S A TREEHOUSE CABIN IN & ON TOP OF MOUNTAINS, not a resort downtown. *PRICES CHANGE DEPENDING ON NUMBER OF PEOPLE (AB&B's POLICY!) Located as high as La Piedra de Peñol with better views than from the rock as you're able to see it as well! The cabin's isolated away from roads, noises of civilization & surrounded by reserves.

Top guest favorite
A modern cabin is positioned on a hillside, surrounded by lush greenery and offering panoramic views of the surrounding landscape, including a prominent rock formation and a serene body of water in the foreground.
Tiny home in Guatape
4.98 out of 5 average rating, 582 reviews

Foresta: Modern cabin with views of the rock

FORESTA is a modern cabin created with love for you to have an unforgettable stay in the middle of nature, with total comfort. Enjoy the privileged views from the deck, chill out in the jacuzzi, watch the dozens of birds that visit us or have a chat by the fireplace in the living room. FORESTA is a great launchpad to explore Guatape, climb the rock and do kayaking, jet-ski, wakeboard, sailing, paraglading, horseback riding, hiking, getting a helicopter ride or having an ATV tour. You choose!

Guest favorite
Tiny home in Cocorná
5 out of 5 average rating, 6 reviews

Cabin with jacuzzi, private river and natural pool

Enjoy incredible privacy in the beautiful nature of Cocorná. Relax in the jacuzzi or enjoy the beautiful river with a private terrace next to a naturally created pool that belongs exclusively to this property. The cabin features a beautiful bathroom, a king size bed, Wi-fi, a TV with Netflix, and a kitchen equipped with all cooking utensils including a barbecue. We also organize various activities including paragliding and rafting. We offer transportation. Breakfast is included! (to prepare)

Top guest favorite
Cottage in Medellín
4.97 out of 5 average rating, 162 reviews

Cottage and nature in Santa Elena

This little house in the natural reserve San Rafael, is a quiet place with a beautiful landscape, ideal for physical, emotional and spiritual renewal, and finding your harmony in connection with the trees, plants and soil. In the nature reserve you will be able to walk paths between the vegetation and the forest and you will find spaces for observation, contemplation and meditation. It is located very close to the Santa Elena park where you can find restaurants, markets, and crafts.

Guest favorite
Cottage in Cocorná
5 out of 5 average rating, 5 reviews

Cozy country house close to waterfalls and pool

Your own basic & small cabin close to Pailania on 10 acres of paradise, the property features multiple waterfalls, mountain spring water, natural swimming pool, great views over the valley, and lots of green natural space. We have a flower garden, organic food garden, organic food forest. Almost our entire terrain is covered with trees, which is also our goal. We have primary forest but also secondary forest sown by us. We don't offer food! Cascadia Cocorná Register # .187226

Top guest favorite
A contemporary lake house is nestled on the shore, featuring a striking triangular design. Lush greenery surrounds the property, with serene lake waters reflecting the sky. Outdoor decking offers a scenic view, and moored boats add to the tranquil atmosphere of the location.
Island in Guatape
4.98 out of 5 average rating, 116 reviews

Stunning Lake House • Jacuzzi • Amazing Views

Acua Lake House, a private retreat with the best view of La Piedra. Perfect to relax and disconnect in harmony with nature. 🍳 Breakfast included 🛁 Jacuzzi 🌅 Deck 🍖 BBQ 🛀 Bathroom with garden 🛏️ Queen bed + sofa bed, max 4 guests 🌐 Starlink WiFi 🪢 Hammock area 🔥 Firepit 🚣‍♀️ Kayak & paddle board included 🍽️ Room service (optional) 🤵 Concierge by Marco 📍 5 min from La Piedra, 15 from Guatapé ✨ Every detail designed to offer you an unforgettable experience.

Top guest favorite
A single-story house surrounded by lush greenery is showcased. The exterior features a welcoming porch with seating and a hammock. The structure boasts large windows for natural light, while landscaped bushes and trees frame the property, enhancing the serene rural setting.
Farm stay in El Carmen de Viboral
4.97 out of 5 average rating, 104 reviews

☼♥Villa Serena ♥☼ 360° Views-Nature-Serenity

* An incredible house with gorgeous 360° views* * 143 m² / 1539 ft² house size * Private Deck. Views of valley/Rionegro/Airport * Views of mountains * Privacy gate. Alarm. Parking for 5+ Cars * Fully stocked and equipped kitchen * 1 km / 0.6-mile dirt road to the house (any car will access) * There are two homes on the property, the main, larger house is Villa Serena where you will stay, the second home has a separate entrance and is not offered in Airbnb.

Top guest favorite
Cabin in Rionegro
4.95 out of 5 average rating, 307 reviews

Cabin 8 min from JMC International Airport

Nature & View just 8 min from JMC Airport Ideal for couples or travelers in transit. Our cabin offers valley views, a quiet atmosphere, self check-in, a fully equipped kitchen, fast Wi-Fi, and all the comforts to relax. For your convenience, there are restaurants with home delivery and inside the accommodation you can purchase cold drinks and snacks when needed. 🚘 Trusted Uber driver Relax, order your favorite food and enjoy the view. Book your date!

Guest favorite
Cabin in Retiro
4.97 out of 5 average rating, 39 reviews

Camino del Ciprés Boutique Cabin

Camino del Ciprés is a completely private boutique cabin located in a nature reserve in El Retiro, Antioquia. Surrounded by the tranquility of a pine forest, rivers and birdsong. Ideal for rest and connection with nature that you can enjoy with family or friends. Enjoy a warm and cool environment, perfect for contemplating the forest or going hiking. We have hot water, a Jacuzzi, catamaran net, fireplace, kitchen, WiFi, TV, and a terrace for barbecues.

Superhost
Cabin in Retiro
5 out of 5 average rating, 3 reviews

Entreaguas Cabin

Intimate glamping surrounded by forest, accompanied by the constant sound of a stream and birdsong. A wooden A-frame, full of natural light and surrounded by greenery, ideal for slowing down and enjoying without rushing. It has a queen bed, full bathroom, equipped kitchen, cozy living room, private deck and fire area for long nights. A place to toast, chat without a clock, disconnect from the world and wake up in calm, between El Retiro and La Ceja.

Popular amenities for Mesopotamia vacation rentals

  1. Airbnb
  2. Colombia
  3. Antioquia
  4. Mesopotamia