
Vacation rentals in Mesopotamia
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Mesopotamia
Guests agree: these stays are highly rated for location, cleanliness, and more.

A wooden cabin in the El Retiro Antioquia forest
Imagine sleeping in a wooden cabin in a king-size bed with the lull of the river's sound. When you wake up you will feel like you are in a treehouse overlooking the snowflakes full of birds, going down to the garden with bare feet, having breakfast on the deck and seeing the horizon. During the day, walk, go to the river and the waterfall, get to the stone bathroom and the whirlpool, sit in the hammock, read, and at night light the fireplace (salamander), have a glass of wine at the kitchen counter with your partner, family, and friends.

Cozy Apartment La Union. (Ant)
Create unforgettable memories in this unique and family-friendly accommodation, with an exceptional location and everything you need to have a comfortable stay in this magical town in eastern Antioquia. This space has been created to offer comfort and tranquility, ideal for travelers and families. The accommodation has a master bedroom and a secondary bedroom with a bunk bed and an extra bed, a private bathroom, a fully equipped kitchen and a living room with a sofa bed, an ideal space to share.

Foresta: Modern cabin with views of the rock
FORESTA is a modern cabin created with love for you to have an unforgettable stay in the middle of nature, with total comfort. Enjoy the privileged views from the deck, chill out in the jacuzzi, watch the dozens of birds that visit us or have a chat by the fireplace in the living room. FORESTA is a great launchpad to explore Guatape, climb the rock and do kayaking, jet-ski, wakeboard, sailing, paraglading, horseback riding, hiking, getting a helicopter ride or having an ATV tour. You choose!

Cabin with jacuzzi, private river and natural pool
Enjoy incredible privacy in the beautiful nature of Cocorná. Relax in the jacuzzi or enjoy the beautiful river with a private terrace next to a naturally created pool that belongs exclusively to this property. The cabin features a beautiful bathroom, a king size bed, Wi-fi, a TV with Netflix, and a kitchen equipped with all cooking utensils including a barbecue. We also organize various activities including paragliding and rafting. We offer transportation. Breakfast is included! (to prepare)

Cabin 8 min from JMC International Airport
Nature & View just 8 min from JMC Airport Ideal for couples or travelers in transit. Our cabin offers a view of the valley, a quiet atmosphere, self check-in, an equipped kitchen, fast wifi, and all the comforts to relax. For your convenience, there are restaurants with home delivery and inside the accommodation you can buy cold drinks and snacks when you need them. 🚘 Trusted Uber driver Relax, order your favorite food and enjoy the view. Book your date!

Casi Cielo! Heaven's Edge
Nestled 7,000 feet high, our tranquil cabin promises breathtaking mountain and waterfall vistas. This retreat, perfect for romantic getaways or family escapades, enchants with its warming fire pit and rejuvenating hot tub. Experience the stunning wilderness, bask in the magnificent scenery, and craft unforgettable memories. This is not just a stay, but an experience enveloped in serene beauty, embracing the extraordinary amidst the ordinary. (500 characters)

☼♥Villa Serena ♥☼ 360° Views-Nature-Serenity
* An incredible house with gorgeous 360° views* * 143 m² / 1539 ft² house size * Private Deck. Views of valley/Rionegro/Airport * Views of mountains * Privacy gate. Alarm. Parking for 5+ Cars * Fully stocked and equipped kitchen * 1 km / 0.6-mile dirt road to the house (any car will access) * There are two homes on the property, the main, larger house is Villa Serena where you will stay, the second home has a separate entrance and is not offered in Airbnb.

Country house, excellent location, beautiful view!
We invite you to enjoy a beautiful space surrounded by nature, with all the comforts so you can relax and unwind. You will feel like you are at home. Ideal place for teleworking (digital nomads) and long stays. Just 10 minutes from La Ceja, 45 minutes from the international airport, and 1 hour from Medellín. Pets are welcome. We also offer Yoga classes and Ayurvedic therapies (Abhyanga/Swedana). Perfect place for "slow" tourism!

Casa del Leñador | Secluded nature retreat
🪓 Retiro Cabin – Casa del Leñador is the house of our dreams. A small, cozy tiny home surrounded by nature. The perfect place to spend a few days as a couple, a family weekend, or work remotely in an environment without distractions. Wake up to birdsong at dawn and enjoy a campfire on the deck at dusk. At Retiro Cabin you will have total independence and an unparalleled view of the countryside in eastern Antioquia.

Loft apartment, with an excellent location.
Disfruta la comodidad y tranquilidad en el corazón de La Ceja Relájate en este alojamiento céntrico y acogedor con una gran vista. A solo dos cuadras del parque principal y muy cerca de restaurantes, tiendas, bancos, el centro comercial VIVA La Ceja, cine y gimnasio. Descubre La Ceja: un lugar tranquilo, rodeado de aire puro y con la calidez de su gente, perfecto para descansar y recargar energía.

Mountain retreat: sounds of silence # 1
Discover tranquility in this cozy retreat surrounded by nature. Our cabin, built in wood and with a modern and warm design, offers a perfect space to rest, read, contemplate the landscape or simply enjoy the silence. From its terrace or large windows you can admire endless mountains, golden sunsets and clear skies that invite calm. Inside you will find a comfortable and well-equipped atmosphere.

Comfortable studio apartment in Rionegro
Comfortable, fully-equipped studio apartment located in downtown Rionegro, in the Tres Cantos residential area, a quiet place for your rest and comfort, just a 10-minute walk from the town's main park, 5 minutes from the San Nicolás shopping center, and 20 minutes from José Maria Cordoba International Airport. Nearby are bus stops, supermarkets, shops, shopping malls, and restaurants.
Popular amenities for Mesopotamia vacation rentals
Other great vacation rentals in Mesopotamia

Amazing house near Medellín

Minimalist Tiny House in Nature, El Retiro

Cabin with Mountain View - Moka

Beautiful cabin with lakes and 24-hour doorman

En Calma la Vista es garantizada

Villa Paraíso Natural: Peace, River, and Waterfalls

Romantic cabin with Jacuzzi| 8 min JMC

Llanogrande Lake Cabin w/ Hot Tub, BBQ & Cinema
Destinations to explore
- Medellín Vacation rentals
- Bogotá Vacation rentals
- Medellín River Vacation rentals
- Medellin Metropolitan Area Vacation rentals
- Oriente Vacation rentals
- Cali Vacation rentals
- Pereira Vacation rentals
- Bucaramanga Vacation rentals
- Guatapé Vacation rentals
- Envigado Vacation rentals
- Melgar Vacation rentals
- Ibagué Vacation rentals
- Lleras Park
- Atanasio Girardot Stadium
- Parque El Poblado
- Santafé
- Energy Living
- Parque Explora
- Parque de los Pies Descalzos
- Guatapé
- Parque de Belén
- Plaza Mayor
- Plaza Botero
- Oviedo
- Unicentro Medellín
- Parque Sabaneta
- Los Molinos Shopping Center
- Museo de Antioquia
- Prado Centro
- Parque San Antonio de Pereira
- Parque Arvi
- Wajaca Cc. Mayorca Mega Plaza
- Parque de Bostón
- Museo Pablo Escobar
- San Diego Mall
- Premium Plaza




