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Vacation rentals in Mesopotamia

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Mesopotamia

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
Tiny home in Guatape
4.98 out of 5 average rating, 643 reviews

Foresta: Modern cabin overlooking the Rock

FORESTA is a modern cabin created with love for you to have an unforgettable stay in the middle of nature, with total comfort. Enjoy the privileged views from the deck, chill out in the jacuzzi, watch the dozens of birds that visit us, or have a chat by the fireplace in the living room. FORESTA is a great launchpad to explore Guatape, climb the Rock and do kayaking, jet-skiing, wakeboarding, sailing, paraglading, horseback riding, hiking, helicopter tours or ATV rides. You choose!

Top guest favorite
Cabin in Sabaneta
4.94 out of 5 average rating, 145 reviews

eDeensabaneta Ibiza cabin

Este alojamiento único tiene personalidad propia. Disfruta de unas vistas increíbles en la terraza mientras te relajas en el jacuzzi, o disfruta de la acogedora cabaña en una zona muy próxima a sabaneta con la atención que tú te mereces. Esta cabaña hace parte de un sueño familiar llamado eDeen, donde nuestra prioridad es que cada momento sea único, brindando la mejor atención de manera personalizada para que los huéspedes se sienta como en casa.

Top guest favorite
Cabin in Santa Elena
4.99 out of 5 average rating, 181 reviews

Lake Chalet | Private Jacuzzi + Nature

🌿 Lake Chalet – Santa Elena Escape to a natural retreat with a private lake, large windows, and a peaceful setting. With very complete equipment and distribution. Just 10 minutes from the main park, enjoy the birdsong, the sound of water and the cool climate of the Antioquia countryside. Ideal for couples, families or a relaxing getaway. Nature, tranquility, and unforgettable moments in one place. 💛✨ ✅ We are pet friendly🐶🐈

Top guest favorite
Cabin in Rionegro
4.98 out of 5 average rating, 110 reviews

Nature & View | Cabin with Jacuzzi and Nature

Enjoy an unforgettable experience in our private cabin, located just 8 minutes from José María Córdova International Airport. Enjoy a panoramic view of the city and relax in your private Jacuzzi. The cabin is equipped with a full kitchen, fast wifi, workspace and self check-in. You will find several nearby restaurants with home delivery, and inside the accommodation we have drinks and snacks to buy. 🚘 Trusted Uber driver

Top guest favorite
Chalet in Antioquia
4.96 out of 5 average rating, 333 reviews

Cabin with Jacuzzi 8 min from JMC Airport

Welcome to Quimera Ecolodge, a charming chalet located in a natural paradise paradise just 10 minutes from José María Córdova Airport. At Quimera Ecolodge, every corner has been designed to offer you a unique experience, combining comfort, sustainability, and an authentic connection with the natural environment, ideal for those who want to escape the hustle and bustle of the city without losing proximity to comfort.

Guest favorite
Cabin in El Peñol
4.95 out of 5 average rating, 144 reviews

Sun Palm Cabin: Nature and Comfort in El Peñol!

Discover an exceptional retreat surrounded by nature, where every detail is designed to offer you an unforgettable experience. This cabin combines elegance and comfort. Relax in your private jacuzzi while enjoying breathtaking panoramic views in a serene environment. Perfect for a romantic getaway or rejuvenating vacation, you will find the ideal harmony between privacy and natural beauty. Your perfect escape awaits!

Guest favorite
The cozy cabin is nestled in a lush green landscape, illuminated by warm outdoor lights. A wooden deck features comfortable seating, overlooking the serene surroundings. Large windows provide a glimpse of the interior, showcasing a warm and inviting space harmonized with nature.
Farm stay in Rionegro
4.95 out of 5 average rating, 301 reviews

Lumberjack's House | Secluded nature retreat

🪓 Retiro Cabin – Casa del Leñador is the house of our dreams. A small, cozy tiny home surrounded by nature. The perfect place to spend a few days as a couple, a family weekend, or work remotely in an environment without distractions. Wake up to birdsong at dawn and enjoy a campfire on the deck at dusk. At Retiro Cabin you will have total independence and an unparalleled view of the countryside in eastern Antioquia.

Top guest favorite
The exterior of the villa showcases a white and brick facade under a partly cloudy sky. Lush greenery surrounds the property, and a gravel path leads to the entrance. A scenic view of the lake is visible in the background, contributing to the serene atmosphere.
Villa in Peñol
4.98 out of 5 average rating, 106 reviews

Incredible Villa, Peñol-Guatapé with lake views

La Villa de Teo is a beautiful place located in Peñol-Guatape, ideal for enjoying nature with spectacular views of the lake. We have outdoor spaces to enjoy a family BBQ and with all the necessary equipment to make your stay very quiet and comfortable. We are located very close to tourist attractions. La Piedra del Peñol, La Piedra del Marial, La Réplica del Peñol and Guatapé. Access to the farm is on a paved road.

Top guest favorite
Farm stay in El Carmen de Viboral
4.97 out of 5 average rating, 106 reviews

☼♥Villa Serena ♥☼ 360° Views-Nature-Serenity

* An incredible house with gorgeous 360° views* * Private Deck. Views of valley/Airport * Mountain views * Privacy gate. Alarm. Parking for 2 Cars * Fully stocked and equipped kitchen * 1 km / 0.6-mile dirt road to the house (any car will access) * There are two homes on the property, the main, larger house is Villa Serena where you will stay, the second home has a separate entrance and is not offered in Airbnb.

Top guest favorite
A floating house showcases a thatched roof illuminated in warm tones, situated on a wooden deck. Two sun loungers are positioned beside a tranquil waterway, with a kayak resting nearby. Lush greenery outlines the serene landscape under a twilight sky.
Houseboat in Peñol
4.99 out of 5 average rating, 136 reviews

Floating House-Jacuzzi-WIFI-Kayak-El Peñol

Lakeside Paradise – Floating House with Jacuzzi, Kayak and Mountain Views Immerse yourself in the serenity of the KAUBA house on the water. Located in the lake of El Peñol. A private floating dream escape that combines the tranquility of the water with comfort. It is an oasis of relaxation, surrounded by stunning landscapes that will make you feel in harmony with nature.

Guest favorite
An outdoor deck is showcased with a spacious jacuzzi, surrounded by lush greenery and native plants. Comfortable seating arrangements are positioned nearby, providing a welcoming space for relaxation. The scene is illuminated by warm sunlight filtering through the trees, enhancing the tranquil atmosphere.
Cottage in Retiro
4.91 out of 5 average rating, 116 reviews

Country house with outdoor hot tub

Beautiful house, with wide and cozy spaces, full of natural light, perfect to get away from technology and the noise of the city, relax in a spectacular outdoor Jacuzzi and then enjoy a night at the fireplace. The sound of the small stream invites you to rest and enjoy nature: bird watching, resting on the grass, feeling the rain and the sun, dreaming under a sky.

Top guest favorite
A charming casita is nestled among trees, featuring a deck with glass walls that invites natural light. Surrounded by lush greenery, the structure stands elevated on stilts, blending harmoniously into its tranquil environment.
Cabin in La Ceja
4.98 out of 5 average rating, 107 reviews

La casita de las alas

Nuestra casita es un espacio único donde no solo encuentras desconexión del mundo exterior sino que te conectas con tu mundo interior. Simplemente, es un espacio mágico lleno de paz y de naturaleza.

Popular amenities for Mesopotamia vacation rentals

  1. Airbnb
  2. Colombia
  3. Antioquia
  4. Mesopotamia