
Vacation rentals in Isthmus of Panama
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Top-rated vacation rentals in Isthmus of Panama
Guests agree: these stays are highly rated for location, cleanliness, and more.

Puntita Manzanillo, fantastic sea and jungle
Come visit one of the most unique and exclusive properties in the Panamanian Caribbean. A magical completely private 5 acre property nestled between the Caribbean Sea (500meters of ocean front) and the jungle. Surrounded by a garden of corals and visited by monkeys and macaws. Our energy is solar and we have our own aqueduct. Temperature oscillates between 72 and 84 degrees F. It is rented in its entirety. It has 3 one bedroom cabins with full baths. Satellite Internet (Starlink) is provided.
4.97 out of 5 average rating, 115 reviews
Hot Tub in the Clouds | Luxury Mountain Escape
Looking for the ultimate luxury mountain retreat? Located in one of the highest areas of Altos del María, this stylish and modern home is a feast for the eyes. Relax in the hot tub, unwind in the hammock, and take in lush mountain views surrounded by clouds. Enjoy cool mountain air, tranquility, and complete privacy. Whether you want to simply relax and enjoy the home, or get out and explore, there are plenty of activities and amenities throughout Altos del María to make your stay unforgettable.
5.0 out of 5 average rating, 3 reviews
Beach House-Amazing Pool & Jacuzzi - Pet Friendly
Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with Smart Home Energy Management Systems.
4.98 out of 5 average rating, 222 reviews
Club House facing the lake with dock, jacuzzi and BBQ
Wake up by the lake in Cerro Azul, where nature and design come together in perfect harmony. This modern house offers 4 bedrooms with private bathrooms and 2 guest bathrooms, making it ideal for special celebrations, intimate weddings, or unforgettable gatherings with family and friends. Its open-plan, industrial-style kitchen is complemented by spacious areas and a terrace that blends into the landscape. The master suite, featuring a Jacuzzi, invites you to unwind and reconnect with yourself.
5.0 out of 5 average rating, 6 reviews
CasAna
Fantastic place with open spaces, natural light and fresh air, 2 bedrooms with internal bathroom, terrace to receive the sunrise and sunset, private pool that makes you feel like you are flying, while you can share with friends and family in a group area provided by a spacious deck, enjoy your barbecues on the terrace and kitchen equipped with everything you need Located 10 meters from Playa La Ermita and 12 meters from the entrance to the Valley, and a hop from the Los Camisones Restaurant.
4.98 out of 5 average rating, 41 reviews
Modern House with Great Views and Heated Pool
Modern mountain house in Altos del Maria, Panama, a gated comunity at just 1 hour and 30 minutes away from Panama city. The comunity has rivers, bird watching trails, and is only 25 minutes away from the pacific beaches. Its a perfect place to take a break and relax. The house has a modern decor, infinity pool, 2 bedrooms with A/C, wifi, dishwashing machine, washer and dryer and great view of the mountains. Free late checkout is given for rentals checking out on Sundays.
4.82 out of 5 average rating, 337 reviews
El Palmar, beach 50 meters away
Listen to the waves from the privacy of our terrace and create unforgettable memories in this unique and family-friendly accommodation just steps from the beach with a private pool. El Palmar is a quiet community with several restaurants available a few steps from the house. The property is fully fenced for the tranquility and safety of children and their pets. In addition, you have wifi, cable TV in both rooms and air conditioning in the dining room and in all the bedrooms
4.89 out of 5 average rating, 184 reviews
Casamar | Large terrace and garden overlooking the ocean
First floor apartment, large terrace and private garden overlooking the ocean, designed with multiple spaces to relax and share. Each bedroom has its own terrace, plus several outdoor environments in the garden. From the property you can directly access one of the pools of the complex and is located a short walk from the sea and the beach club, ideal for enjoying the Casamar experience to the fullest. Resort with water park, swimming pools, and beach club with ocean access.
4.94 out of 5 average rating, 32 reviews
Mountain retreat
Our beautiful, modern, comfortable house is designed in an eco-friendly manner in harmony with nature. It is an ideal place to relax and also a base to explore the area which is in a beautiful part of Panama near a cloud forest national park with amazing hiking to waterfalls and local communities. The house is large, sleeping 12, within 17 acres of forest with rivers for swimming. We can arrange tours and hosted retreats for yoga, cooking and more.
4.92 out of 5 average rating, 196 reviews
Stunning loft in Buenaventura Golf&Beach Resort
Stunning Remodeled Loft in The Buenaventura Golf & Beach Resort, Panama. Nestled within the lush offerings of Buenaventura Beach Resort in Panama, this completely remodeled loft presents a harmonious blend of modern luxury and natural beauty, creating a truly stunning living space. The loft features an open-concept design that maximizes light and airiness. The high ceilings lend an expansive feel, making the space both inviting and luxurious.
5.0 out of 5 average rating, 45 reviews
Beachfront Loft in Farallón
Wake up to the ocean in this beautiful beachfront loft in Farallón, located in the exclusive Miramar Loft next to the Decameron Hotel. Relax on the balcony with sea views, enjoy the pool, and walk to the beach with private cabanas on the sand. The apartment offers 2 bedrooms, a full kitchen, A/C throughout, and fast Wi-Fi. Just 2 hours from Panama City. Book now and live the beach experience you deserve!
4.98 out of 5 average rating, 87 reviews
Blue Sky Lodge; the best view in Altos del María
This luxury mountain cabin offers a modern design, quality finishes, and 180° panoramic views of mountains and sea. It is located in a secure gated community, surrounded by a green garden, with large glass windows that favor connection with nature. The climate is pleasant, with temperatures between 23°C and 28°C. .
4.94 out of 5 average rating, 68 reviewsPopular amenities for Isthmus of Panama vacation rentals
Other great vacation rentals in Isthmus of Panama

Luxury Beachfront Home • Private Pool • Coronado
4.89 out of 5 average rating, 18 reviews
Casa De Ola, Jungle Beach Cabin
4.96 out of 5 average rating, 89 reviews
Casa Condal - Your Luxury Retreat in Cerro Azul
5.0 out of 5 average rating, 28 reviews
A peaceful retreat in the countryside
4.95 out of 5 average rating, 61 reviews
Spectacular Beachfront House
5.0 out of 5 average rating, 42 reviews
Buenaventura home directly on beach, private pool
4.97 out of 5 average rating, 60 reviews
Luxury Oceanfront Villa | Pool Sunset views | 5 Br
4.64 out of 5 average rating, 171 reviews
Jungle Sky Loft | Mountain & Ocean Views
4.94 out of 5 average rating, 32 reviews




