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Vacation rentals in Isthmus of Panama

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Top-rated vacation rentals in Isthmus of Panama

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
The living area features large glass doors that invite natural light and views of the garden. Indoor plants enhance the space, and a cozy seating arrangement includes a sofa and eclectic chairs. A workspace with a desk and lamp is positioned to the side.
Guesthouse in El Valle de Antón
4.99 out of 5 average rating, 104 reviews

Spacious Casita with Bamboo View

Walk 20 minutes to the artisan mercado and restaurants on Ruta 71. Cerro Cara Iguana trailhead is walking distance from the casita. High insulated ceilings and 2 ceiling fans for comfort. Private hammock patio for an afternoon nap. Washer/dryer in the casita. Hot water throughout. Kitchen has a 2 burner cooktop, countertop oven, microwave, instant pot, electric skillet, blender and coffee maker. 2 Internet providers and a small workspace available. * No television set * Non smoking property

Top guest favorite
A modern living area features a light-colored sofa adorned with colorful cushions. A round coffee table sits on a textured rug, while a dining table for six is visible in the background. Large windows present striking views of the city skyline.
Apartment in Panama City
5 out of 5 average rating, 38 reviews

Luxury apt in Panama City 2 Rooms 3 Baths

El edificio Wanders by yoo esta ubicado en el corazón de la ciudad, es un proyecto fuera de serie donde cada rincón tiene una historia que contar. Recepción 24/7, muchas areas de esparcimiento, estación de hidratación. En las afueras del lobby tenemos la Cafetería cafe con teclas y un restaurante de Carnes Popino. En el area social servicio de barra en la piscinas, parque de niños, sala de juegos con pantallas en e l techo baños, salon de eventos, cocina para eventos, gym full equipado y más

Guest favorite
A well-appointed living area is showcased with a light sofa and decorative pillows, arranged on a patterned rug. Expansive floor-to-ceiling windows allow natural light to illuminate the space, offering views of the city. A coffee table and stylish floor lamp complement the inviting atmosphere.
Apartment in Panama City
5 out of 5 average rating, 15 reviews

Luxury 2BR w/Ocean Views – 27th Fl, Wanders YOO

The name of the Complex comes from the world-renowned architect and interior designer, Marcel Wanders. He had the idea to accentuate the flora and fauna of Panama and bring a relaxed sensation even though the complex is located in the middle of the city. This unit in particular has the most detailed pick on designer furniture from brands such as Herman Miller and Restoration Hardware. The kitchen is also fully equipped with Thermador appliances so you can live the Wanders & Yoo experience.

Top guest favorite
An aerial view of the property showcases a spacious layout surrounded by lush greenery. A large saltwater pool and a hot tub are visible alongside a well-maintained outdoor area with red umbrellas providing shade. The roof of the main structure features a brown tone, blending with the natural surroundings.
Home in Costa Esmeralda
4.98 out of 5 average rating, 180 reviews

Beach House-Amazing Pool, Surf & Pet Friendly

Majestic Sands! Come relax with the whole family at this piece of paradise.located in a private beach community in Costa Esmeralda, San Carlos. Few minutes from the Pan-American highway and a few minutes from other local beaches such as Gorgona, and Coronado. It is a 5-minute walk to our beach, or if you prefer you can go by car. The home includes an amazing saltwater pool and hot tub with hammocks with views of amazing palm trees.Uninterruptible power with solar and battery backup systems.

Guest favorite
A balcony is featured with two stylish chairs and a small side table. Lush treetops are visible below, with a vibrant urban skyline in the background. Natural light illuminates the space, creating a serene outdoor setting for relaxation.
Apartment in Panamá
5 out of 5 average rating, 10 reviews

Cozy 1BR•Balcony Gym Rooftop Pool•Near Multiplaza

➤ Charming apartment, warmly decorated, balcony with enchanting views of lush treetops with the city's vibrant skyline in the distance. Minutes away from Multiplaza Mall . ★ Perfect for Remote Workers, 500 MB speed internet. ★ Walk 5-10 mins to Restaurants, Supermarkets, Multiplaza Mall, Cafes & Shopping ➤ Urban Escape - Building Highlights: ★ Gym ★ 2 Co-Working Spaces ★ Pool on the Rooftop Terrace ➤ Located in San Francisco: Explore the City Easily | Uber-Friendly

Top guest favorite
A private cabin features a cozy sleeping area with a spacious bed adorned with colorful bedding and red accent pillows. Natural light streams through mesh and fabric panels, offering views of the surrounding mangroves and waterfront. A hammock is positioned nearby for relaxation.
Hut in Isla Cristóbal
4.91 out of 5 average rating, 176 reviews

Cocovivo Snoozy Sloth

Private waterfront cabin with one luxurious king-sized bed and dock with spectacular views of our coral-filled bay. When night falls, sparkling bioluminescent waters makes this cabin seem like it's out of a fairy tale. A flourishing coral reef aligns the whole property for snorkeling, kayak or SUP expeditions! Did I mention we have a shipwreck too? "Jetsons-meet-Flintstones" is the vibe here. Please read the “Other things to note” section so you know what to expect!

Superhost
An inviting outdoor pool area is surrounded by lush greenery and vibrant flowers. Comfortable lounge chairs are positioned nearby. The expansive view captures a tranquil lake and well-maintained landscaping under a bright sky, providing a serene outdoor retreat.
Home in Rio Hato
5 out of 5 average rating, 4 reviews

Private Pool/Buenaventura/Beach access/750MB

Spacious house located in Buenaventura. This high-end location features: - A Marina where you can load and unload your water toys! (at an extra cost) - Amazing restaurants where you can enjoy different flavors from around the world. - A fully stocked wine store where you will find a varied selection, as well as charcuterie and a excellent bread. - There are yoga and pilates classes - Social areas and beach access - A 19-hole golf course. - An amazing coffee store.

Guest favorite
A spacious living area features a combination of modern and vintage furnishings. A large turquoise sofa and a floral chaise lounge are complemented by a round coffee table and a green wooden chair. Exposed stone walls and large windows with blue accents create a warm ambiance.
Apartment in Panamá
4.98 out of 5 average rating, 148 reviews

Escape to the Heart of Casco with a Private Balcony

Location is everything – just steps away from the city’s best restaurants, bars, stunning churches, and fascinating museums. Explore the historic district on foot while enjoying the comfort of a stylish apartment featuring: • A spectacular balcony with beautiful views • A fully equipped kitchen • 1.5 bathrooms • Cozy beds that make you feel right at home • Surrounded by iconic calicanto stone walls that reflect the charm of Panama’s colonial past.

Top guest favorite
A modern living area is furnished with a dark sectional sofa adorned with colorful cushions. A coffee table rests on a patterned rug, and large windows provide a view of the ocean, allowing natural light to fill the space.
Apartment in Panamá
4.93 out of 5 average rating, 58 reviews

Elegance and Comfort with a Panoramic Ocean View

Experience the luxurious oceanfront PH Yoo experience in this stylish apartment with king bed and floor-to-ceiling windows. Enjoy top-notch amenities: a swimming pool, gym, squash court, spa, and more. Prime location, close to tourist areas, restaurants, bars, and malls. Inside the building you can find gastronomic options with exclusive discounts and free valet parking. A modern, spacious and sophisticated space, ideal for an unforgettable getaway.

Top guest favorite
An infinity pool blends seamlessly into the ocean view, with a person standing at the edge. A lounge chair is positioned nearby, providing a relaxing spot to enjoy the scenery under a clear blue sky.
Condo in San Carlos
4.96 out of 5 average rating, 132 reviews

New ocean apartment in beautiful beach complex

Modern new condo with breath taking views of the Pacific Ocean. We are in a beautiful new beach complex, Punta Caelo, with direct beach access, a beach club, and several large swimming pools. The Social Area is resort quality with deck chairs, infinity pools, billiards, children’s pools and pool beds. The apartment is open and spacious with a fully stocked kitchen and large terrace directly looking out over the ocean.

Guest favorite
Apartment in Nueva Gorgona
5 out of 5 average rating, 16 reviews

Top Floor Beachfront Bliss Royal Palm- Views!

This total beachfront, top floor unit is exquisitely decorated and unique from every apartment in the building. Check out that marine blue kitchen! Enjoy watching Panama's spectacular sunsets from this amazing balcony. The kitchen is fully stocked with high-end appliances and ready for you to make your favorite meal. Or, walk a few minutes up the beach to a fonda for the fresh catch of the day!

Guest favorite
A tranquil swimming pool is featured, surrounded by stone and wooden decking. Lounge chairs are positioned nearby, with a clear view of the ocean in the background. A pergola provides shaded seating, complementing the serene coastal environment.
Apartment in San Carlos
4.94 out of 5 average rating, 124 reviews

3 bedroom apartment by the beach at Punta Caelo

Hermoso apartamento completamente nuevo y equipado en Punta Caelo, perfecto para disfrutar de la playa en escapadas de fin de semana o estadías largas en el exclusivo condominio de Punta Caelo. Beautiful beach apartment in Punta Caelo, perfect for enjoying the beach on a weekend get away or longer stays. This brand new apartment is located in the exclusive Punta Caelo development.

Popular amenities for Isthmus of Panama vacation rentals