Vacation rentals in Isola

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Top-rated vacation rentals in Isola

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Top guest favorite
The exterior showcases a single-story house with a brick facade and a blue metal roof. Lush greenery and flowering plants are arranged along the front, complementing the palm tree near the entrance. A driveway leads up to an overhang and parked vehicle, with a lawn stretching across the front.
Home in Leland
4.98 out of 5 average rating, 150 reviews

“Pink on the Creek”Guest House

WE HAVE BREAKFAST, SNACKS, AND ICE CREAM FOR YOU THERE. NO CLEANING FEE ! ! VERY SAFE AREA IN THE HEART OF THE MISSISSIPPI DELTA WHERE THE BLUES WAS BORN! Extra charge per person per night after 6 Max is 8. Better than just a motel room. A bit of antique & modern, though greatly cared for, shows age in some places, loving wear, quaint aging & charming patina both inside and outside, is super clean/sanitized. people love it. Very Affordable for a whole house in this area. A selection of pillows.

Top guest favorite
Guesthouse in Drew
5 out of 5 average rating, 26 reviews

Cozy Country Pool House Retreat

Our cozy pool house retreat is located in the Heart of the Mississippi Delta on a secluded 40 acre country setting surrounded by woods and a beautiful bayou full of cypress trees. It's located just off Drew-Merigold Road away from everyone, with no neighbors!! Yet close to everything - only 5 minutes to Drew, 10 minutes to Ruleville, 15 minutes to Cleveland, and 30 minutes to Clarksdale. We are only 10 minutes to McCarty's Pottery in Merigold, and 15 minutes to Peter's Pottery In Mound Bayou.

Top guest favorite
An outdoor bar area constructed from natural wood features several stools and a countertop. The setting is surrounded by greenery, with trees providing shade. Decor elements like hanging plants and rustic ornaments are present, contributing to a relaxed, natural environment.
Cabin in Yazoo County
4.91 out of 5 average rating, 148 reviews

“Paradise”

This beautiful, cozy, secluded, 2 bed/2 bath home gives you the feeling of being in the mountains! It features a fully equipped kitchen, plunge pool, hot tub, 2 outdoor bars, cooking area with a charcoal grill. It is surrounded by over 2,000 sq ft. of outdoor deck!! This property also has a mother in law suite with 1 bedroom, 1 bath, kitchen and sitting area that can be added for an additional $100/night. The property is located behind a private gate. Come relax and enjoy “PARADISE” today!

Guest favorite
The charming cottage features a light yellow exterior and a welcoming front porch, surrounded by mature trees. A small seating area with chairs enhances the outdoor space, while flower pots add a touch of greenery. The tranquil yard offers an inviting atmosphere for relaxation.
Cottage in Lake Village
4.89 out of 5 average rating, 28 reviews

Walk to Lake Chicot: Cottage w/ Yard & Views!

'The Rising Sun' | Updated Interior | Jetted Tub | 0.6 Mi to Town Enjoy a peaceful couple’s retreat at this 1-bed, 1-bath Lake Village vacation rental! The charming cottage has an open-concept living area, a full kitchen, and a private outdoor space with lovely lake views. Sip your morning coffee and relish the tranquil sunrise over the water, then cast a line or make a splash in Lake Chicot. When night falls, unwind back home with a home-cooked meal and a game of chess. It’s up to you!

Top guest favorite
A bright seating area features two armchairs and a sofa, inviting relaxation. A wooden coffee table is positioned in the center. French doors open to a deck, allowing natural light to fill the space and offering a view of the surrounding greenery.
Farm stay in Carthage
4.99 out of 5 average rating, 132 reviews

The Loft, A Little Bluestem Farm-stay

The Loft at Little Bluestem is located on a family-owned working flower farm. Our farm is located just off the historic Natchez Trace Parkway, approximately 45 minutes north of Jackson. We love this place -- from the bluestem grass that grows in our pastures, to the egrets and herons that call our little ponds home -- and we are excited to be able to share these little wonders with you, so that you too can wake up to the sounds of sheep, walk among our flowers, and fish in our pond.

Guest favorite
Home in Hollandale
5 out of 5 average rating, 26 reviews

X Marks the Spot.

Relax with the whole family at X Marks the Spot. Home is completely remodeled. Beautiful Kitchen is waiting for you to prepare a Home cooked meal. Home can sleep up to seven people with 2 Queen Beds, 2 Twin Beds and One rollaway Bed. Onsite laundry room. Nice size TV in the front room to watch, along with TVs in each of the Bedrooms. Come and stay awhile and enjoy this beautiful home. Don't worry about coming home late, this house has Dusk to Dawn automatic recessed lighting.

Guest favorite
A charming cottage is set in a lush green landscape, featuring a wooden porch with seating. The exterior showcases light wood siding and large windows that allow natural light to fill the space. Surrounding trees create a serene atmosphere.
Farm stay in Shaw
4.94 out of 5 average rating, 359 reviews

Peacock in the Delta/ Mississippi Delta Cottage

WELCOME TO PEACOCK-A charming cottage set on a 1,700 acre bucolic farm in the middle of the Mississippi Delta. Private and secure. All guests are welcome to use the swimming pool (June 1-October 2), tennis court, horseback riding, walking trails. We are perfectly located in the middle of the Delta, with close proximity to most blues trail sites. We are also within easy driving distance to most restaurants in the Delta. Need more space? See https://abnb.me/ERkRyvI0rjb

Top guest favorite
The exterior of the cabin is displayed, featuring a sturdy wooden porch supported by steps leading to the front door. Large windows are framed in light wood, allowing natural light. Gravel surrounds the structure, and greenery is visible in the background along with boats at a nearby pier.
Cabin in Yazoo City
5 out of 5 average rating, 15 reviews

The Lazy Wolf

Welcome to The Lazy Wolf! This family-friendly 3-bedroom, 2-bath cabin is perfect for weekend getaways or long, relaxing stays. Enjoy lake views from the screened-in patio, ideal for morning coffee or evening gatherings. The back yard offers, a grill, swing set, fire pit and pier. The property is located near a public boat ramp. Whether you’re looking to unwind or make memories on the water, this cabin has everything you need for a perfect stay.

Top guest favorite
A single-story guest house features a well-maintained, grassy lawn. The front facade includes multiple large windows and a landscaped area with shrubs and trees. A wide driveway leads up to the entrance, providing easy access to the home.
Guest suite in Cleveland
4.97 out of 5 average rating, 275 reviews

The Honnoll's "High Cotton" Guesthouse

This cozy guest house is the perfect place for your stay in Cleveland, MS, the heart of the Mississippi Delta! It is easy walking distance to the Cleveland Country Club and a five minute drive (or less!) to everywhere in town, including the new Grammy Museum, the Downtown shopping area, and the Delta State Campus and Football Stadium! There are Uber and a local taxi company for transportation. We look forward to seeing ya'll!

Guest favorite
A spacious bedroom features warm wooden accents on the ceiling and floor. A king-size bed is centered beneath two lamps, with a decorative ottoman at its foot. Area rugs add texture, while wooden doors provide access to additional spaces.
Guest suite in Kosciusko
4.95 out of 5 average rating, 99 reviews

The Riff House, 2 bedroom guest suite with balcony

The Riff House is a modern luxury guest house above The Guitar Academy in historic downtown Kosciusko. Originally built in 1880 as a hardware store, this building housed Hammond's Hardware for 80 years. This unit is a 2 bedroom one bath suite with a large balcony overlooking the court square. Amenities include refrigerator, microwave, coffee pot, and washer and dryer. This is an upstairs unit without elevator

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Home in Vicksburg
5 out of 5 average rating, 4 reviews

Eagle Lake Hideaway Beautiful Lakefront home

Relax with the whole family at this peaceful place. Eagle Lake Hideaway is a beautiful 3-bedroom lakefront home offering a relaxing retreat on a spacious lot. The pier is shared with one neighboring rental property. Enjoy stunning water views, plenty of space, and all amenities for comfort. Perfect for fishing, boating, swimming, and relaxing, this serene getaway offers privacy and natural charm year-round.

Guest favorite
Home in Belzoni
5 out of 5 average rating, 6 reviews

Easymoney Chalet

Take it easy, unwind and relax at our little piece of heaven in the country. It’s the perfect getaway for hunting weekends with friends and family, blues enthusiasts traveling the blues trail and more. It’s also a quiet place to relax in the MS Delta while you’re attending a special weekend event like a wedding, family reunion or The World Catfish Festival.

Popular amenities for Isola vacation rentals

  1. Airbnb
  2. United States
  3. Mississippi
  4. Humphreys County
  5. Isola