Guesthouse vacation rentals in Doña Ana County

Quaint casita for 2

*Sep 2025 New bed/Aug 2024 New A/C mini split* Quiet cul-de-sac and peaceful landing spot within minutes to NMSU and Old Mesilla. Easy access to I-10 and I-25. Close to golf courses, shopping and the beauty of Las Cruces and Mesilla. Private entrance to casita, patio with dining table and a cozy bedroom, bathroom with tub/shower, WiFi, coffee station, refrigerator with small freezer, microwave. Wonderful hiking trails nearby and less than 60 minutes to White Sands National Park and ELP Airport.

Value · Location · Nearby

Ocotillo Casita in Historic Mesilla

Mesilla STR Permit #0830 We've renovated 90-year-old historic structures to create sustainable, environmental friendly spaces with rainwater harvesting, solar energy, electric solar-powered car charger. This renovated adobe casita is the 2nd structure after our main house. The 3rd is a smaller vacation rental called Yucca Casita. We are within 2 blocks of the historic Mesilla plaza with its farmers market, shops, galleries, restaurants, and walking trails along historic acequias (canals).

Value · Family · Comfort

1 king bd with big fenced back yard pets welcome

Casita La Pacana is nestled in the middle of town surrounded by old pecan trees. Feels like the country but is in the middle of town. 1 bedroom, completely renovated casita that has 1 kind bed, a large living room, streaming TVs in both living room and bedroom, full kitchen including a dishwasher and washer/dryer, hardwood floors, authentic Talavera tile, large shower with a bench seat, huge back yard, and ample parking! This little casita has everything to be your home away from home.

Location · Family · Accuracy

Casita De Cuervo

Casita De Cuervo is a beautiful detached casita. This spacious & quiet casita is very close to popular hiking trails and feels remote while being less than 15 minutes from I-25, NMSU, and both hospitals. This home has a full kitchen, king bed, open living room, work nook, bar stool dining, & much more. Dogs are welcome - there is an enclosed side yard with tall walls for your use. Enjoy the sunrise over the Organ Mountains on the back porch and breathtaking sunset views over the city.

Value · Location · Long stay

Desert Peaks Casita

This lovingly remodeled casita just fifteen minutes from downtown Las Cruces is open, spacious, and comfortably equipped for any length stay. Take in the views of the mountains, watch the birds, or relax in the hot tub under the stars. Hike to the Organ Mountains-Desert Peaks National Monument via an arroyo from the casita, take a dip in the pool, or rest in the peaceful and tastefully decorated space. It is a perfect place for a quiet getaway or as a base to explore the area.

Value · Location · Comfort

Casita at Old Mission near Hatch NM

Have you stayed overnight in a Church before? This is your opportunity. Your lodging in the Casita is attached to the now deconsecrated St Francis de Sales Church, surrounded by a large Spanish courtyard, garden, and a private patio and parking area. Experience the adobe spaces as built in 1860. The church compound is walled and gated. We are located 1 1/2 miles southeast of Hatch in a colonia called Rodey. Look for the bell tower from Hwy 185 and begin your experience here.

Value · Location · Air conditioning

Getaway Guesthouse in Historic Mesilla

Welcome to our cozy guesthouse, just a few blocks away from the Historic Mesilla Plaza. You'll find unique shops, restaurants, bars, and art markets nearby, offering a delightful experience for all your senses! The mouth-watering scents of Chala's Wood Fired Grill and Spotted Dog Brewery will entice you, as they're just around the corner. You'll also hear the bells from one of the oldest churches in the area and enjoy live music from the neighborhood's restaurants and bars.

Location · Family · Laundry

Clara's Nest - The Gem of Hacienda de Las Cruces

Clara’s Nest is in a 1880's adobe compound with its own private entry, courtyard, original stone floors, handcrafted beams, hand-painted bird & flower motif throughout. The suite features a king bed, cozy loveseat & ottoman in the sleeping area, dining table & 4 chairs, kitchenette with micro, fridge, coffee & tea bar, a separate living room with sofa, TV, private bath. Outer space includes: covered patio, backyard, pool and hot tub area (heated upon request) No stove.

Value · Family · Quiet

Cozy Casita w/private patio near Old Mesilla

This adorable Casita is located in a semi-rural area just one mile from Historic Mesilla and 5 min from the interstate. The one bedroom 1 bath casita is perfect for visitors and travelers alike. Furnished with a queen bed, table and chairs and a outfitted kitchenette with microwave/air fry toaster oven/Keurig /double hot plate/ sink and mini-fridge. Also includes Wi-Fi , Smart TV (no cable), mini-split AC/ heater, and a private outdoor patio table and gas grill.

Family · Location · Sleep quality

Casita de Colibrí | Hot Tub • Walk to Old Mesilla

Escape to Casa de Colibrí, a private Southwest-style casita just a short walk from historic Old Mesilla Plaza. Relax in your private hot tub, enjoy the peaceful courtyard, or walk to local restaurants, cafés, shops, and historic sights. Inside, you’ll find a cozy, comfortable space with fast Wi-Fi and everything you need to unwind. A private retreat with Old Mesilla charm, perfect for a relaxing Las Cruces getaway.

Location · Indoor spaces · Hiking

Casa Majik

A two bedroom casita with a kitchen. We have a full bath with tub and shower. Very quiet upscale neighborhood with all custom homes on 1 acre lots. Winding streets perfect for walking or biking. Less than 50 feet from the door of Casa Majik is a trail leading to "A" Mountain. Parking is for a maximum of two cars on the property. Restaurants and Memorial Hospital are 2 miles away.

Value · Location · Breakfast

Rustic Downtown Hideaway

This Rustic guest home has all the amenities, 1 Queen bed, couch sleeps small person or child, and walk-in shower. Inspired by the old west, this guest home has reclaimed wood and tin roof from an old barn in New Mexico. Within walking distance to cafes, restaurants, bars, and shops. Easy private access, keyless entry, and off street parking.

Value · Family · Air conditioning