
Vacation rentals in Clayton
Find and book unique accommodations on Airbnb
Top-rated vacation rentals in Clayton
Guests agree: these stays are highly rated for location, cleanliness, and more.

The Railway Lodge 134 Beulah Lane Mcgregor IA
Welcome to our neck of the woods. Right across the road from Spook Cave sits a nice peaceful cabin with spacious outdoor area. Enjoy a nice fire or simply relax underneath the covered porch with a beautiful pond view. We are located near a train track so don’t be alarmed if one goes by. It actually is pretty neat to see in the dark as your sitting by the fire. We hope you enjoy your stay as much as we love it. Secluded but yet close to town. Feel free to ask any questions. Nathan, Genna Welch

River Trails Cottage
Have fun with the entire family or a group of friends in a quiet peaceful setting. The cabin sits on 2 acres and attaches to 8700 acres of public land that is open to hunting, hiking and abundant with wildlife which makes this property great for the outdoor enthusiast. The property is 6/10 mile from a public boat landing where you can fish, kayak or canoe the Wisconsin River. There are multiple parks relatively close that offer excellent hiking trails. Direct access to miles of ATV/UTV trails.

Ohio Street Retreat- hot tub, massage chair, pool
After a fun day in The Driftless Area, come relax and unwind in Prairie du Chien. Beautifully decorated 2 bedroom home with a spacious kitchen, large island, dishwasher, washer/dryer & 5' walk in shower. We supply all cooking/baking items/utensils. High-speed internet with smart TVs in both bedrooms and living room. Outdoor pool (seasonal), hot tub and massage chair. We love dogs too, so we provide a dog run (there is a pet fee). For our fishermen- there is off street parking for your boats.

Larsen Rustic Secluded Log Cabin W/Outdoor Hot Tub
Secluded cabin hike the trails to the cave and ponds. Close to trout fishing stream or Mississippi for fishing. Bring you UTV and ride the private trails $30 per driver and 10 per passenger or rent an UTV 300.00 per day Approx 15 miles from Priarie Du Chein, close to canoe outposts for the Kickapoo, Wisconsin river. Has a gas ,charcoal grill,fire pit, pool table, fooseball, ping pong table. Smart TV Private UTV trails are closed Oct 15th thru mid Jan for hunting. Access to public UTV trails.

Cozy Apartment Steps from the Mighty Mississippi
Disconnect from the daily grind and enjoy a getaway in this welcoming one bedroom apartment, steps away from the Mighty Mississippi. Located in Clayton, Iowa, Located within walking distance of two delicious restaurants and a boat launch., and only 1/2 hour from the Casino Queen, local wineries, Pikes Peak State Park, as well as the historic communities of Elkader, IA and Prairie Du Chien, WI. Need more space? I also offer a two bedroom apartment: www. airbnb. com/rooms/43979345

Unplug and get back to nature
The log cabin was built as a place to unwind, relax, and truly unplug. Nestled among 15 acres of rolling hills, the cabin can serve as a place to hunker down and read three novels, or a home base for hiking, cycling and putting the nature back in your life. Be advised, there is NO television and that’s for good reason. Cook, drink, eat, play, relax and refresh yourself. Wake up to the songs of birds and listen to the owls at night while you’re warming yourself around a bonfire.

Historic Charm in the Heart of McGregor, Iowa
2 Bedrooms • 1 Bathroom • Walk to the Mississippi River Welcome to your cozy getaway in the scenic river town of McGregor, Iowa! This beautifully updated two-bedroom, one-bath home combines small-town charm with modern comfort — perfect for couples, families, or friends looking to relax and explore. A bright, open living area with comfortable seating and local decor A fully equipped kitchen with everything you need to cook and dine in. Two spacious bedrooms with plush bedding.

Paradise Point sleeps 2 Hot Tub
1 bedroom 1 bath with loft. Cozy home where you can see Paradise. This memorable place is anything but ordinary. Views for miles of the Mississippi River, bluff tops and you can soar with the Eagles. What a place to relax in the newly added hot tub while you enjoy the view in what is call "God's Country". This is promised to be a one of a kind view. The Deck with comfortable outdoor seating Located in the heart of WIsconsin's Driftless Region.

Clayton Riverway House~ River front home
Sit back and relax in a home that is directly on the Mississippi River in Clayton, Iowa! Enjoy watching the trains, barges and river traffic, fishing off of the private or public dock, or spending time with your friends and family in this quaint river town. Northeast Iowa has many activities to enjoy, such as boating, fishing, hiking, hunting, antiquing. Riverway House is the perfect place to stay while enjoying the beauty of Clayton County.

Mississippi Retreat: Scenic Views + Unique History
Discover the charm of this historic home, originally the Clayton Savings Bank built in 1915, now transformed into a spacious and inviting retreat just steps from the Mississippi River. With its preserved original bank vault, this home offers a one-of-a-kind blend of history and comfort. Enjoy breathtaking views of the river and surrounding bluffs from the large living area, which boasts high ceilings and plenty of natural light.

McGregor Bedside Manor
Spacious two bedroom, two full bath ranch style home in the heart of McGregor, Iowa, within walking distance to local shops and the Mississippi River. Large driveway to park your car/truck and boat. There is a full kitchen, dining area, laundry room, work desk, and covered deck where you can sit and relax with your coffee or a cool drink. 75 inch smart TV in the living room, as well as one in each bedroom.

1884 Red Brick Cottage
Step back in time to a quiet small town in Iowa, nestled within the hills of the driftless area. Time seems to stand still while you're here. The 1884 Red Brick Cottage offers 3+ Bedrooms in a peaceful neighborhood, close to riverfront activities, casino and downtown Marquette. Spacious backyard and sideyard, house is fully furnished and includes a firepit and gas grill for evening outdoor activities.
Popular amenities for Clayton vacation rentals
Other great vacation rentals in Clayton

Dam River Penthouse

Secluded Bardo Retreat w/ Hot Tub + View

Rustic 3Bed 2Bath Home near Downtown PDC

Spacious BnB with THE BEST Mississippi View

August & Alma’s

Pleasant Ridge Retreat

River Bluff Retreat-Hot tub & game room

Cozy Casita
Destinations to explore
- Chicago Vacation rentals
- St. Louis Vacation rentals
- Minneapolis Vacation rentals
- Milwaukee Vacation rentals
- Omaha Vacation rentals
- Des Moines Vacation rentals
- Saint Paul Vacation rentals
- Downtown Chicago Vacation rentals
- Duluth Vacation rentals
- Sioux Falls Vacation rentals
- Grand Rapids Vacation rentals
- Wisconsin Dells Vacation rentals





