
Places to stay near Buffalo Museum of Science
Book unique vacation rentals, homes, and more on Airbnb
Top-rated vacation rentals near Buffalo Museum of Science
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The 2D Spot!
Buffalo's 1st official 2D Airbnb; all hand painted by local Artists. With ideal proximity to DT Buffalo, Elmwood Village & Allentown, you'll find yourself at the heart of the city's culture. Also just a 25 minute drive to the iconic Niagara Falls. Whether you're a first time visitor to Buffalo or a local seeking a unique escape, The2DSpot invites you to step inside the pages of a comic book. Immerse yourself in a world of imagination & book your stay today! Experience Buffalo like never before.

Historic Apartment Steps Away from Allentown Area
This spacious 1-bedroom apartment is conveniently located in the heart of Allentown. It is fully furnished and includes everything you will need to have a comfortable, enjoyable stay. This is 1 of 3 airbnbs located in a historic multi-unit home. This space is the perfect getaway for couples, business stays, and traveling nurses. It is situated in a quiet residential neighborhood, steps away from Allen St. The front door opens to a small park that was designed by Frederick Law Olmsted in 1887.

Luxury Spa Loft Gym Fireplace Basketball EV+
Ideal for extended stays, this stunning luxury loft is located in an architecturally significant building in the heart of Elmwood Village and nearby Allentown. Enjoy access to top-notch amenities, including gym, dedicated work area & indoor basketball court. The loft features a unique layout with spa like amenities, couples shower and wet room, fully equipped gourmet kitchen, elegant marble finishes. Serene sunken living/sleeping area, with queen bed, gas fireplace, 65", standup work desk.

Modern Full Home: Hot Tub, Updated Kitchen & Bath
**This is an entire home listing. There is no one else that will be at the house.** Enjoy a stylish experience at this centrally-located single family home. With an updated kitchen, a/c downstairs master BR, guest BR and attic (may-sept). Ultra modern bathroom has a walk-in shower with 2 rain shower heads, 1 extra deep bathtub, heated floor, marble counter tops & bidet Outside you will have a large back porch which includes a hot tub & string lights to enjoy during the cool Buffalo evening.

Five Points Hideaway
Welcome to 5 Points! Offering a private, hotel room style- 1 bedroom/1 bathroom guest suite attached to a historic home in the heart of the Five Points neighborhood on Buffalo’s Westside. Private entrance. This cozy spot is perfect for an overnight or weekend visit. Mini fridge, microwave and Keurig provided. Just 8 minutes from Downtown and 25 minutes from Niagara Falls. Walking distance to great restaurants and bars. Close to Buff State, AKG, Medical Campus, Convention Center & Arena.

Charming 4BR 2ba Buffalo Home by Parks, DT, Fun
Enjoy the unique charm of this 2,200 sq ft historic home. Gather in the light-filled, open living area featuring century-old woodwork, or cook together in the fully equipped kitchen. Upstairs, 4 roomy bedrooms comfortably sleep 8. Whether you need to catch up on remote work in the quiet office, unwind in the dedicated Zen room, or grill on the private patio, there’s space for everyone. Best of all, you’re just 7 minutes from downtown and 15 from the airport. Book your seamless stay today!

Cozy Apartment in LarkinVille (Unit 2)
If this listing is not available please check out my other listings This 1st floor apartment features an open concept kitchen & living room with stove, refrigerator & microwave. A queen sleeper sofa & 54" smart TV are in the living room. The bedroom has a queen bed & dresser. The space features a In unit washer & dryer soaker jacuzzi tub and A/C mini split to help cool down the space. This is a mix use property with periment tenants as well as other guest. Noise is typically low

Five Points Apartment- Upper Unit
Updated Upper Unit Apartment. Great City Location! Walking Distance to Five Points, and Lower West Side Restaurants and Shops. Off Street Parking (when available). In Unit Laundry. WiFi. Pets Allowed ($50 pet fee). Queen Bed and Fold Down Futon. Blocks from D’Youville University and minutes from Buffalo State University! Close to Kleinhans Music Hall, Elmwood Village and Allentown! 10 Min Drive To KeyBank Center - 20 Min Drive To Highmark Stadium - 20 Min Drive To Niagara Falls

Cozy S. Buffalo Retreat - 10 mins to Bills Stadium
Welcome to our beautifully remodeled upstairs studio in South Buffalo! Just 10 minutes from the Buffalo Bills stadium and close to vibrant nightlife, dining, and casinos. Niagara Falls is a scenic 20-minute drive away. The studio features a fully equipped kitchen, a cozy pillow-top queen bed, a living area with a 55" smart TV, an electric fireplace, and a spacious bathroom. Enjoy in-unit laundry and free off-street parking. Experience all the comforts of home!

Private City Escape in heart of Elmwood Village
This charming and cozy hideaway is within walking distance of the restaurants, museums, parks, and entertainment that makes Buffalo, NY famous. Within 15 minutes of the Peace Bridge Canadian border crossing. Close to Niagara Falls, waterfront attractions and downtown. Fully furnished with queen-size bed, linens, towels, fully equipped kitchen, appliances, and a newly renovated bathroom. Private entrance, laundry facilities, Internet, TV, and basic cable.

Clean 2-Bedroom Apt (11 min to DT, 12 to stadium)
Keep it simple yet cozy in our comfortable, centrally-located apartment! This quiet, dead end street is nestled in the center of a vibrant, up and coming part of town. All amenities included - free street parking, WiFi, central heating, and everything you may need to make your stay a good one. We are only 11 minutes from the city, 5 minutes from the thru way, and within walking distance to many restaurants, shops and markets, parks, and a golf course!

Timber-frame home on 12 wooded acres
Featured in Buffalo Spree and Artvoice, this timber-frame home features stunning hickory and black walnut interiors illuminated by two-story windows that face the morning sun. Radiant floor heating and earthen-plaster climate design. Wake up in queen and king beds, lounge under covered verandas, and shop right next door at Thorpe’s organic farm store. • 7 minutes from the Village of East Aurora • 24 minutes from Bills stadium • 1 hour from Niagara Falls
Popular amenities for vacation rentals near Buffalo Museum of Science
Condo rentals with wifi

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Family-friendly house rentals

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Modern Kenmore Getaway | Renovated Home in Buffalo

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West Side Retreat Steps from Allentown & Downtown

The Italianate: Historic Home w/ Sauna and Firepit
Apartment rentals with air conditioning

Buffalo - Black Rock Apartment

ArtairNorwood

Peaceful Walkable 1 Queen Upper+parking+laundry

Cozy & Walkable Elmwood Village Charmer

Charming Upper in Lively Entertainment District

Cozy 2 Bedroom Apt Close 2 Everything

Modern & Large Apt in Downtown Allentown 2B2B

Family/Pet-Friendly | Driveway Parking
Other great vacation rentals near Buffalo Museum of Science

Charming 2 bedroom cottage on the EA golf course

*NEW* Bungalow in Williamsville!

Large 2 bed 2 bathroom loft in East Aurora Village

Stunning Victorian 3bed - Elmwood Village

Luxury Work From Home 2-Bedroom

Nice house with king bed 25min to Niagara falls

1st Floor Charmer in West Side

1-Bedroom Harbourtown Beach Unit, mins from beach
Destinations to explore
- Letchworth State Park
- Six Flags Darien Lake
- Holiday Valley Ski Resort
- Niagara Falls State Park
- Niagara Falls
- Buffalo RiverWorks
- Casino Niagara
- Fallsview Indoor Waterpark
- Brock University
- Jackson-Triggs Niagara Estate
- University at Buffalo North Campus
- Seneca Niagara Resort & Casino
- Knox Farm State Park
- Keybank Center
- Vineland Estates Winery
- 13th Street Winery
- Kissing Bridge
- Wayne Gretzky Estates
- Buffalo Zoo
- MarineLand
- Lakeside Park Carousel
- Highmark Stadium
- Genesee Country Village and Museum
- Balls Falls Conservation Area





