Vacation rentals in Santa Cruz County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite

A hammock is gently draped between two trees, with the fabric partially visible in the foreground. The background features a stunning sunset, casting soft hues across the sky. The landscape is open, with sparse vegetation and rolling hills creating a tranquil environment.

Guest suite in Nogales

4.94 out of 5 average rating, 128 reviews

Patagonia Lake Hideaway

PRIVATE SPACE! $105 p nite NO CLEANING FEES but airbnb charges its own fees. king bed, sofa, picture window,french doors, electric fireplace, Private courtyard, patios, gardens,sunrise over Patagonias,sunset behind the Atascosas. Birding paradise.Also great for hunters, hikers.Lake minutes away with boat rentals, swimming, fishing, hiking, small beach. Easy travel toTombstone, AZ Trail, Tubac, Golf Course, Kartchner caverns, Patagonia, Mexico, wine and spirit tasting .check in/check out flexible

Top guest favorite

A spacious room features a comfortable king bed and a cozy seating area with a sofa. Natural light filters through windows, illuminating the neutral colors of the decor. A kitchenette with a coffee maker and a small fridge is also visible, enhancing convenience for guests.

Guest suite in Tubac

4.95 out of 5 average rating, 237 reviews

Private Tubac Retreat under The Milky Way

A tranquil, spacious, and beautiful Casita. Comfortable King bed with a gel memory foam mattress, additional pillows and blankets for your convenience, private bathroom, microwave, small fridge, toaster, coffee maker, and teas and coffee for a quick bite. Private entrance and a small patio with seating area, which leads to the staircase to the roof where you can enjoy the view during the day and the Milky Way at night. Large screen TV with Netflix and Hulu (bring your own passwords), and Wi-Fi.

Guest favorite

The bedroom features a king-size bed with a light blue quilt and two accent pillows. Soft yellow curtains frame the window, allowing natural light to fill the space. Two bedside lamps with red shades illuminate the room, and a framed artwork hangs above the headboard.

Guest suite in Tubac

4.96 out of 5 average rating, 136 reviews

Tubac Golf Resort Casita - long stay discounts

The casita is centrally located between the Tubac Golf Course and Tubac village. The casita has a private bedroom and bathroom with outside entrance with dog door. The beautiful private yard has a covered porch, outdoor kitchen, and chiminea. Inside the casita is a king-size bed, table and chairs, refrigerator, microwave and coffee pot. Amenities include WIFI, local TV, Peacock. Weekly and long stay discounts. Early checkin and late checkout available upon request. Lockbox with code provided.

Top guest favorite

A brass bell is prominently displayed against a dark sky, capturing attention with its polished surface. It hangs from a metallic arm, showcasing detailed craftsmanship, while the surrounding structure is minimally visible in the foreground.

Apartment in Tubac

4.99 out of 5 average rating, 205 reviews

Coolest AirBnB in Tubac-Private Unique Free Charge

Located in the historic district of the village; a Tubac icon. Drive for free ... charge with my Level 2 solar while you're here; house is 100%, solar. Private, secure, best location, warm weather, fast Internet, new and comfy bed, complete kitchen, high quality AC, quaint, free easy parking, washer/dryer, walled courtyard with a fountain, walk-in shower, light blocking shades. Eight excellent restaurants within 1 mile. An exceptional value, best price, no deposit or cleaning fees

Top guest favorite

A spacious bed is dressed in neutral linens, flanked by two nightstands with decorative lamps. Orange accent pillows add color, while a cozy throw rests at the foot of the bed. Two ottomans provide additional seating at the base.

Apartment in Tubac

4.97 out of 5 average rating, 105 reviews

Newest! Private Tubac Hacienda

Newly remodeled AirBnb in the heart of Tubac! Large hacienda with full kitchen and master bedroom with KING bed. Stunning tile bath and private covered parking. We offer WiFi with an oversized desk for a spacious "away from home" workspace. And, due to current world health concerns, we want you to know that we are doing our part to help out AirBnb guests stay safe by disinfecting frequently touched surfaces (light switches, door knobs, cabinet handles, remotes, etc.) before you checkin.

Top guest favorite

A dining area features a long wooden table surrounded by six dark chairs. A large chandelier shaped like a star hangs above the table, casting intricate patterns on the walls. A decorative centerpiece of fresh fruits adds a touch of color.

Home in Tubac

5 out of 5 average rating, 123 reviews

A Tubac Getaway

Amazing luxury vacation rental in beautiful, historic Tubac, Arizona. Located in The Sanctuary neighborhood, this home is within walking distance of either The Village of Tubac or the Tubac Golf Resort. Plenty of nearby activities including hiking, golf, birdwatching, or day trips to southern Arizona. Visit unique shops in The Village of Tubac or the Resort for furnishings, jewelry, or great food at a variety of restaurants. Come see everything that southern Arizona has to offer!

Guest favorite

A spacious living area features a light-colored sofa with colorful accent pillows and a glass coffee table. Artwork adorns the walls, while natural light filters in through a window. A dining area with chairs and a modern workspace is visible in the background.

Home in Patagonia

4.93 out of 5 average rating, 91 reviews

Cottage on Santa Rita | Sundrenched 2 bd/1 bth

Nestled against the hill, this private, sun-filled home is located in the heart of Patagonia, a few quick steps to local businesses. Expansive patios and a cactus garden provide a hidden oasis behind the cottage - an ideal base for exploring the region's wineries, historic towns, gravel cycling, and forests. The home is fully updated, with a generously equipped kitchen, large master bedroom, washer/dryer, flexible second sleeping space, and tasteful minimalist southwest decor.

Guest favorite

A spacious living area is highlighted by an 18-foot rock fireplace featuring an elk mount. Comfortable seating arrangements include a leather sofa and coffee table, set on a textured rug. A staircase leads to the upper level, with natural light entering through large windows.

Home in Arivaca

4.93 out of 5 average rating, 160 reviews

Wildlife Adventure Ranch Lodge

Escape to the rugged beauty of Arivaca, Arizona in this spacious 3-bedroom, 2-bathroom hunting lodge. Featuring a stunning 18-foot rock fireplace with an elk mount, this lodge is perfect for outdoor enthusiasts, birdwatchers, and stargazers. Enjoy garage parking, three washer/dryer units, a fenced yard, and both ground-level and second-story decks. Play cornhole, relax under the stars, or explore nearby attractions like Arivaca Lake and the border wall in Sasabe

Top guest favorite

A single-story building constructed with natural stone and warm-toned stucco is set against a backdrop of grassy landscaping. A covered outdoor area is visible, along with a clear sky, creating a serene and peaceful setting.

Cottage in Patagonia

4.97 out of 5 average rating, 109 reviews

Country house with spectacular views

Disconnect from your worries in this spacious and serene private space, where you can enjoy natural light, contact with nature and beautiful natural views. It has a fully equipped kitchen, dining room, living room, living room with TV and reclining armchairs, 3 large bedrooms, a game room, laundry room and a beautiful porch where you can rest in the living room or in the outdoor dining room as well as enjoy beautiful sunsets. It also has a kiosk with lighting.

Guest favorite

A refreshing saltwater pool is framed by a spacious deck, lined with comfortable lounge chairs. The surrounding landscape features native plants and offers expansive views of the desert terrain and distant mountains under a dramatic sky.

Cottage in Patagonia

4.96 out of 5 average rating, 110 reviews

Kestrel Cottage at Birdsong Retreat

ATTENTION SUMMER BOOKINGS: Swamp cooler and wall unit in queen bedroom. We provide fans. With monsoon rains, it’s too humid to use swamp cooler. Unit is priced to reflect the heat. Escape to serene high desert grasslands in Patagonia, AZ, offering 360-degree views at 4,058 feet offering respite from the Phoenix and Tucson heat. Nestled within BirdSong Retreat on 37 acres, the Kestrel Cottage promises luxurious accommodations and a focus on well-being.

Guest favorite

The guesthouse features a cozy sleeping area with a spacious bed dressed in simple linens. A comfortable sofa is positioned next to a wood bookshelf, which holds various decorative items. A desk and chair provide a dedicated workspace, with natural light filtering through the curtains.

Guesthouse in Rio Rico

4.87 out of 5 average rating, 354 reviews

Cozy Rio Rico guesthouse with a view

This spacious guesthouse is in an ideal rural setting. Located near the Mexican border, the art community at Tubac, and the old Spanish mission of Tumacacori, there is lots to see and do. (Not to mention many good golf courses.) I am looking forward to your visit! To make your stay both pleasant and sanitary I steam clean floors, sani-wash all linens and towels, and wipe counters, sinks and toilet with sanitizer spray. Rest easy here!

Top guest favorite

A charming guesthouse exterior is highlighted by a warm brick façade and olive green walls. The front door, adorned with a decorative wreath, opens to a welcoming entryway. Potted plants flank the entrance, complemented by a comfortable seating area beside the door.

Guesthouse in Patagonia

4.93 out of 5 average rating, 121 reviews

Mesquite Cottage

A guesthouse, nestled in a grove of mesquite trees, located just a block away from the local shops downtown awaits your arrival. A full kitchen, supplied with the basic conveniences, bedroom with queen size bed and twin sofa bed, and bathroom with shower, make this space a perfect fit for a couple or small family. The front living room has a futon couch and smart TV.