Vacation rentals in Santa Cruz County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Santa Cruz County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Superhost

The exterior features a welcoming entrance with a combination of rustic and vibrant elements. Adirondack chairs in turquoise and red are positioned in a small patio area, and a flag is displayed prominently. Native landscaping complements the porch area, creating a friendly ambiance.

Home in Patagonia

4.84 out of 5 average rating, 148 reviews

Javelina Corner

Our place is close to Patagonia Lake, 10 minute drive, Patton's hummingbird center, 2 minute drive or 8 minute walk. There is access to the Arizona trail at two locations within 10-20 minute drive and numerous other hikes! Tombstone, Bisbee, The Art haven of Tubac is close by and Nogales Mexico is 19 miles. You’ll love our place because of the neighborhood, the coziness, and the comfy beds. Our place is good for couples, solo adventurers, business travelers, families , and furry friends (pets).

LocationValueWalkability

Guest favorite

A charming adobe-style guesthouse features a covered porch with seating areas. Natural stone pathways lead to the entrance, flanked by desert landscaping and potted plants. The exterior showcases warm earth tones with a tile roof, surrounded by open skies and a peaceful atmosphere.

Guesthouse in Tubac

4.86 out of 5 average rating, 115 reviews

Amazing Casita at the Tubac Resort-Self check-in*

Take it easy at this unique and tranquil getaway in the beautiful and historic Tubac Golf Resort. Located in a quiet neighborhood just a 5 minute walk to resort amenities including, spa, salon, resort shops, and Stables restaurant. Our Guesthouse includes a king bed, Sofa bed, personal driveway to park your car, private entrance, beautiful terrace, fireplace, Smart TV, internet, coffee maker, microwave, and mini refrigerator. Known as a center of art and history, is truly worth the visit.

LocationValueWifi

Top guest favorite

Guesthouse in Patagonia

4.99 out of 5 average rating, 117 reviews

Casita de Suenos

Replenish * Re-calibrate * Reconnect.. Welcome to our little house of dreams! You have found the perfect leaping off point to explore all this region has to offer. Nestled snugly between the Patagonia and Santa Rita mountains, our casita sits at just under 5,000 ft, making it temperature perfect almost year round. Enjoy our 38 acres and private hiking trails right out the front door with endless possibilities for adventure. Recharge, Rejuvenate, and Revel in our cozy, clean, quite space.

LocationFamilyKitchen

Top guest favorite

A dining area features a long wooden table surrounded by six dark chairs. A large chandelier shaped like a star hangs above the table, casting intricate patterns on the walls. A decorative centerpiece of fresh fruits adds a touch of color.

Home in Tubac

5.0 out of 5 average rating, 143 reviews

Una Escapada en Tubac

Amazing luxury vacation rental in beautiful, historic Tubac, Arizona. Located in The Sanctuary neighborhood, this home is within walking distance of either The Village of Tubac or the Tubac Golf Resort. Plenty of nearby activities including hiking, golf, birdwatching, or day trips to southern Arizona. Visit unique shops in The Village of Tubac or the Resort for furnishings, jewelry, or great food at a variety of restaurants. Come see everything that southern Arizona has to offer!

ValueFamilyAmenities

Top guest favorite

A hammock is gently draped between two trees, with the fabric partially visible in the foreground. The background features a stunning sunset, casting soft hues across the sky. The landscape is open, with sparse vegetation and rolling hills creating a tranquil environment.

Guest suite in Nogales

4.94 out of 5 average rating, 153 reviews

Patagonia Lake Hideaway

PRIVATE SPACE! $105 p nite NO CLEANING FEES but airbnb charges its own fees. king bed, picture window, sofa, french doors,electric fireplace, tv, Private courtyard&patio, sunrise over Patagonias,sunset behind the Atascosas. Birding paradise.part of Madrean sky Island.Lake minutes away with boat rentals, swimming, fishing, hiking, small beach. Easy travel toTombstone, AZ Trail, Tubac, Kartchner caverns, Patagonia, Mexico, wine and spirit tasting .check in whenever.check out 5pm

ValueLocationLayout

Top guest favorite

A refreshing saltwater pool is framed by a spacious deck, lined with comfortable lounge chairs. The surrounding landscape features native plants and offers expansive views of the desert terrain and distant mountains under a dramatic sky.

Cottage in Patagonia

4.97 out of 5 average rating, 132 reviews

Kestrel Cottage at Birdsong Retreat

ATTENTION SUMMER BOOKINGS: Swamp cooler entire cottage and AC wall unit in queen bedroom. We provide fans. With monsoon rains, it’s too humid to use swamp cooler. Cottage priced to reflect the heat. Escape to serene high desert grasslands in Patagonia, AZ, offering 360-degree views at 4,058 feet offering respite from the Phoenix and Tucson heat. Nestled within BirdSong Retreat on 37 acres, the Kestrel Cottage promises luxurious accommodations and a focus on well-being.

ValueLocationSleep quality

Top guest favorite

A Santa Fe style residence is framed by native desert vegetation, including cacti and broader plants. A winding pathway leads toward the whitewashed exterior, partially obscured by trees, enhancing the natural surroundings of the peaceful community.

Home in Tubac

5.0 out of 5 average rating, 22 reviews

Mesquite Haven

Fantastic home located in a peaceful and beautiful community surrounded by desert nature. This Santa Fe style residence invites you to relax and escape a busy lifestyle while still having access to modern amenities. Enjoy life outdoors in a basically traffic free private community rich with local flora and fauna. The location is great for morning or evening walks or runs, Tubac Resort wedding guests, visits to the village, hiking trips, etc.

LocationFamilyTV

Guest favorite

The guesthouse features a cozy sleeping area with a spacious bed dressed in simple linens. A comfortable sofa is positioned next to a wood bookshelf, which holds various decorative items. A desk and chair provide a dedicated workspace, with natural light filtering through the curtains.

Guesthouse in Rio Rico

4.87 out of 5 average rating, 378 reviews

Cozy Rio Rico guesthouse with a view

This spacious guesthouse is in an ideal rural setting. Located near the Mexican border, the art community at Tubac, and the old Spanish mission of Tumacacori, there is lots to see and do. (Not to mention many good golf courses.) I am looking forward to your visit! To make your stay both pleasant and sanitary I steam clean floors, sani-wash all linens and towels, and wipe counters, sinks and toilet with sanitizer spray. Rest easy here!

LocationFamilyCleanliness

Top guest favorite

The home is set under two large oak trees, providing a natural shaded environment. A spacious outdoor area is visible, featuring a patio with seating. Surrounding greenery enhances the serene landscape, while a fenced yard adds to the property's secluded feel.

Cottage in Sonoita

4.96 out of 5 average rating, 225 reviews

Under the Oaks

Escape to the peaceful beauty of Under the Oaks, nestled beneath three magnificent oak trees with sweeping views of rolling grasslands and distant mountains. Relax in the spotless, comfortable home, unwind on the screened porch as the sun sets, or enjoy birdwatching, grilling, and a glass of local wine beneath the spacious ramada. Shady oaks, abundant wildlife, and tranquil surroundings create the perfect Southern Arizona getaway.

FamilyLocationAccuracy

Top guest favorite

A green casita is situated in an open landscape, surrounded by a rustic fence. A gravel driveway leads towards the entrance, with an American flag waving gently overhead. Lush grass and a few scattered trees enhance the rural setting under a clear blue sky.

Home in Sonoita

4.98 out of 5 average rating, 290 reviews

Sky Island Retreat Sonoita, AZ.

Sky Island Retreat is a quiet and peaceful hilltop retreat in which you can relax and enjoy the natural beauty of this historic area. The casita is the original but updated ranch house built in the late 60’s. We have kept much of its original charm while upgrading to modern comfort and conveniences. We are located on a privately gated property just minutes from the heart of Sonoita and Southern AZ’s growing wine country.

ValueFamilyBathroom

Top guest favorite

A clear blue pool is visible, reflecting sunlight under a vast sky adorned with fluffy white clouds. The surrounding landscape features rolling hills and mountains in the distance, highlighting the serene nature of the location.

Home in Patagonia

4.95 out of 5 average rating, 73 reviews

Poolside Escape Near Patagonia

Unwind at this scenic hilltop retreat just a mile south of Patagonia, AZ. Enjoy a private pool with stunning Red Mountain views, 3 spacious bedrooms, and a dedicated office space. Close to hiking, biking, and town. Relax in modern comfort, soak up breathtaking sunsets, and explore the best of Southern Arizona. Pet-friendly for making memories with the whole family!

ValueLocationBiking

Guest favorite

The exterior of the home is presented, featuring a modern single-story structure framed by desert landscaping. A gravel pathway leads to the entrance, while two trees provide a natural element. A colorful sky is visible, suggesting a vibrant sunset.

Home in Rio Rico

4.98 out of 5 average rating, 44 reviews

Large group getaway - 4 bed w/ updated appliances

Welcome to this new construction 4-bedroom, 2-bathroom home in Rio Rico! Perfect for families or groups. Enjoy an open-concept living space with a gourmet kitchen, granite countertops, and stainless steel appliances. Visit nearby attractions such as Tumacácori National Park, explore nearby Tubac & Nogales AZ, or enjoy family time by the fire pit!

LocationFamilyCondition