Vacation rentals in Osborn Medical Center, Phoenix

Paradise Found, Conferences, Concerts, GCU, Pool

The historic Willo district of Central Phoenix is the perfect location to relax. Close to many attractions and major freeways, this completely renovated mid-century home offers the ultimate in both luxury and high-end fixtures. Inside, you can pamper yourself in the deep tub (with endless hot water) or multi-faucet shower, snuggle in the luxurious beds, or just laze in front of the 65" 4K TV. Outside, you can relax beside the pool (ask about heating), or just gather under the shaded patio.

Luxe Historic Casita w/ Free Parking: Casa Pascual

NEW! Welcome to Casa Pascual, a 1938 casita in Phoenix’s historic Willo neighborhood. This elevated cozy retreat blends Southwest style with Latin warmth, featuring clean lines, earthy tones, and natural accents. Enjoy a serene escape while being close to Encanto Park, the Heard Museum, and downtown Phoenix. Experience a perfect mix of comfort and cultural richness, with easy access to local attractions and a peaceful atmosphere to return to after exploring the vibrant area. IG: casapascualphx

Midtown Oasis-Great Outdoor Space & Location!

Perfectly located, this Central Phoenix retreat is a remodeled, immaculately kept, Central Phoenix home built in 1944. It is beautifully furnished with everything you need for a comfortable stay. Included is a relaxing outdoor space to enjoy morning coffee or BBQ dinner. It is on a quiet street on the grand canal, walking distance to the light rail, restaurants, cafes, bars, museums, Steele Indian School Park (one of the largest parks in Phoenix), and all the attractions in downtown Phoenix.

PHX's Modern Midtown Carriage House, Free Parking

Experience the perfect blend of historic charm and modern comfort in the heart of Phoenix's Midtown. Our beautifully designed Carriage House offers a unique guest quarters, complete with a full kitchen, luxurious queen bedding, and a private patio. Step outside and explore the vibrant neighborhood, filled with local restaurants, shops, and cultural attractions. Book your stay at the Midtown Carriage House today and discover the best of Phoenix living. check out on insta @midtowncarriagehouse

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Private, desert-chic casita in vibrant Midtown PHX

Welcome to Casita Amelia, a modern rustic retreat central to all the action Phoenix has to offer. Welcoming and cozy, this newly updated private guest suite has all the luxuries of a modern hotel suite while being quietly tucked away in a cute Midtown neighborhood. Walk to Melrose District. You're also just 5-10 mins by car to Uptown & Camelback Corridor, 10 mins to Downtown (Footprint Center, Chase Field, Arizona Financial), 15 mins to Sky Harbor Airport, and 20 mins to State Farm Stadium.

Central PHX Lux Historic Villa + Heated Pool & Spa

Built in 1928, yet fully remodeled and professionally decorated, this Spanish Colonial Revival masterpiece on an idyllic palm-lined avenue adjacent to Encanto Park is the ideal getaway. Stroll the surrounding storybook lanes, cool off in the private pool, soak in the hot tub, lounge by the fire pit, or sleep late in one of 3 luxuriously appointed King bedrooms, including a main floor primary with en-suite bath. 2-car off-street parking and super-fast wifi make this the ideal home base.

Modern Midtown Oasis with Pool, Spa, & Roof Deck

Featured in Phoenix Home & Garden, this designer-renovated 1920s home blends timeless elegance with modern luxury. Enjoy a 3BR/2BA main house, stylish pool house, chef’s kitchen, saltwater pool and spa, moody lounge with wet bar, and refined indoor-outdoor living—all in the heart of Midtown Phoenix. Walking distance to the LightRail, Restaurants, Bars, The Heard Museum, Phoenix Theater & Phoenix Art Museum! Easy train access to/from SkyHarbor Airport and everything Phoenix offers!

The Beverly Bungalow | Stylish Stay Near Downtown

Relax & unwind at our mid-century bungalow in the heart of Phoenix. This 1BR/1BA condo will comfortably sleep 2. Our condo is complete with a full kitchen, cozy living room & dedicated work space for the WFH professional. Also included is a shared pool/hot tub to cool off on those hot summer days. Located in Midtown center to museums, unique bar & restaurant concepts, Chase Field, The Footprint Center - the list goes on. We hope you enjoy all AZ has to offer!

Guesthouse in city's most walkable neighborhood

Central location, easy access to I-10, I-17, 202, 51, and 9 minutes from Phoenix Sky Harbor Airport. Amenities abound in this updated private studio guesthouse in the upscale Encanto-Palmcroft Historic District of downtown Phoenix. Homes here have stunning architectural diversity. Recently ranked the wealthiest neighborhood in Phoenix, Phoenix Magazine named Encanto-Palmcroft 2009's "Best Places to Live" and the "Best Neighborhood to Walk Through" in 2015.

Uptown Historic Home | Resort Style Outdoor Space

Experience Monarch House in a Phoenix Historic District—your spa-like retreat with unique artistic touches. The well-designed interior features a dining room and a fully equipped kitchen, perfect for memorable meals. Located in Uptown Phoenix, enjoy trendy restaurants, local boutiques, and vibrant nightlife just minutes away. Seamlessly switch between two private outdoor spaces and a shared courtyard, featuring an outdoor dining room and cozy fire pit.

Adorable Willo Cottage in Historic Central Phoenix

Peaceful one bedroom cottage in unbeatable location within Central Phoenix. Walking/ biking distance from light rail, restaurants, Heard Museum and Phoenix Art Museum. Enclosed backyard with a shared washer/dryer on property. The cottage has a queen bed, mini kitchen and private patio. Property is cleaned and sanitized according to the Airbnb cleaning procedures. 15 minutes from Sky Harbor Airport. 5 minutes from Encanto Park (Golf Course)