Vacation rentals in Osborn Medical Center, Phoenix

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Top-rated vacation rentals in Osborn Medical Center, Phoenix

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Superhost

A welcoming living area features two brown leather sofas positioned around a vibrant area rug. A coffee table is centered between them, and a television is mounted on a green accent wall. A potted plant adds a touch of greenery, enhancing the space's warmth.

Condo in Encanto

4.9 out of 5 average rating, 173 reviews

The Beverly Bungalow 1BR/BA in the 🖤 of Phoenix

Relax & unwind at our mid-century bungalow in the heart of Phoenix. This 1BR/1BA condo will comfortably sleep 2 (up to 4 using an air mattress). Our condo is complete with a full kitchen, cozy living room & dedicated work space for the WFH professional. Also included is a shared pool/hot tub to cool off on those hot summer days. Located in Midtown center to museums, unique bar & restaurant concepts, Chase Field, The Footprint Center - the list goes on. We hope you enjoy all AZ has to offer!

Top guest favorite

The pool area is surrounded by lush tropical landscaping, with shaded seating nearby. Sunshades provide protection from the sun over the shimmering water, creating a serene atmosphere. Natural stones and greenery enhance the tranquil setting, inviting relaxation and enjoyment.

Place to stay in Phoenix

4.97 out of 5 average rating, 1,033 reviews

Guest House 1 King Bed Pool/Jacuzzi/urban Phoenix

“CHECKING IN INSTRUCTIONS”at “GUEST RESOURCES”on Airbnb. PLEASE NO EARLY CHECK-IN due to time constraints. The guest room air conditioner/heater/king size bed/linens/Plates/glasses-all plastic, towels/wifi/premium cable with movies Premium internet. Guest house 275 sq feet There is street parking with parking permit available. Alwa NO SMOKING of any products inside guest house Property 420 friendly only in outdoor spaces QUIET HOURS between 10:00 pm-5:00 am pool/hot tub close 10:00pm

Top guest favorite

A swimming pool surrounded by a white wall features a pebble tech finish. Two lounge chairs are positioned on the edge of the pool, with green grass along one side. Bright sunlight reflects off the water, creating a shimmering effect.

Guesthouse in Willow

4.97 out of 5 average rating, 121 reviews

Poolside Guesthouse with Private Patio in Midtown

Welcome to the Poolside Guesthouse! Everything has been designed with you in mind to help you enjoy your time in Phoenix! Furniture and fixtures have been selected for your comfort and to help maximize the space. The Poolside Guesthouse has fantastic outdoor spaces for you to enjoy our beautiful weather & offers one of the best central locations with easy access to the airport, shopping, arts district, museums, bars and restaurants. TPT License #21525000 City of Phoenix License #2023-4161

Guest favorite

The exterior of a charming studio guesthouse is visible, showcasing a brown brick facade and a well-kept entrance. A small pathway leads to the door, and palm trees can be seen in the background against a bright blue sky.

Guesthouse in Phoenix College

4.97 out of 5 average rating, 1,252 reviews

Private, Sparkling Clean Historic DTPHX Guesthouse

This charming studio guesthouse in the Campus Vista historic district is a fantastic find! Situated in a friendly neighborhood in the heart of Phoenix, this newly remodeled living space is cozy and practical, surpassing many of the similar properties in quality and character. A short ten-minute drive from the Sky Harbor Airport, and located within walking distance to two major bus lines and the light rail, the guests are sure to enjoy the easy access to all the popular downtown destinations.

Top guest favorite

A cozy bedroom featuring a spacious bed with a custom leather headboard. A large black and white mural of cacti adds character to the room. A modern pendant light hangs above, complementing the warm tones of the wooden bed frame and the textured beige bedding.

Guest suite in Encanto

4.99 out of 5 average rating, 347 reviews

Private, desert-chic casita in vibrant Midtown PHX

Welcome to Casita Amelia, a modern rustic retreat central to all the action Phoenix has to offer. Welcoming and cozy, this newly updated private guest suite has all the luxuries of a modern hotel suite while being quietly tucked away in a cute Midtown neighborhood. Walk to Melrose District. You're also just 5-10 mins by car to Uptown & Camelback Corridor, 10 mins to Downtown (Footprint Center, Chase Field, Arizona Financial), 15 mins to Sky Harbor Airport, and 20 mins to State Farm Stadium.

Guest favorite

The outdoor pool area features a clear blue pool with a gently sloped entry. A green float is positioned in the water. Surrounding the pool are various plants and a shaded patio area with a built-in grill, offering a relaxing space for outdoor activities.

Guesthouse in North Encanto

4.9 out of 5 average rating, 215 reviews

Private Casita w/ Pool* & BBQ in Historic Melrose

*PLEASE READ HOUSE RULES IN "OTHER THINGS TO NOTE" AREA BEFORE BOOKING* Under no circumstance can one book the Airbnb for another guest . This violates our house rules as well as Airbnb policy. Read more under HOUSE RULES for more details. Our cozy casita is located in the Woodlawn Park neighborhood, a short car ride from the Melrose and Willo Districts. Located near some of the best restaurants in Phoenix, this is the perfect stay for visitors who want to explore the local food scene.

Top guest favorite

The open and inviting space features a comfortable queen-sized bed adorned with a colorful blanket. Above the bed, a mounted TV is positioned, while a staircase leads to the upper living area. Natural light filters in through a window, casting a relaxing ambiance.

Guest suite in Story

4.98 out of 5 average rating, 650 reviews

Studio 13 in heart of Downtown Phoenix !

Studio 13 is a modern, cozy, private space nestled in one of Phoenix’s beautiful historic districts, close to freeways, downtown restaurants and museums. You can walk or bike to restaurants. Studio 13 is closed off from the main house where i live for privacy, with a private entrance in the rear. There is a beautiful yard with a relaxing hot tub to enjoy. There are two Airbnb’s at this property outdoor areas are shared. AZ TPT Lic#21539063, STR-2023-001824

Top guest favorite

A spacious living area contains a light grey loveseat and a small wooden desk paired with a chair. A decorative lamp provides soft lighting beside the couch. Artwork is displayed on the wall above the desk, and large windows allow natural light to fill the room.

Guesthouse in Willow

5 out of 5 average rating, 214 reviews

Adorable Willo Cottage in Historic Central Phoenix

Peaceful one bedroom cottage in unbeatable location within Central Phoenix. Walking/ biking distance from light rail, restaurants, Heard Museum and Phoenix Art Museum. Enclosed backyard with a shared washer/dryer on property. The cottage has a queen bed, mini kitchen and private patio. Property is cleaned and sanitized according to the Airbnb cleaning procedures. 15 minutes from Sky Harbor Airport. 5 minutes from Encanto Park (Golf Course)

Superhost

An outdoor patio area is visible, featuring a large umbrella providing shade. A comfortable seating arrangement includes a sofa adorned with colorful pillows. Potted plants add greenery, while natural stone flooring enhances the inviting space, surrounded by soft drapes that frame the area.

Home in Encanto

4.89 out of 5 average rating, 253 reviews

Entire Private apartment, historic downtown

Your Private Retreat in Historic Downtown Phoenix Welcome to a private one-bedroom apartment—a peaceful, fully self-contained space with a separate entrance and a private patio. Nestled in the historic district of downtown Phoenix, this cozy getaway offers a quiet, quaint, and friendly atmosphere, perfect for relaxing after exploring the city. https://airbnb.com/rooms/1091526274311397985?source_impression_id=p3_1711840500_ibQfEDNzHJanWqtP

Superhost

A living room features a gray sofa flanked by two light-hued armchairs. A round coffee table sits centrally on a textured area rug, accompanied by two woven poufs. Green plants add a touch of nature, while sheer curtains allow daylight to filter through.

Home in Encanto

4.86 out of 5 average rating, 125 reviews

Family Friendly Home by Downtown with 3 Beds

Enter this beautifully remodeled 1946 home in the heart of Phoenix tucked away in the family-friendly Encanto Village community. Bright, spacious, airy and decorated to every detail for a proper vacation or for the perfect photo-op. Enjoy yourself with some fresh air as you are enjoying a drink in the front patio. Have a nice picnic or play in the grass in the backyard. Anywhere you want to go is within a short range.

Guest favorite

An open-concept guest house features modern furnishings and a spacious layout. A cozy seating area includes a brown leather sofa and metallic side tables, while a well-equipped kitchen with stainless steel appliances is visible in the background. Natural light filters through large windows.

Guesthouse in Willow

4.92 out of 5 average rating, 188 reviews

The Cambridge Cottage - Willo Historic District

Beautifully remodeled full guest house in Midtown Phoenix within the Willo Historic District designed with you in mind. Amazing location within walking distance of great restaurants, boutique shopping, coffee shops, light rail, and the Phoenix Arts District. Less than 15 minutes from Sky Harbor Airport and centrally located to everything in the valley you'll enjoy a charming neighborhood within the heart of all.

Guest favorite

A spacious studio suite features a king-sized bed with a tufted headboard and coordinating nightstands. A cozy seating area includes a modern gray sofa adorned with decorative cushions. A coffee table with magazines complements the inviting and well-lit space.

Guesthouse in Phoenix

4.97 out of 5 average rating, 615 reviews

Uptown Studio Great Neighborhood and Outdoor Space

Experience the charm of Uptown Phoenix in this peaceful garden studio, nestled in the historic district. This spacious retreat features a resort-style outdoor space, a cozy fire pit, and a sheltered dining area for relaxing evenings. Inside, unwind in a charming king-sized bed and a sparkling bathroom. Explore Uptown Phoenix, just minutes away, with vibrant restaurants, local shops, and exciting nightlife.