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Vacation rentals in Muscatine County

Find and book unique accommodations on Airbnb

Top-rated vacation rentals in Muscatine County

Guests agree: these stays are highly rated for location, cleanliness, and more.

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Guest favorite
The exterior of a two-story home features brick accents and a welcoming porch. A staircase leads to the entrance, flanked by a neatly maintained lawn. The surrounding area includes a fence for added privacy.
Home in Muscatine
4.91 out of 5 average rating, 75 reviews

La Casita Guest House

La Casita is a family freindly, fully remodeled 3 bedroom/2 bath home. We are located within a 3 minute drive to historical downtown Muscatine. The kitchen is fully equiped and the home features a king bed, a queen bed and a twin bed for use (a pack-n-play is available if requested). Other features include full tub/shower combos in each bathroom, full size washer & dryer, smoke/carbon monoxide detectors, self check in with keyless entry, wifi, smart TV, and an enclosed private backyard area.

Guest favorite
A historic four-bedroom home is captured with tall trees framing the exterior, set against a clear blue sky. The architectural features include a prominent turret and multiple windows, reflecting the home's charm. A snow-dusted yard leads to a view of the nearby Mississippi River.
Home in Muscatine
4.97 out of 5 average rating, 132 reviews

Historic West Hill Retreat

Beautiful historic 4 bedroom, 4 bath home within walking distance to shopping, bars/restaurants and all that downtown Muscatine has to offer. Enjoy sweeping views of the Mississippi River from several vantage points in and outside this home. The 3000 sf interior offers many places to gather and relax. Two of the bedrooms have on suite full baths. The other two bedrooms share a full bath. Additional amenities include, fully equipped kitchen, laundry, games, grill, outdoor entertainment area.

Top guest favorite
A bright eat-in kitchen features a wooden dining table surrounded by chairs, illuminated by pendant lights. A cozy bench sits near the entrance, while light streams through the window blinds. Wooden cabinetry and a granite countertop add functional elegance to the space.
Home in Muscatine
4.97 out of 5 average rating, 31 reviews

Helen's Henhouse

Welcome to the coziness of Helen's Henhouse, a lovingly restored 1890 home. Offering 4 cozy bedrooms, a delightful eat-in kitchen, an extra third-floor twin suite, and a generous living room featuring a dedicated work area, it's designed for retreats but perfect for any escape. Unleash your creativity in our well-equipped workspace, complete with 10 tables, design walls, a cutting station, and an ironing board. Your retreat, your way! A Retreat Haven for Every Stay. Unwind, Create, or Relax.

Top guest favorite
The log home features a front porch with several chairs, inviting relaxation while enjoying the surrounding nature. A wooden balcony extends from the upper level, complemented by decorative planters filled with flowers, enhancing the welcoming exterior.
Home in Letts
4.93 out of 5 average rating, 30 reviews

Shade Tree Farms in Letts, Iowa

Forget your worries in this spacious log home on 30 acres. Perfect for relaxing and renewing. Short drive to Muscatine with many historic sites, shops, unique restaurants. Near Grandview, Wapello, Letts, Columbus Junction with small town features and 35 miles from Iowa City. Mowed walking path around field. Exercise equipment. 2 car garage, 1 motorcycle garage. New pond. Privacy tucked into the field but just off the main highway. Sit and relax on massive front porch and watch the wildlife

Loft in Muscatine
New place to stay

Downtown;Walk to Shops, Restaurants, Entertainment

Located in the heart of Downtown - Enjoy great views of historic downtown Muscatine. - Steps away from restaurants, pubs, museums, and shopping. - Two blocks away from Mississippi Riverfront. - Enjoy a walk or bike ride along the trail system. - 2 bedrooms - one King and one Queen bed - WiFi, Smart TV and charging stations - Secure, safe location There are stairs to climb to reach the loft, and there is no elevator, but the spectacular views of Downtown are worth it when you get there!

Guest favorite
The exterior of a charming farmhouse is presented, featuring a white facade with a sloped roof. Lush green grass surrounds the front porch, which is shaded by large trees. A welcoming atmosphere is suggested by the open door and inviting entryway.
Home in Muscatine
4.97 out of 5 average rating, 110 reviews

Michelle's Place- The Farm House

Welcome to Michelle's Place- The Farm House. Where it's a farm feel, centrally located in town. It's a completely remodeled home with intentional planning and beautiful design for you to come rest at a home away from home. Close to parks, and walking trials while also only 4 minutes away from the historic downtown area! All aspects inside the home were uniquely picked by the host. With seasonal farm fresh varieties of berries, fruits, and vegetables to be enjoyed in your backyard!

Home in Muscatine
New place to stay

Bridgeview home in Muscatine, Ia.

Relax with the whole family at this peaceful place to stay. A beautiful home that sits right on the edge of the Mississippi River along the train tracks in downtown Muscatine, right next to the bridge. Breathtaking views and house is right on the bike trail and is walking distance from the best restaurants and bars in town. Also has a big hot tub on the deck where you can relax with family and friends and enjoy the beautiful views overlooking the Mississippi River and bridge.😎

Guest favorite
A view of the open-concept space highlights a kitchen area with a green countertop and a stove. The living area features light brown and tan upholstery on the seating, complemented by green carpet. A ceiling fan is visible along with warm lighting throughout the space.
Loft in Muscatine
4.94 out of 5 average rating, 236 reviews

The Emerald Loft Apartment

Stay in a Historic District Downtown loft! River views. Nearby park, playground, bike trails, boat ramps & marina. Shopping, live music, & restaurants. Private entry with 1,000 sqr ft of space, open concept, full kitchen, TV, laundry, private bath, literally right in middle of everything. Check in at Creations by Oz "Jewelry, Wine, & Unique Finds". Enjoy a glass of wine upon check-in. Come hungry. Photo comments provide dining options within steps of the Emerald Room.

Guest favorite
A balcony offers a view of the Mississippi River, featuring flower boxes with colorful blooms along the railing. Two chairs are positioned for relaxation, overlooking a landscaped area and nearby road, with additional greenery visible along the riverbank.
Apartment in Muscatine
5 out of 5 average rating, 30 reviews

Beautiful Condo Downtown with River Views

3rd Floor Condo in the old Hotel Muscatine 100 plus years old just totally refurbished condo with a Beautiful Balcony with view of bridge and Mississippi River 2 bedrooms 1 full bed bedroom and 1 queen bed bedroom with both views of river and bridge and a 1/2 bath bath and full bath with soaking tub and rain shower, stackable washer and dryer, full kitchen fully stocked, desk area, beautiful patio with chairs over looking lit up bridge and river Adults Only 2 Night Minimum

Apartment in Muscatine
New place to stay

Alexander G. Clark Suite

This large efficiency apartment offers a comfortable living space, fully furnished and recently refurbished with fresh paint throughout. It includes a separate downstairs entry room, providing added privacy and convenience. The kitchen is enhanced by a charming bay window, creating a bright and inviting atmosphere. Perfect for those seeking a stylish and functional living space! Included are utilities, Internet,Take it easy at this unique and tranquil getaway.

Guest favorite
A serene country house is reflected in the still water of a private pond. Lush green grass and trees surround the property, with a gentle gradient of sky transitioning from soft blue to warmer tones. The structure features a porch and numerous windows.
Farm stay in Muscatine
4.82 out of 5 average rating, 11 reviews

Captain's Cove Muscatine

A relaxing country getaway for all of life's moments! Rental includes a fully furnished house, kitchen, washer & dryer, WiFi, gas grill (1 propane tank), access to 4 private ponds (no fishing license required), 3 kayaks, adult/youth/infant lifejackets, concrete patio w/ firepit and outdoor patio furniture, and 5+ acres of private country land access (surrounded by 40 acres of private farmland). If you have any suggestions/ideas please let us know!

Superhost
A spacious room features a queen bed adorned with a nature-themed quilt. A seating area includes a striped sofa. A ladder leads to a loft space, and a set of bunk beds is positioned to the side. Natural light filters in through multiple windows.
Place to stay in Letts
4.75 out of 5 average rating, 12 reviews

Loft Cabin #1 sleeps up to 8

Open floor plan, bunk bed set, queen bed, sofa bed, & full size loft bed, includes a kitchenette complete with mini fridge, microwave, skillet, dual coffee maker & toaster. Furnished with dish set, some utensils, k-cups, towels & linens except blankets. Outdoor picnic table, fire pit, grill, and covered porch, complete with rocking chairs and a reclaimed church pew to enjoy a quiet evening sunset or a peaceful morning sunrise.

Popular amenities for Muscatine County vacation rentals

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