House vacation rentals in Lewis and Clark Lake

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Top-rated house rentals in Lewis and Clark Lake

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Top guest favorite
The modern kitchen features sleek cabinetry and a spacious quartz island with seating for six. Stainless steel appliances are included, alongside a mounted television. Pendant lighting hangs above the island, providing ample illumination in the open area.
Home in Vermillion
4.96 out of 5 average rating, 105 reviews

The Vista Villa

Welcome to The Vista Villa, Vermillion's premier short term accommodations! Whether gathering with friends for a collegiate event or hosting a family holiday, this home is sure to accommodate inside & out. The full kitchen dawns an oversized quartz island with seating for 6. The backyard features a deck with privacy wall ideal for grillin’ & chillin’. There is off and on-street parking available as well as a 2-stall garage. All three bedrooms host their own bathroom. The primary suite features a walk-in tiled shower with rain shower head, king sized bed, double closets, and patio door access to the deck. All bedroom closets include organizers, suitable for extended stays! There is also a half bath for extra guests to utilize.

Top guest favorite
The basement space features a large artificial grass area with a cornhole setup. A mural displaying the name 'Rose Street Retreat' is painted on a textured gray wall, complemented by a decorative rose and leaf design.
Home in Sioux Falls
5 out of 5 average rating, 108 reviews

Rose Street Retreat

THIS is what you are looking for in an airbnb! Simple. Clean. Fun. At the Rose Street Retreat you will enjoy a fully remodeled home located in the best part of Sioux Falls. The home is immediately adjacent to Tomar Park soccer fields, tennis courts, and the bike trails (one of the most underrated assets to Sioux Falls). The home has a real bed for each guest so everyone can wake up rested and ready for fun. From hot tub and fire table to foosball, this rental has something for everyone!

Guest favorite
A cozy sitting area features a blue accent chair and a patterned area rug. Natural light filters through the bay windows, illuminating the space. A small lamp stands next to the chair, and a dark coffee table is positioned in the center, enhancing the inviting atmosphere.
Home in Mitchell
4.8 out of 5 average rating, 392 reviews

My little green Granny house - near Corn Palace

This cozy house has so much to offer with sleeping for 4 to 8 and could accommodate more with the pack-and-play. King bed sleeps two, full size bed, and two full size sleeper sofas each sleep one or two people. Extra blankets and pillows in rooms. Close to shopping, banks, eating establishments and the community theater. Parking off street or behind the house with both front and back door entrance. Grill, fire pit and swing set out back. No smoking. No parties. Great place to relax and enjoy.

Top guest favorite
The split-level home is set against a backdrop of greenery, featuring a stone chimney and an American flag. An attached garage is visible alongside the well-maintained gravel driveway. Nearby, a large barn adds to the rural landscape, creating a calm and serene environment.
Home in Wakonda
4.98 out of 5 average rating, 215 reviews

Quiet split level farm home w/ garage parking

Welcome to the Gregoire Farm. Our home is a recently remodeled split level located on our family farm. It has 3 bedrooms and two baths as well a sofa bed. Park your car in our two car garage. Great place for a larger group to have plenty of room. A little ways off the beaten path but worth a little extra drive. 15 min drive to Vermillion, 20 min drive to Yankton and 35 minutes to Sioux Falls. If you are looking for a quiet place to yourself please consider us. Non-smoking, pet free home.

Top guest favorite
A spacious hot tub is positioned on a patio, surrounded by a privacy fence. Two copper mugs are placed on a wooden tray, with two plush blue towels neatly arranged beside the steps leading into the tub, inviting guests for a relaxing soak.
Home in Sioux Falls
4.96 out of 5 average rating, 117 reviews

Couples Escape: Hot Tub & Walk to Brewery + eBikes

Enjoy a romantic getaway in this home within a short distance to two Breweries, bakery & coffee shops! Dine In: we provide coffee, eggs, butter, cinnamon rolls, spices, etc. in our stocked kitchen. Relax in your private hot tub, cuddle up for movies on the streaming apps, play guitar, enjoy a fire on your patio, or take a short 12 min drive downtown! Golf at nearby Prairie Green! 2 min away! Age 24 years & up only. 2 guests max. Inquire for other dates as we may open the calendar!

Top guest favorite
A lower level entertainment room features a gray sofa adorned with a red blanket and a decorative pillow showcasing the initials 'USD.' A ping pong table and a foosball table are visible, with a university flag displayed on the wall.
Home in Vermillion
4.99 out of 5 average rating, 124 reviews

Townhouse in Vermillion close to USD

Relax with all your family & friends as you enjoy the wonderful town of Vermillion during your stay in this comfortable and spacious duplex. Conveniently located close to USD's campus, restaurants, and shopping. Walk down and enjoy a USD event. Or take the family to the park. Closely located to Prentis Park where you can cool off at pool, play on the playground or basketball courts and enjoy the beautiful picnicking areas. This home is sure to accommodate for a fun stay during your visit.

Top guest favorite
A private hot tub is surrounded by charming outdoor seating, with a ceiling fan above for comfort. Soft lighting illuminates the space, enhancing its inviting atmosphere. The entrance to an exterior patio is visible, providing easy access to the outdoors.
Home in Sioux Falls
4.97 out of 5 average rating, 414 reviews

Inspiration Ranch-HOT TUB/lower unit/SUPER CLEAN!!

PLEASE READ!! Welcome to Inspiration Ranch, located in a safe, new neighborhood with quick access to restaurants, shopping, and stores. This private lower unit has its own entrance via the garage stairs. Enjoy full access to the entire space featuring tall ceilings, large windows, and an open, inviting layout. You’ll feel right at home the moment you arrive—perfect for relaxing or exploring the area! Guests are always happy and comfortable here! ✨ PLEASE READ MY REVIEWS!

Top guest favorite
A well-appointed bedroom features a spacious bed with a padded headboard, flanked by two bedside tables with lamps. A decorative bench sits at the foot of the bed, and a soft area rug covers the floor. The walls are painted in a calming gray hue.
Home in Sioux Falls
4.95 out of 5 average rating, 322 reviews

The Cozy Place

Welcome to our Cozy Place, close to everything in Sioux Falls. When you step into this basement apartment style unit, you can’t help but appreciate the fresh and updated look with a warm and inviting feel. This house is built as a triplex therefore is separated into 3 apartments that operate as Airbnb stays. This listing is for the newly remodeled basement unit / apartment, and you will have your privacy and enjoy the comforts it provides.

Top guest favorite
The exterior of a two-story cottage features a combination of white and red-brown shingles. A covered porch with wooden columns is visible, along with large windows that allow light into the interior. A well-maintained pathway leads to the entrance, bordered by decorative stone.
Home in Wayne
4.95 out of 5 average rating, 201 reviews

D'Brick House in Wayne

D'Brick Cottage is located across from Wayne State College in Wayne, NE. This recently renovated 2-bedroom house offers a comfortable place to get away. Includes indoor fireplace, equipped kitchen with all appliances and conveniences, plus laundry in the basement. The perfect place to get some rest for traveling employees, visiting family, or just because. SPECIAL NOTE: The basement contains an apartment that is rented separately.

Top guest favorite
The house is set in a lush green landscape, showcasing vibrant grass and surrounding trees. The exterior features a warm red hue, and multiple large windows invite natural light. The peaceful rural environment is emphasized by the spacious yard, creating a sense of tranquility.
Home in Lake Andes
4.92 out of 5 average rating, 122 reviews

Francis Case Reservoir Home

The house is in a rural setting just west of Lake Andes, S.D. The town has a grocery store, gas stations and a BBQ place . It is also located close to Fort Randall/Francis Case Reservoir, six miles north of the dam with great access to boat ramps. The house has YouTube TV with a fishing theme throughout the house. There are a few steps to get up to the main bathroom and the 3 bedrooms and a few steps down to the recreation room.

Superhost
A distinctive A-frame house is set against a clear blue sky. Large glass panels create an open feel, surrounded by well-maintained landscaping featuring lush grasses, ornamental plants, and a mix of trees, offering a peaceful retreat in a natural environment.
Home in Canton
4.83 out of 5 average rating, 224 reviews

Relaxing Riverview Cabin with Scenic Hot Tub

Relaxing Riverview House with stunning view and HOT TUB. Take advantage of our great location and quiet setting nestled in the trees along the Sioux River. Small town services are only 10 minutes away and city shopping and entertainment is less than 20 minutes. You will have access to the Sioux River for canoeing, kayaking, fishing or just hiking by the river. (Please provide your own outdoor recreation equipment)

Top guest favorite
A spacious living area is presented with soft beige walls and large windows allowing natural light. A modern coffee table is centered on a plush area rug, while a piano stands in one corner. Comfortable seating includes upholstered chairs and a cozy sofa.
Home in Mitchell
4.98 out of 5 average rating, 102 reviews

Spacious modern, cozy now offering 5 bedroom home.

Welcome to your home away from home! This is a perfect place for a business traveler, family on the road or simply those visiting our beautiful city. Our spacious cheerful home sits on a culdesac, offering a quiet and relaxing environments with breathtaking backyards views to include the winter months and gorgeous summer sunsets.Come and experience the beauty South Dakota offers. 24 hrs self check-In Available.

Popular amenities for Lewis and Clark Lake house rentals